Rheumatoid Arthritis Involved in the Ear Drum

Tavernier, L; Ranfaing, E

doi:10.1097/mao.0b013e3181d2f039

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…On the other hand, there is an increased risk of developing rheumatoid nodules and vasculitis in RA patients who are smokers leading to increased rate of both CHL and SNHL [ 4 , 20 , 22 ]. Dikici O, et al .…”

Section: Environmental Factorsmentioning

confidence: 99%

“…There is no consensus regarding the management of hearing impairment in patients with rheumatoid arthritis. Based on empirical grounds, treatment with oral steroid plus cessation of ototoxic drugs should be initiated [ 18 , 20 , 33 , 38 ]. Under special circumstances, intratympanic application of steroids with optimized dosage may result in better response (frequencies over 2000 Hz) [ 38 ].…”

Section: Managementmentioning

confidence: 99%

“…Western-blot (WB) for anticochlear autoantibodies) clarifies the pathogenesis of the disease and may be a lead to earlier diagnosis [ 41 , 42 ]. When there is a clinical suspicion of serous otitis, radiographic evaluation of affected ear may be beneficial to diagnose RA nodules [ 20 ]. Patients and their families should be aware of the noxious effects of smoking on the inner ear which can deteriorate the condition [ 12 ].…”

Section: Managementmentioning

confidence: 99%

“… Different pathologies of hearing impairment in Rheumatoid Arthritis. (Data were extracted from references 2 , 4 , 9 - 15 , 20 ) …”

Section: Fig (1)mentioning

confidence: 99%

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Is Hearing Impairment Associated with Rheumatoid Arthritis? A Review

Emamifar¹,

Bjøerndal²,

Hansen³

2016

TORJ

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Background:Rheumatoid arthritis (RA) is a systemic, inflammatory disease that affects 1% of the population. The auditory system may be involved during the course of disease; however the association of RA and hearing impairment has not been clearly defined. Objective: The objective of this review is to evaluate published clinical reports related to hearing impairment in patients with RA. Furthermore, we discuss possible pathologies and associated factors as well as new treatment modalities. Method:A thorough literature search was performed using available databases including Pubmed, Embase, Cochrane and ComDisDome to cover all relative reports. The following keywords were used: hearing loss, hearing difficulties, hearing disorders, hearing impairment, sensorineural hearing loss, conductive hearing loss, mixed hearing loss, autoimmune hearing loss, drug ototoxicity, drug-induced hearing loss, hearing test, audiometry, auditory dysfunction and rheumatoid arthritis. Conclusion:Based on our review it can be postulated that patients with RA are at higher risk of hearing impairment compared to healthy subjects in their course of the disease. The hearing impairment in RA seems to be a multifactorial condition; however the mechanisms of injury, as well as the relative risk factors, are not completely clear. This review can aid to clarify this condition and is a guide for further evaluation. To the best of our knowledge, this is the first review of hearing impairment in RA.

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Section: Environmental Factorsmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

“… Different pathologies of hearing impairment in Rheumatoid Arthritis. (Data were extracted from references 2 , 4 , 9 - 15 , 20 ) …”

Section: Fig (1)mentioning

confidence: 99%

See 2 more Smart Citations

Is Hearing Impairment Associated with Rheumatoid Arthritis? A Review

Emamifar¹,

Bjøerndal²,

Hansen³

2016

TORJ

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“…Hearing impairment has been reported in patients with autoimmune diseases including rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE), and vasculitis [1][2][3][4][5][6][7][8][9][10]. Among autoimmune diseases, previous studies have described the association between hearing impairment and RA [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. While hearing impairment has been reported to occur in up to 60% of patients with RA, its pathogenesis is not clear [11].…”

Section: Introductionmentioning

confidence: 99%

Idiopathic Inflammatory Arthritis in the Auditory Canal in a Patient With Hearing Impairment: A Case Report and Literature Review

2022

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Inflammatory arthritis can affect the auditory system during the disease course. Although most cases show asymptomatic hearing impairment, it can result in hearing loss. Here we describe the case of a 70-year-old female with hearing impairment associated with idiopathic inflammatory arthritis in her auditory system. She had suffered from hearing difficulties for decades; however, the causes of her hearing impairment had not been evaluated. Pure tone audiometry showed severe sensorineural hearing loss requiring a cochlear implant. The workup for the cochlear implant revealed erosive changes in the incudomalleolar and incudostapedial joints with soft tissue swelling on temporal bone computed tomography. Bone pathology revealed plasmacytic infiltration and granulomatous inflammation. Laboratory examinations showed elevated levels of inflammatory markers; otherwise, she had negative results for all autoantibodies. In patients with idiopathic hearing loss, inflammatory arthritis of the middle ear without peripheral arthritis can provide a clue regarding the cause of the hearing loss.

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Ossicular Bone Damage and Hearing Loss in Rheumatoid Arthritis: A Correlated Functional and High Resolution Morphometric Study in Collagen-Induced Arthritic Mice

Chen¹,

Schwander²,

Barbe³

et al. 2016

PLoS ONE

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Globally, a body of comparative case-control studies suggests that rheumatoid arthritis (RA) patients are more prone to developing hearing loss (HL). However, experimental evidence that supports this hypothesis is still lacking because the human auditory organ is not readily accessible. The aim of this study was to determine the association between bone damage to the ossicles of the middle ear and HL, using a widely accepted murine model of collagen-induced arthritis (RA mice). Diarthrodial joints in the middle ear were examined with microcomputer tomography (microCT), and hearing function was assessed by auditory brainstem response (ABR). RA mice exhibited significantly decreased hearing sensitivity compared to age-matched controls. Additionally, a significant narrowing of the incudostapedial joint space and an increase in the porosity of the stapes were observed. The absolute latencies of all ABR waves were prolonged, but mean interpeak latencies were not statistically different. The observed bone defects in the middle ear that were accompanied by changes in ABR responses were consistent with conductive HL. This combination suggests that conductive impairment is at least part of the etiology of RA-induced HL in a murine model. Whether the inner ear sustains bone erosion or other pathology, and whether the cochlear nerve sustains pathology await subsequent studies. Considering the fact that certain anti-inflammatories are ototoxic in high doses, monitoring RA patients’ auditory function is advisable as part of the effort to ensure their well-being.

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Rheumatoid Arthritis Involved in the Ear Drum

Cited by 5 publications

References 3 publications

Is Hearing Impairment Associated with Rheumatoid Arthritis? A Review

Is Hearing Impairment Associated with Rheumatoid Arthritis? A Review

Idiopathic Inflammatory Arthritis in the Auditory Canal in a Patient With Hearing Impairment: A Case Report and Literature Review

Ossicular Bone Damage and Hearing Loss in Rheumatoid Arthritis: A Correlated Functional and High Resolution Morphometric Study in Collagen-Induced Arthritic Mice

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