Rheumatoid arthritis affects left ventricular mass: Systematic review and meta-analysis

Corrao, Salvatore; Argano, Christiano; Pistone, Giovanni; Messina, Silvia; Calvo, Luigi; Perticone, Francesco

doi:10.1016/j.ejim.2015.02.008

Cited by 24 publications

(20 citation statements)

References 38 publications

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“…In both studies, RA patients were compared with healthy subjects, and none of the patients or control subjects had any associated comorbidities to verify the effect of the disease on the heart. Three successive systematic reviews with meta-analyses corroborated the above-described findings (4)(5)(6). The first meta-analysis used pooled data from 10 controlled studies and confirmed valvular and pericardial involvement in RA (4), the second confirmed the increased prevalence of left ventricular diastolic dysfunction in patients with RA (5), and the third highlighted the detrimental effect of RA on left ventricular mass (6).…”

supporting

confidence: 53%

Cardiovascular Events in Rheumatoid Arthritis—Time to See Beyond Articular Involvement in “Real World” Clinical Practice: Comment on the Article by Mackey et al

Corrao

Messina

Allotta

et al. 2016

Arthritis & Rheumatology

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supporting

confidence: 53%

Cardiovascular Events in Rheumatoid Arthritis—Time to See Beyond Articular Involvement in “Real World” Clinical Practice: Comment on the Article by Mackey et al

Corrao

Messina

Allotta

et al. 2016

Arthritis & Rheumatology

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“…A recent meta-analysis of pooled data from 16 studies suggested that RA characteristically correlates with increased absolute or indexed LV mass (32). In the present study, we report that both the patients with RA and the non-RA participants have declining LV mass index over 5 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Five-year changes in cardiac structure and function in patients with rheumatoid arthritis compared with the general population

Davis

Lin

et al. 2017

International Journal of Cardiology

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Background Patients with rheumatoid arthritis (RA) have increased risk of heart failure with preserved ejection fraction. The development and progression of left ventricular dysfunction before onset of clinical heart failure are unknown. The objective of this study was to evaluate longitudinal changes in cardiac structure and function of patients with RA compared with persons in the general population. Methods A prospective longitudinal study of a population-based cohort of 160 patients with RA and a population-based cohort of 1,391 persons without RA (non-RA cohort) was performed. Each participant underwent 2-dimensional, pulsed-wave tissue Doppler echocardiography at baseline and after 4 to 5 years of follow-up. Age- and sex-adjusted linear regression models were used to test for differences between the RA and non-RA cohorts in annualized rates of change for echocardiographic parameters. Results Mitral A velocity increased more rapidly among the patients with RA than the non-RA cohort (age- and sex-adjusted parameter estimate, 0.030; P<.001). Correspondingly, the mean mitral inflow E/A ratio decreased faster in the RA cohort than the non-RA cohort (adjusted parameter estimate, −0.096; P<.001). The left atrial volume index increased at a higher rate in the RA cohort than the non-RA cohort (adjusted parameter estimate, 0.150; P<.001). Conclusions This pattern of echocardiographic findings confirms previous cross-sectional studies and indicates that subclinical changes in diastolic function occur more rapidly over 5 years in RA patients than in the general population. Further research into the mechanisms of myocardial disease in these patients and the relationship with disease activity and treatment is warranted.

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“…Compared to normal subjects, patients with RA are less likely to have normal geometry even after adjusting for cardiovascular risk factors and comorbidities, with concentric (LV) remodelling being the most prevalent abnormality [28]. The effect of RA on LV mass remains unclear because of inconsistent findings from the studies [27,28]. Midtbo et al showed that increased disease activity is associated with greater LV relative wall thickness independent of confounders such as hypertension, age and female gender [29].…”

Section: Ventricular Remodellingmentioning

confidence: 96%

“…Increased absolute and indexed left ventricular (LV) mass in patients with RA has been reported to be associated with increased risks of CV morbidity and mortality [27]. Compared to normal subjects, patients with RA are less likely to have normal geometry even after adjusting for cardiovascular risk factors and comorbidities, with concentric (LV) remodelling being the most prevalent abnormality [28].…”

Section: Ventricular Remodellingmentioning

confidence: 99%

Echocardiography in the Assessment of Patients with Rheumatologic Diseases

Al-Mohaissen

Chan

2016

Curr Cardiol Rep

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Cardiovascular disease is an important extra-articular manifestation of rheumatologic diseases leading to considerable mortality and morbidity. Echocardiography emerges as a useful non-invasive technique for the screening and evaluation of cardiac involvement in these patients. With the technological advancement in echocardiographic techniques, we have gained a greater appreciation of the prevalence and nature of the cardiac involvement in these patients, as detection of subclinical disease is increasingly feasible. This review discusses cardiac involvement in patients with rheumatoid arthritis, systemic lupus erythematosus, anti-phospholipid antibody syndrome, systemic sclerosis and ankylosing spondylitis, and the role of different echocardiographic modalities in their evaluation.

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Rheumatoid arthritis affects left ventricular mass: Systematic review and meta-analysis

Cited by 24 publications

References 38 publications

Cardiovascular Events in Rheumatoid Arthritis—Time to See Beyond Articular Involvement in “Real World” Clinical Practice: Comment on the Article by Mackey et al

Cardiovascular Events in Rheumatoid Arthritis—Time to See Beyond Articular Involvement in “Real World” Clinical Practice: Comment on the Article by Mackey et al

Five-year changes in cardiac structure and function in patients with rheumatoid arthritis compared with the general population

Echocardiography in the Assessment of Patients with Rheumatologic Diseases

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