Rheumatoid arthritis in American Indians and Alaska Natives: A review of the literature

Ferucci, Elizabeth D.; Templin, David; Lanier, Anne P.

doi:10.1016/j.semarthrit.2004.08.003

Cited by 117 publications

(77 citation statements)

References 33 publications

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“…Variability in the phenotypic expression of many autoimmune diseases between different ethnicities has long been recognized; in NAN populations autoimmune disease is generally recognized to be severe 2,3,4 . At the very least, descriptions of disparate burdens of disease can help guide public health policy, and direct increased health resources to affected ethnic groups.…”

Section: The Value Of Studying Clinical and Serologic Phenotypes In Nmentioning

confidence: 99%

The Value of Studying Clinical and Serologic Phenotypes in North American Native Populations with Autoimmune Disease

Peschken

2013

J Rheumatol

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Section: The Value Of Studying Clinical and Serologic Phenotypes In Nmentioning

confidence: 99%

The Value of Studying Clinical and Serologic Phenotypes in North American Native Populations with Autoimmune Disease

Peschken

2013

J Rheumatol

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“…33,34 However, it is unknown if the presence of the activatory B telomeric genes increases susceptibility to autoimmune diseases prevalent in indigenous peoples throughout the Americas. [35][36][37][38] Nonetheless, North American Aboriginal ancestry is also associated with a reduced progression to chronic HCV infection. [15][16][17][18] While data on HCV sequelae in other indigenous peoples of the Americas are lacking, the possibility that inherited KIR gene profiles could contribute to these disease patterns is strengthened by the observation that similarities exist between the KIR gene profiles of this Aboriginal cohort and those reported in association with spontaneous clearance of HCV.…”

Section: Current Kir Genetic Profiles May Reflect Historical Immune Smentioning

confidence: 99%

The potential influence of KIR cluster profiles on disease patterns of Canadian Aboriginals and other indigenous peoples of the Americas

et al. 2011

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Genetic differences in immune regulators influence disease resistance and susceptibility patterns. There are major health discrepancies in immune-mediated diseases between Caucasians and Canadian Aboriginal people, as well as with other indigenous people of the Americas. Environmental factors offer a limited explanation as Aboriginal people also demonstrate a rare resistance to chronic hepatitis C virus infection. Killer immunoglobulin-like receptors (KIRs) are known modulators of viral responses and autoimmune diseases. The possibility that variation in KIR cluster profiles contribute to the health outcomes of Aboriginal people was evaluated with Canadian Caucasian (n¼93, population controls) and Aboriginal (n¼86) individuals. Relative to Caucasians, the Aboriginal KIR cluster displayed a greater immune activating phenotype associated with genes of the B haplotype situated within the telomeric region. In conjunction, there was a decrease in the genes of the B haplotype from the centromeric region. Caucasian and Aboriginal cohorts further demonstrated distinct genotype and haplotype relationships enforcing the disconnect between the B haplotype centromeric and telomeric regions within the Aboriginal population. Moreover, Caucasian KIR cluster patterns reflected studies of Caucasians globally, as well as Asians. In contrast, the unique pattern of the Canadian Aboriginal cohort mirrored the phenotype of other indigenous peoples of the Americas, but not that of Caucasians or Asians. Taken together, these data suggest that historically indigenous peoples of the Americas were subject to immune selection processes that could be influencing the current disease resistance and susceptibility patterns of their descendents.

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“…Although increased rates of rheumatoid arthritis in First Nations populations relative to the general population have been documented in cohort studies (2)(3)(4)(5), less is known about rates of systemic autoimmune rheumatic diseases (SARDs), including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjö gren's syndrome, and idiopathic inflammatory myopathies. Increased prevalence of SLE in First Nations populations relative to the general population has been identified in Canadian populations in one region in Alberta (6), one region in British Columbia (7), and in Manitoba (8), as well as in Alaskan Indian populations (9), and in the Crow, Arapahoe, and Sioux Nations in the US (10).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada

Barnabe

Joseph

Bélisle

et al. 2011

Arthritis Care & Research

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Objective. To estimate the population-based prevalence of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) in Alberta, Canada, stratified by First Nations status. Methods. Physician billing claims and hospitalization data for the province of Alberta (1994 -2007) were used to ascertain cases of SLE and SSc using 3 case definitions. A latent class Bayesian hierarchical regression model was employed to account for the imperfect sensitivity and specificity of billing and hospitalization data in case ascertainment. We accounted for demographic factors, estimating prevalence rates for the First Nations and non-First Nations populations by sex, age group, and location of residence (urban/rural). Results. Our model estimated the prevalence of SLE in Alberta to be 27.3 cases per 10,000 females (95% credible interval [95% CrI] 25.9 -28.8) and 3.2 cases per 10,000 males (95% CrI 2.6 -3.8). The overall prevalence of SSc in Alberta was 5.8 cases per 10,000 females (95% CrI 5.1-6.5) and 1.0 case per 10,000 males (95% CrI 0.7-1.4). First Nations females over 45 years of age had twice the prevalence of either SLE or SSc relative to non-First Nations females. There was also a trend toward higher overall SLE prevalence in urban dwellers, and higher overall SSc prevalence in rural residents. Conclusion. First Nations females older than 45 years of age have an increased prevalence of either SLE or SSc. This may reflect a true predominance of autoimmune rheumatic diseases in this demographic, or may indicate systematic differences in health care delivery.

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Rheumatoid arthritis in American Indians and Alaska Natives: A review of the literature

Cited by 117 publications

References 33 publications

The Value of Studying Clinical and Serologic Phenotypes in North American Native Populations with Autoimmune Disease

The Value of Studying Clinical and Serologic Phenotypes in North American Native Populations with Autoimmune Disease

The potential influence of KIR cluster profiles on disease patterns of Canadian Aboriginals and other indigenous peoples of the Americas

Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada

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