Rheumatoid arthritis is associated with exacerbated body composition deterioration in Kazakh females

Kasher, Melody; Gabdulina, Gulzhan; Beissebayeva, Aliya; Mussabaeva, Dana; Tokarev, Alexander; Sarssenbayeva, Meruert; Omarova, Kamka; Mominova, Gulmira; Livshits, Gregory

doi:10.1016/j.nut.2019.06.007

Cited by 6 publications

(6 citation statements)

References 49 publications

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“…It is also a common condition in RA with a prevalence of 15–32% according to a meta-analysis [ 67 ]. Many studies have supported the idea that RA patients have lower skeletal muscle mass resulting in a higher prevalence of sarcopenia as compared with those without RA [ 26 , 31 , 68 , 69 ]. As shown in Table 2 , sarcopenia in RA is clinically meaningful, since it is associated with the incidence of low bone mineral density, falls, and fractures [ 36 , 37 ].…”

Section: Rheumatoid Arthritis and Sarcopeniamentioning

confidence: 99%

Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review

Tizaoui

Terrazzino

et al. 2020

IJMS

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Sarcopenia refers to a decrease in skeletal muscle mass and function. Because sarcopenia affects mortality, and causes significant disability, the clinical importance of sarcopenia is emerging. At first, sarcopenia was recognized as an age-related disease but, recently, it has been reported to be prevalent also in younger patients with autoimmune diseases. Specifically, the association of sarcopenia and autoimmune diseases such as rheumatoid arthritis has been studied in detail. Although the pathogenesis of sarcopenia in autoimmune diseases has not been elucidated, chronic inflammation is believed to contribute to sarcopenia, and moreover the pathogenesis seems to be different depending on the respective underlying disease. The definition of sarcopenia differs among studies, which limits direct comparisons. Therefore, in this review, we cover various definitions of sarcopenia used in previous studies and highlight the prevalence of sarcopenia in diverse autoimmune diseases including rheumatoid arthritis, spondyloarthritis, systemic sclerosis, inflammatory bowel disease, and autoimmune diabetes. In addition, we cover the pathogenesis and treatment of sarcopenia in autoimmune and rheumatic diseases. This review provides a comprehensive understanding of sarcopenia in various autoimmune diseases and highlights the need for a consistent definition of sarcopenia.

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Section: Rheumatoid Arthritis and Sarcopeniamentioning

confidence: 99%

Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review

Tizaoui

Terrazzino

et al. 2020

IJMS

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“…The relationship between muscle and bone remains incompletely understood. More recent cross-sectional studies revealed the association of decreased skeletal muscle with lower bone mineral density, 9,31 osteoporosis, 32,33 bone erosion 34 and joint destruction. 9,14 Systemic inflammation in RA is thought to be a pathogenesis link between muscle wasting and bone loss.…”

Section: Discussionmentioning

confidence: 99%

Reduced skeletal muscle independently predicts 1-year aggravated joint destruction in patients with rheumatoid arthritis

Lin

Liu

et al. 2020

Therapeutic Advances in Musculoskeletal

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Background: Numerous cross-sectional studies have reported the associations between rheumatoid arthritis (RA) and reduced skeletal muscle. We firstly explored the dynamic change of skeletal muscle and its effect on RA clinical outcomes in a real-world prospective cohort. Methods: Consecutive RA patients were treated according to the treat-to-target strategy and completed at least 1-year follow up. Clinical data and muscle index (assessed by bioelectric impedance analysis) were collected at baseline and visits at 3, 6, 9 and 12 months. Myopenia was defined by appendicular skeletal muscle mass index ⩽7.0 kg/m2 in men and ⩽5.7 kg/m2 in women. A 1-year radiographic progression as primary outcome was defined by a change in the total Sharp/van der Heijde modified score ⩾0.5 units. Results: Among 348 recruited patients, 315 RA patients (mean age 47.9 years, 84.4% female) completed 1-year follow up. There were 143 (45.4%) RA patients showing myopenia at baseline. Compared with those without baseline myopenia, RA patients with baseline myopenia had higher rate of 1-year radiographic progression (43.4% versus 21.5%, all p < 0.05). Baseline myopenia was an independent risk factor for 1-year radiographic progression with adjusted odds ratio (AOR) of 2.5-fold, especially among RA patients in remission at baseline both defined by Disease Activity Score in 28 joints (DAS28) including C-reactive protein (DAS28-CRP) or erythrocyte sedimentation rate (DAS28-ESR) with AOR of 18.5~42.9-fold. Further analysis of six subtypes of dynamic skeletal muscle change showed that newly acquired myopenia at endpoint was associated with radiographic progression (AOR of 5.4-fold). Conclusions: Reduced skeletal muscle is an independent predicting factor for 1-year aggravated joint destruction, especially in remission RA. The importance of dynamic monitoring of skeletal muscle and muscle improvement therapy are worth exploration.

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“…Ngai et al reported that bio-impedance was correlated with BMD using whole-body single frequency (50 kHz) bio-impedance measurements in men and postmenopausal women [ 40 ]. Several recent studies investigated the relationship between osteoporosis and PhA [ 15 , 19 , 20 , 21 ]. The authors of a large-scale general population study suggested that PhA could be a predictor of osteoporosis unaffected by age and sex [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Malnutrition, particularly protein deficiency, contributes to the development of osteoporotic fractures by altering muscle function and reducing bone mass [ 17 , 18 ]. However, few studies have applied PhA to estimate the association with BMD [ 15 , 19 , 20 , 21 ]. Furthermore, few studies have statistically analyzed the relationship between PhA and age, which affects bone density in patients with CKD.…”

Section: Introductionmentioning

confidence: 99%

Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5

et al. 2023

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Background: Low bone mass is common in malnourished patients with chronic kidney disease (CKD) and can lead to a higher risk of fractures. Elderly and CKD patients have the same risk factors for protein-energy wasting, sarcopenia, and osteoporosis. Here, we investigated the association between phase angle (PhA) and bone mineral density (BMD) in dialysis-naïve patients with CKD stage 5 (CKD5) and identified a statistical relationship between PhA and age, which affects bone density. Methods: Bio-impedance spectroscopy for evaluating body composition and PhA and dual-energy X-ray absorptiometry for determining the BMD were simultaneously performed in 167 consecutive patients (mean age, 59.65 ± 13.98 years; women, 40.1%). Two-way analysis of variance (ANOVA) was conducted to assess the potential interaction effect of PhA and age on femoral neck BMD (FN-BMD). Results: Our results showed that PhA and age were independently associated with FN-BMD and T-score in multiple linear regressions analyses. A significant interaction effect of PhA and age on FN-BMD was found on two-way ANOVA (p = 0.028). The average BMD values for the first and second tertiles of the PhA were higher in the young versus elderly group, whereas patients in the elderly group had higher BMD in the third tertiles. Conclusions: A relationship was noted between PhA and BMD in patients with advanced-stage CKD. The effect of PhA level on FN-BMD differed between elderly and young patients. Our study suggested that higher PhA levels could be a marker explaining the maintenance of good bone health in elderly patients with CKD5. Further longitudinal analyses are needed to determine whether PhA predicts the risk of CKD-MBD-related fractures during CKD progression.

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Rheumatoid arthritis is associated with exacerbated body composition deterioration in Kazakh females

Cited by 6 publications

References 49 publications

Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review

Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review

Reduced skeletal muscle independently predicts 1-year aggravated joint destruction in patients with rheumatoid arthritis

Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5

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