Rhinitis medicamentosa

Scadding, Glenis

doi:10.1111/j.1365-2222.1995.tb01068.x

Cited by 38 publications

(29 citation statements)

References 26 publications

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“…Moreover, there are some studies that assess nasal airflow resistance (1606). A prolonged use (>10 days) of intranasal vasoconstrictors may lead to tachyphylaxis, a rebound swelling of the nasal mucosa, and to Ôdrug-induced rhinitisÕ (rhinitis medicamentosa; 159, 160,162,1607,1608).…”

Section: 27mentioning

confidence: 99%

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Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

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3,867

1,761

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Section: 27mentioning

confidence: 99%

“…• reserpine (154) The term rhinitis medicamentosa (159)(160)(161) applies to the rebound nasal obstruction which develops in patients who use intranasal vasoconstrictors chronically. The pathophysiology of the condition is unclear; however, vasodilatation and intravascular edema have both been implicated.…”

Section: Drug-induced Rhinitismentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

Self Cite

3,867

1,761

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“…This drugs can block the binding of leukotrienes to CysLT1 receptors 21 . Montelukast is the most commonly used inhibitor of the leukotriene pathway because of its ease of use, good safety profile, and once-daily regimen 20,22 .…”

Section: Antileukotrienesmentioning

confidence: 99%

“…• Leukotriene inhibitors (Montelukast)-is the most commonly used inhibitor of the leukotriene pathway 20 .…”

Section: Allergic Rhinitis Can Be Treated Bymentioning

confidence: 99%

Montelukast in Allergic Rhinitis: A Review

2013

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“…The most common remedy most patients resort to for nasal obstruction is nasal decongestant sprays or drops which work via alpha-adrenergic effects; unfortunately, these are associated with rebound congestion phenomena, which lead to repeated use and subsequent "rhinitis medicamentosa" [8,9]. Consequently, it would be beneficial if a nasal spray could be developed based on other mechanisms, which did not have the associated rebound effects.…”

Section: Introductionmentioning

confidence: 99%

A herbal composition of Scutellaria baicalensis and Eleutherococcus senticosus shows vasocontrictive effects in an ex-vivo mucosal tissue model and in allergic rhinitis patients

et al. 2017

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Background: This study aimed to investigate the nasal decongestive efficacy of an alternative to pharmacotherapy, a herbal nasal spray composed of Scutellaria baicalensis and Eleutherococcus senticosus.Methods: Scutellaria baicalensis and Eleuthrococcus senticosus and control solutions were applied separately to isolated mucosal tissue from inferior turbinates. Vasoconstriction was measured as a change in isometric tension. Moreover, twenty allergic rhinitis patients with nasal stuffiness participated in a randomized, placebo-controlled clinical study with cross-over design; the same patients served as their placebo control group. Pre-and posttreatment nasal congestion and smell test scores were evaluated for the test and placebo spray using two validated questionnaires, the 5 question nasal congestion questionnaire and the 12 question Brief Smell Identification Test-Version B.Results: In the ex-vivo mucosal tissue, the herbal compounds were demonstrated to induce vasoconstriction when applied at 10 mg/ml concentration. The combination of S. baicalensis and E. senticosus proved effective in relieving patients' nasal congestion and was statistically superior to placebo. No side effects were noted, and there was no difference between the pre-and post-study smell test results. Conclusions:The combined S. baicalensis and E. senticosus herbal nasal spray relieved nasal congestion significantly better than placebo without any side effects.

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Rhinitis medicamentosa

Cited by 38 publications

References 26 publications

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Montelukast in Allergic Rhinitis: A Review

A herbal composition of Scutellaria baicalensis and Eleutherococcus senticosus shows vasocontrictive effects in an ex-vivo mucosal tissue model and in allergic rhinitis patients

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