Rheumatic disease in elderly population, how different from the conventional presentations?

Dhaon, Pooja; Tripathy, Saumya Ranjan

doi:10.15305/ijrci/v3is1/174

Cited by 4 publications

(2 citation statements)

References 61 publications

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“…Overall, rheumatic diseases of late-onset exhibit different clinical and immunological profiles compared to those of early-onset, which can lead to underdiagnosis of the disease. Even though the disease sometimes appears to have a mild clinical presentation, complications and prognosis can be bad due to co-morbidities in the old age [26]. It is necessary to carefully assess elderly patients presenting with rheumatic symptoms so that the disease does not go underdiagnosed or missed.…”

Section: The Pattern Of Rheumatological Diseasesmentioning

confidence: 99%

Geriatric Rheumatology: The Need for a Separate Subspecialty in the Near Future

Poudel¹,

Yu²

2020

Cureus

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Rheumatology is a broad specialty in itself, and it involves caring for patients of all age groups. Patients of different age groups have different characteristics and a one-size-fits-all approach is not feasible in catering to their diverse medical needs. The presentation and the manifestations of diseases vary in different age groups. We have pediatric rheumatology as a separate subspecialty where pediatric patients with rheumatological diseases are provided specific care best suited to their needs. However, for older patients, such a separate subspecialty is not widely available in medical practice. Geriatric rheumatology or gerontorheumatology is a branch of rheumatology dealing with older patients with rheumatological diseases. It is high time to consider establishing geriatric rheumatology as a separate subspecialty to provide better care for older patients.

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Section: The Pattern Of Rheumatological Diseasesmentioning

confidence: 99%

Geriatric Rheumatology: The Need for a Separate Subspecialty in the Near Future

Poudel¹,

Yu²

2020

Cureus

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“…Pasien dengan usia onset lebih tua cenderung memiliki tampilan klinis yang lebih ringan dan lebih mudah mencapai remisi sehingga menunjukkan proporsi remisi yang lebih tinggi dibanding usia onset yang lebih muda. 11 Huscher menemukan pasien dengan usia onset yang lebih muda memiliki aktivitas penyakit yang lebih buruk dan jarang mengalami remisi.…”

Section: Analisis Statistikunclassified

Hubungan Antara Parameter Klinis Dan Laboratoris Dengan Status Remisi Penyakit Pada Pasien Artritis Reumatoid Yang Mendapat Terapi Metotreksat

Suryana

Sari

Tamayanti

et al. 2019

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Artritis reumatoid (AR) adalah penyakit autoimun yang etiologinya belum diketahui. Metotreksat adalah DMARD (disease-modifying antirheumatic drug) yang paling sering digunakan pada AR, namun respons terhadap metotreksat bervariasi di antara populasi. Data mengenai faktor klinis dan laboratoris yang berhubungan dengan remisi pada AR yang diterapi dengan metotreksat masih tidak konsisten. Penelitian ini bertujuan untuk mengetahui faktor-faktor klinis dan laboratoris yang berhubungan dengan remisi pada pasien AR yang mendapat terapi metotreksat. Data diperoleh dari pasien AR yang memenuhi kriteria ACR-EULAR 2010 dengan desain penelitian observasional dan pendekatan potong lintang. Data meliputi jenis kelamin, usia onset penyakit, durasi penyakit, indeks masa tubuh (IMT), tender joint count (TJC), swollen joint count (SJC), visual analog scale (VAS) nyeri, disease activity score (DAS)-28 awal, laju endap darah (LED), anti-cyclic citrullinated protein (CCP), dan rheumatoid factor (RF). Variabel dianalisis secara statistik dengan uji chi square dilanjutkan regresi logistik multipel. Penelitian ini melibatkan 88 pasien AR, terdiri dari 85,2% wanita (n = 75) dan 14,8% pria (n = 13), rerata usia 54,78±11,34. Proporsi remisi pasien adalah 26,1%. Dari analisis bivariat dengan uji chi square didapatkan variabel yang berhubungan bermakna terhadap remisi, yaitu usia onset (p = 0,037), VAS nyeri (p = 0,030) dan LED (p = 0,038). Dapat disimpulkan bahwa usia onset, VAS nyeri, dan LED berhubungan bermakna dengan remisi penyakit pasien AR yang diterapi dengan metotreksat.

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The impact of tocilizumab on anxiety and depression in patients with rheumatoid arthritis

Tiosano

Yavne

Watad

et al. 2020

Eur J Clin Investigation

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BackgroundMood disorders, such as anxiety and depression, are extremely prevalent among patients with rheumatoid arthritis (RA). In this study, we assessed the impact of treatment with tocilizumab (TCZ), an IL‐6 antagonist, upon anxiety and depressive symptoms in a cohort of RA patients.Materials and MethodsStudy participants were adults diagnosed with RA who received a weekly subcutaneous injection of tocilizumab for 24 weeks. We used the Hamilton Depression (HDRS) and Anxiety (HAMA) scores in order to assess the severity of depression and anxiety, respectively. RA disease activity indices and depression and anxiety levels were assessed at baseline, 4 weeks and study completion.ResultsUltimately, 91 patients were included in the study. The mean age was 54 years, and the majority were female (79%). The mean score in all disease activity indices as well as depression and anxiety levels decreased dramatically from baseline to study completion. Sixty patients (66%) demonstrated a significant decrease in anxiety and/or depression levels. When logistic regression was performed, an HDRS score indicative of depression at study baseline demonstrated an independent association with a significant psychiatric response whilst older age and increased baseline weight were negatively associated. HAMA and HDRA scores correlated with the following RA disease activity parameters, respectively; HAQ‐DI (r = .4, .42), DAS28 (r = .29, .32) and CDAI (0.28 and 0.33), all of them were statistically significant (P < .01).ConclusionsThis study has demonstrated a favourable impact of TCZ therapy on parameters reflecting depression and anxiety severity in patients with RA.

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Rheumatic disease in elderly population, how different from the conventional presentations?

Cited by 4 publications

References 61 publications

Geriatric Rheumatology: The Need for a Separate Subspecialty in the Near Future

Geriatric Rheumatology: The Need for a Separate Subspecialty in the Near Future

Hubungan Antara Parameter Klinis Dan Laboratoris Dengan Status Remisi Penyakit Pada Pasien Artritis Reumatoid Yang Mendapat Terapi Metotreksat

The impact of tocilizumab on anxiety and depression in patients with rheumatoid arthritis

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