Rheological Study of Selected Pharmaceutical Semisolids

Boylan, James C.

doi:10.1002/jps.2600550708

Cited by 34 publications

(10 citation statements)

References 6 publications

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“…The maximum shear rate was in the region of 1,700 sec.-1, a value close to that which has often been used before for pharmaceutical systems (6)(7)(8)(9). The upper temperature in each case was limited by the materials becoming nonlinear in their viscoelastic properties.…”

Section: Resultssupporting

confidence: 67%

“…Continuous shear-rheology has been a popular approach (4,5 ) and in particular the Ferranti-Shirley viscometer, with automatic flow-curve recording unit, has been much utilized (6)(7)(8)(9)(10). Continuous shear-rheology has been a popular approach (4,5 ) and in particular the Ferranti-Shirley viscometer, with automatic flow-curve recording unit, has been much utilized (6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

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Viscoelastic Properties of Pharmaceutical Semisolids I: Ointment Bases

Davis

1969

Journal of Pharmaceutical Sciences

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Section: Resultssupporting

confidence: 67%

mentioning

confidence: 99%

Viscoelastic Properties of Pharmaceutical Semisolids I: Ointment Bases

Davis

1969

Journal of Pharmaceutical Sciences

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“…Continuous shear viscometry was frequently employed in the study of semisolid creams and ointments (Mutimer et al, 1956;Boylan, 1966Boylan, , 1967Christov, 1967;Eros and Kedvessy, 1969;Tsagareishvili et al, 1969;Davis, 1969; . It has several disadvantages but only those which are relevant to petrolatum and similar materials will be discussed here.…”

Section: B Continuous Shear Viscometrymentioning

confidence: 99%

Structural, Rheological and Textural Properties of Soft Paraffins

Barry

Grace

1971

Journal of Texture Studies

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Various aspects of soft paraffins, with the main emphasis on their rheological properties, are considered in a review of 119 references. Rheological test methods currently used are critically appraised in sections on penetrometry, continuous shear viscometry, oscillatory testing and creep analysis. The chemical nature, microscopic structure, miscellaneous methods of standardisation, formulation and work softening of petrolatums are reviewed. The textural properties of soft paraffins are discussed; a master curve of the rheological conditions operative during spreading on the skin is presented.

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“…With a complete rheological characterization of petroleum jelly, it may be possible to make necessary adjustments during the manufacturing processes of ointments and creams as well as to achieve optimal product performances. Due to its paramount importance in pharmaceutical and cosmetic industries, many attempts have been made to investigate the rheological properties of petroleum jelly during the past several decades by means of a continuous shear viscometry, creep/creep recovery tests, and small amplitude oscillatory shear measurements (Boylan, 1966;Davis, 1969;Fu and Lidgate, 1985;Pena et al, 1994;Pandey and Ewing, 2008). However, only a little attention has been given to the rheological characterization in actual usage conditions such as spreading and rubbing onto the human body or skin, even though such a rheological information is much more essential from a view-point of consumer's demands (Lee et al, 2008;Cha et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Rheological evaluation of petroleum jelly as a base material in ointment and cream formulations: Steady shear flow behavior

Park

Song

2010

Arch. Pharm. Res.

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The objective of the present study is to systematically characterize a nonlinear rheological behavior of petroleum jelly (petrolatum) in steady shear flow fields correspondent to the spreading condition onto the human body. With this aim, using a strain-controlled rheometer, the steady shear flow properties of commercially available petroleum jelly have been measured at 37 degrees C (body temperature) over a wide range of shear rates. In this article, the shear rate dependence of steady shear flow behavior was reported from the experimentally obtained data. In particular, the existence of a yield stress and a non-Newtonian flow behavior were discussed in depth with a special emphasis on their importance in actual application onto the human body. In addition, several inelastic-viscoplastic flow models including a yield stress parameter were employed to make a quantitative description of the steady shear flow behavior, and then the applicability of these models was examined in detail. Main findings obtained from this study can be summarized as follows: (1) Petroleum jelly exhibits a finite magnitude of yield stress. The appearance of a yield stress is attributed to its three-dimensional network structure that can show a resistance to flow and plays an important role in determining a storage stability and sensory feature of the product. (2) Petroleum jelly demonstrates a pronounced non-Newtonian shear-thinning flow behavior which is well described by a power-law equation and may be interpreted by the disruption of a crystalline network under the influence of mechanical shear deformation. This rheological feature enhances sensory qualities of pharmaceutical and cosmetic products in which petroleum jelly is used as a base material during their actual usage. (3) The Casson, Mizrahi-Berk, Heinz-Casson and Herschel-Bulkley models are all applicable and have almost an equivalent ability to quantitatively describe the steady shear flow behavior of petroleum jelly whereas the Bingham model does not give a good validity. Among these flow models, the Herschel-Bulkley model provides the best applicability.

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Rheological Study of Selected Pharmaceutical Semisolids

Cited by 34 publications

References 6 publications

Viscoelastic Properties of Pharmaceutical Semisolids I: Ointment Bases

Viscoelastic Properties of Pharmaceutical Semisolids I: Ointment Bases

Structural, Rheological and Textural Properties of Soft Paraffins

Rheological evaluation of petroleum jelly as a base material in ointment and cream formulations: Steady shear flow behavior

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