Rhinitis/Bronchopneumonia Syndrome in Irish Wolfhounds

Clercx, Cécile; Reichler, Iris M; Peeters, Dominique; McEntee, Kathleen; German, Alexander J.; Dubois, Jacqueline; Schynts, E; Schaaf‐Lafontaine, Nicole; Willems, Tatiana; Jorissen, Mark; Day, Michael

doi:10.1111/j.1939-1676.2003.tb02524.x

Cited by 28 publications

(9 citation statements)

References 16 publications

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“…2,57 Similarly, an increased incidence of hydrocephalus has been associated with primary ciliary dyskinesia in certain dog breeds. 20,22,29,80 The mechanical function of ependymal flow would be most important in narrow passageways, therefore making the cerebral aqueduct a critical location for an intact and functional ependymal lining. Obstruction of the aqueduct would be more likely during embryonic development, when the physical size of the lumen is small.…”

Section: Discussionmentioning

confidence: 99%

Congenital Hydrocephalus in Genetically Engineered Mice

et al. 2011

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There is evidence that genetic factors play a role in the complex multifactorial pathogenesis of hydrocephalus. Identification of the genes involved in the development of this neurologic disorder in animal models may elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans. The authors report here a brief summary of findings from 12 lines of genetically engineered mice that presented with autosomal recessive congenital hydrocephalus. This study illustrates the value of knockout mice in identifying genetic factors involved in the development of congenital hydrocephalus. Findings suggest that dysfunctional motile cilia represent the underlying pathogenetic mechanism in 8 of the 12 lines (Ulk4, Nme5, Nme7, Kif27, Stk36, Dpcd, Ak7, and Ak8). The likely underlying cause in the remaining 4 lines (RIKEN 4930444A02, Celsr2, Mboat7, and transgenic FZD3) was not determined, but it is possible that some of these could also have ciliary defects. For example, the cerebellar malformations observed in RIKEN 4930444A02 knockout mice show similarities to a number of developmental disorders, such as Joubert, Meckel-Gruber, and Bardet-Biedl syndromes, which involve mutations in ciliarelated genes. Even though the direct relevance of mouse models to hydrocephalus in humans remains uncertain, the high prevalence of familial patterns of inheritance for congenital hydrocephalus in humans suggests that identification of genes responsible for development of hydrocephalus in mice may lead to the identification of homologous modifier genes and susceptibility alleles in humans. Also, characterization of mouse models can enhance understanding of important cell signaling and developmental pathways involved in the pathogenesis of hydrocephalus.

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Section: Discussionmentioning

confidence: 99%

Congenital Hydrocephalus in Genetically Engineered Mice

et al. 2011

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“…These authors conclude that GDV may be partly mediated through the inheritance of a particular body shape (deep chest) or tempera- Neither figures on incidence nor on prevalence in Irish Wolfhounds are available in the literature. In the most extensive study (16), all described cases (n=28) belonged to six bloodlines that all shared common ancestors, suggesting that this disorder could have a genetic background. According to (12), the mode of inheritance may follow a simple autosomal recessive pattern.…”

Section: It Was First Shown In 1995 That Pss In Irishmentioning

confidence: 99%

Lifespan and disease predispositions in the Irish Wolfhound: A review

Urfer¹,

Gaillard²,

Steiger³

2007

Veterinary Quarterly

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“…The best known predisposed respiratory disease is rhinitis/bronchopneumonia syndrome, where a chronic rhinitis is the primary disease process while bronchopneumonia develops secondarily, with the disease typically occurring in young dogs and often being present from birth (Clercx et al . , Wilkinson ). Immunodeficiency was proposed as the cause of the rhinitis/bronchopneumonia syndrome in three related dogs in one study (Leisewitz et al .…”

Section: Introductionmentioning

confidence: 99%

Aspiration pneumonia in the Irish wolfhound: a possible breed predisposition

Greenwell¹,

Brain²

2014

J of Small Animal Practice

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Background Anecdotal reports suggest a recent high prevalence of aspiration pneumonia in Irish wolfhounds, prompting further investigation into the incidence of the disease in this breed. Objectives To investigate the possibility that Irish wolfhounds have an increased incidence of aspiration pneumonia, and to consider possible predisposing causes in this breed. Methods Retrospective review of medical records from the Small Animal Specialist Hospital, Sydney, from January 2008 to December 2012 inclusive to determine the total hospital incidence and individual breed incidences of aspiration pneumonia. Results The total hospital incidence of aspiration pneumonia was 0 · 5%. The Irish wolfhound had the highest breed incidence, with 9 of 25 dogs (36%) diagnosed with aspiration pneumonia. Four of the Irish wolfhounds had a predisposing cause identified; one having a choking episode, one having gastric bloat, while two were diagnosed with laryngeal paralysis after it was specifically investigated because of clinical suspicion. Five had no underlying cause of their aspiration pneumonia determined. Clinical Significance On the basis of the hospital population studied, the Irish wolfhound has a high incidence of aspiration pneumonia. Further investigation into the possible predisposing cause(s) in this breed is warranted.

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Rhinitis/Bronchopneumonia Syndrome in Irish Wolfhounds

Cited by 28 publications

References 16 publications

Congenital Hydrocephalus in Genetically Engineered Mice

Congenital Hydrocephalus in Genetically Engineered Mice

Lifespan and disease predispositions in the Irish Wolfhound: A review

Aspiration pneumonia in the Irish wolfhound: a possible breed predisposition

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