Rheumatoid Arthritis Veiled by Sickle Beta-Thalassemia: A Rare Immunological Association Delaying Diagnosis

Abstract

Sickle beta-thalassemia is a rare variant of sickle cell disease (SCD) that manifests with milder symptoms. Musculoskeletal complications arising from this condition can mimic inflammatory arthritis and hence delay the diagnosis of rheumatoid arthritis (RA) until irreversible damage has been done. RA has been reported to occur with SCD but there is no documented literature thus far on its co-occurrence with sickle beta-thalassemia. This case report elucidates the etiopathogenesis, clinical manifestations, and challenges encountered with the diagnosis and management of RA in a patient with sickle beta thalassemia.

Navigating the Diagnosis and Management of Rheumatoid Arthritis in the Context of Sickle Cell Disease: A Dual Challenge

“…The use of hydroxyurea with steroids remains a topic of debate as it can further lead to immunosuppression. NSAIDs tend to worsen the renal damage that may be caused by sickle cell disease and this complicates the treatment for pain [ 6 ]. There is no known adverse effect of concomitant use of hydroxyurea and hydroxychloroquine [ 7 ].…”