Rheumatoid arthritis and schizophrenia: a negative association at a dimensional level

Gorwood, P.; Pouchot, J.; Vinceneux, P; Puéchal, Xavier; Flipo, René‐Marc; Bandt, M. De; Adès, J.

doi:10.1016/s0920-9964(03)00017-3

Cited by 64 publications

(44 citation statements)

References 36 publications

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“…17,71 The nonsynonymous marker, rs40401, is reported to be associated with rheumatoid arthritis 72 that is negatively correlated with schizophrenia. 73 In summary, we present evidence that variants in and around IL3 are associated with schizophrenia in the ISHDSF, ICCSS and ITRIO samples. Specifically, the associations are sex-specific and depend on FH for schizophrenia.…”

Section: Discussionmentioning

confidence: 64%

Interleukin 3 and schizophrenia: the impact of sex and family history

et al. 2006

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Section: Discussionmentioning

confidence: 64%

Interleukin 3 and schizophrenia: the impact of sex and family history

et al. 2006

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“…205 In contrast with an increased incidence of MDD in RA, a decreased risk of schizophrenia has been reported in patients with RA. 206 The development of psychiatric symptoms in patients with RA may be, at least in part, the result of chronic physical symptoms such as pain and disability. 207,208 RA seems to be associated with clinically significant psychiatric syndromes in patients with the most severe disabling 209 However, other psychological, biological and environment factors may be required for development of depressive symptoms in patients with RA.…”

mentioning

confidence: 99%

Brain-immune interactions and disease susceptibility

2005

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Many studies have established the routes by which the immune and central nervous (CNS) systems communicate. This network of connections permits the CNS to regulate the immune system through both neuroendocrine and neuronal pathways. In turn, the immune system signals the CNS through neuronal and humoral routes, via immune mediators and cytokines. This regulatory system between the immune system and CNS plays an important role in susceptibility and resistance to autoimmune, inflammatory, infectious and allergic diseases. This review focuses on the regulation of the immune system via the neuroendocrine system, and underlines the link between neuroendocrine dysregulation and development of major depressive disorders, autoimmune diseases and osteoporosis.

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“…Such a process proposes that individuals with schizophrenia demonstrate elevated immune parameters and even appear in some cases to be less responsive to conventional psychopharmacological management [10,12]. The autoimmune hypothesis is also strengthened by the finding of increased autoimmune disease in relatives of schizophrenia [13] and the inverse relationship of schizophrenia with rheumatoid arthritis (RA) [14]. While this latter association is somewhat counterintuitive, it has been hypothesized that they share a common immune etiology and that once an individual is affected by one of the diseases then they become relatively immune to the other [15].…”

Section: Cytokinementioning

confidence: 99%

“…More specifically, several explanations have been proposed to explain this ''negative association'' at the immune system level. These explanations include for example factors of prostaglandin synthesis, T-and B-lymphocytes activity, serum interleukin receptor concentrations, IGF-II levels and HLA polymorphism differences (reviewed in [14]). The case for a dysfunction of the immunological system in schizophrenia has also been strengthened by the observation in the 1960s of abnormal lymphocytes in peripheral blood and bone marrow of schizophrenia patients (and family members).…”

Section: Cytokinementioning

confidence: 99%