Rheumatoid arthritis and pigmented villonodular synovitis: comparative analysis of cell polyploidy, cell cycle phases and expression of macrophage and fibroblast markers in proliferating synovial cells

Abstract

In spite of their histologically homogeneous appearance, proliferating synovial cells display a heterogeneous immunophenotype in both RA and PVNS, indicating functional properties of both macrophages and fibroblasts. Aneuploidy seems to be a special feature of diffuse PVNS.

Application of pulsed-magnetic field enhances non-viral gene delivery in primary cells from different origins

“…The highest transfection rates were achieved in synoviocytes and were attributed to their macrophage-like characteristics [63][64][65]. Consistently, we previously showed that more than 80% of the synoviocytes took up superparamagnetic nanoparticles within 24 h [54].…”

Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches

“…Previous studies demonstrated that proliferating cells in PVNS are mainly composed of synovial cells with features of both macrophages and fibroblasts (43). A temporally limited proliferation of these cells can also be seen in the active phase of RA.…”

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

“…In RA and other arthritides, modest proliferation has been described, at least in some reports, in a range of cell types, including macrophages (24,29,30). In early human atheroma, the predominant proliferating cell type is the macrophage lineage foam cell (26) and, during an inflammatory response in the brain, microglial proliferation is an early component of the activation of macrophage lineage foam cells by agents such as macrophage-CSF (M-CSF) (also known as CSF-1) and granulocyte-macrophage CSF (GM-CSF) (25).…”