Rheumatoid Arthritis: Laboratory Models of the Disease

Abstract

Адрес для переписки:Орловская Ирина Анатольевна ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии» 630099, Россия, г. Новосибирск, ул. Ядринцевская, 14. Тел.: 8 (913) 748-60-99. E-mail:irorl@mail.ru Address for correspondence:Orlovskaya Irina Anatolievna Research Institute of Basic and Clinical Immunology, 630099, Russian Federation, Novosibirsk, Yadrintsevskaya str., Образец цитирования: И.А. Орловская, Д.Д. Цырендоржиев, С.Н. Щелкунов, «Ревматоидный артрит: лабораторные модели заболевания» // Медицинская иммунология, 2015. Т. 17, № 3. С. 203-210. doi: 10.15789/1563-0625-2015-3-203-210 © Орловская И.А. и соавт., 2015 Immunologiya, 2015, Vol. 17, no. 3, pp. 203-210. doi: 10.15789/1563-0625-2015 Резюме. Эффективным подходом к исследованию ревматоидного артрита (РА) является создание и использование моделей животных. Экспериментальное изучение различных аспектов формирова-ния и течения РА, включая ранний РА, позволяют приблизиться к пониманию этиопатогенетических механизмов заболевания человека. В обзоре рассматриваются известные в настоящее время модели заболевания. Использование этих моделей для тестирования потенциальных терапевтических пре-паратов поможет прогнозировать их эффективность. Abstract. The establishment and application of animal models represent effective tools for research in rheumatoid arthritis (RA) pathogenesis. Animal models that replicate various mechanisms reflecting all aspects of RA, including early RA pathology, have provided important insights into studying etiology and pathogenetic mechanisms of RA in humans. This review article was compiled in order to give an introduction to the current state of RA models. Application of these experimental disorders for testing potential therapeutic approaches will help to make better predictions for drug efficiency in human RA. Keywords: rheumatoid arthritis, experimental models, pathogenesis, etiology, animals, immunology БлагодарностиРабота выполнена при финансовой поддержке Российского научного фонда (грант № 14-15-00050).

Adjuvant-Induced Arthritis in Guinea Pigs

“…It is known that RA is a disease characterized by a diversity of molecular mechanisms and the sensitivity of individuals to different therapeutic agents. Therefore, the use of different laboratory models is advisable when testing potential antiarthritic drugs [ 1 , 2 , 3 , 5 , 6 , 11 ]. Currently, the most well studied induced arthritis models are based on certain lines of mice and rats [ 1 , 2 , 5 , 6 ].…”

“…Therefore, the use of different laboratory models is advisable when testing potential antiarthritic drugs [ 1 , 2 , 3 , 5 , 6 , 11 ]. Currently, the most well studied induced arthritis models are based on certain lines of mice and rats [ 1 , 2 , 5 , 6 ]. However, none of these models reflect all the characteristic features of RA in humans [ 5 ] and, therefore, the search for additional experimental models of RA remains relevant.…”

“…Most often, the disease attacks older people. The reasons that cause the development of arthritis remain not well established, possibly because of their multiplicity [ 1 , 2 , 3 , 4 ].…”

“…Various animal models are used to study the pathogenesis of RA and develop drugs effective against the disease. The vast majority of research on the induction and therapy of RA are performed on certain lines of mice and rats [ 1 , 2 , 5 , 6 ]. This is first of all due to the good state of knowledge on and homogeneity of these animals and the large number of available immunological reagents and test systems.…”

“…This is first of all due to the good state of knowledge on and homogeneity of these animals and the large number of available immunological reagents and test systems. However, none of these models fully reflects all aspects of the development of human RA [ 1 , 5 , 7 ] and, therefore, preclinical studies of potential antiarthritic drugs should be carried out in various animal models.…”