Rheological studies of PLLA–PEO–PLLA triblock copolymer hydrogels

Aamer, Khaled A.; Sardinha, Heidi; Bhatia, Surita R.; Tew, Gregory N.

doi:10.1016/s0142-9612(03)00632-x

Cited by 124 publications

(117 citation statements)

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“…Several block copolymers consisting of polyethylene glycol (PEG) and biodegradable polyesters, such as poly-L-lactic acid (PLLA), polyglycolic acid (PGA) (or their PLGA copolyesters), and the pluronic series, have been prepared as synthetic biomaterials and examined as candidate in situ-forming gel systems [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

A biodegradable, injectable, gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window

et al. 2010

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Section: Introductionmentioning

confidence: 99%

A biodegradable, injectable, gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window

et al. 2010

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“…When preparing the formulation, the vehicle should have certain mechanical strength as many native tissues have moduli in the kPa range (Carter et al, 2001;Aamer et al, 2004). Otherwise, the gelling agent is likely to diffuse out of the depot and into the surrounding tissue since the fluid flow in subcutaneous tissue usually ranges from 7 to 53 mL/100 g per minute (Schoenhammer et al, 2009;Supper et al, 2014).…”

Section: Rheological Measurementmentioning

confidence: 99%

Self-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation

Cao

et al. 2016

Drug Delivery

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(2016) Self-assembled drug delivery system based on low-molecular-weight bisamide organogelator: synthesis, properties and invivo evaluation, Drug Delivery, 23:8, 3168-3178, DOI: 10.3109/10717544.2016 RESEARCH ARTICLESelf-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation Zhen Li, Jinxu Cao, Heran Li, Hongzhuo Liu, Fei Han, Zhenyun Liu, Chao Tong, and Sanming Li School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China Abstract Context: Orgnaogels based on amino acid derivatives have been widely used in the area of drug delivery. Objective: An organogel system based on L-lysine derivatives was designed and prepared to induce a thermal sensitive implant with higher transition temperature, better mechanical strength, and shorter gelation time. Materials and methods: The organogel was prepared by injectable soybean oil and methyl (S)-2,5-ditetradecanamidopentanoate (MDP), which was synthesized for the first time. Candesartan cilexetil (CC) was chosen as model drug. Different formulations were designed and optimized by response surface method. Thermal, rheology properties, and gelation kinetics of the optimized formulation had been characterized. The release behaviors in vitro, as well as in vivo were evaluated in comparison with the oily solution of drugs. Finally, the local inflammation response of in situ organogel was assessed by histological analysis. Results and discussion: Results showed that the synthesized gelator, MDP, had a good gelation ability and the organogels obtained via the self-assembly of gelators in vegetable oils exhibited great thermal and rheology properties, which guaranteed their state in body. In vivo pharmacokinetic demonstrated that the organogel formulation could extend the drug release and maintain a therapeutically effective plasma concentration at least 10 d. In addition, this implant showed acceptable moderate inflammation. Conclusion: The in situ forming L-lysine-derivative-based organogel could be a promising matrix for sustained drug delivery of the drugs with low solubility. KeywordsBiocompatibility, gelator, in situ implant system, in vivo release, organogel History

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“…5,6 Generally the morphology of a ternary polymer blend is depended on interaction parameters among three components, rheological properties of the components and processing conditions. 7,8 From a thermodynamic viewpoint, ternary blends of homo polymers A, B, and C can typically display four types of morphologies, as predicted by the minimizing of the interfacial free energy. Three of them are complete wetting types of morphology, where one of the polymers forms a layer at the interface of the two others that can be seen in Figure 1(a) to (c).…”

Section: Introductionmentioning

confidence: 99%

Morphology Evolution of Poly(L-lactic acid) (PLLA), Poly(ε-caprolactone) (PCL) and Polyethylene Oxide (PEO) Ternary Blend and Their Effects on Mechanical Properties for Bio Scaffold Applications

Ezzati¹,

Ghasemi²,

Karrabi³

et al. 2014

Polymer Korea

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Ternary blends of poly(L-lactic acid) (PLLA), poly(ε-caprolactone) (PCL) and polyethylene oxide (PEO) were produced with different concentrations of components via melt blending. By leaching the PEO from the samples by water, porous materials were obtained with potential application for bio scaffolds. Sample porosity was evaluated by calculating the ratio of porous scaffold density (ρ*) to the non-porous material density (ρ s ). Highest porosity (51.42%) was related to the samples containing 50 wt%. of PEO. Scanning electron microscopy (SEM) studies showed the best porosity resulted by decreasing PLLA/PCL ratio at constant concentration of PEO. Crystallization behavior of the ternary blend samples was studied using differential scanning calorimetry (DSC). Results revealed that the crystallinity of PLLA was improved by addition of PEO and PCL to the samples. The porosity plays a key role in governing the compression properties. Mechanical properties are presented by Gibson-Ashby model.

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Rheological studies of PLLA–PEO–PLLA triblock copolymer hydrogels

Cited by 124 publications

References 50 publications

A biodegradable, injectable, gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window

A biodegradable, injectable, gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window

Self-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation

Morphology Evolution of Poly(L-lactic acid) (PLLA), Poly(ε-caprolactone) (PCL) and Polyethylene Oxide (PEO) Ternary Blend and Their Effects on Mechanical Properties for Bio Scaffold Applications

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