Rhino-Orbital Cerebral Mucormycosis Causing Temporomandibular Joint Ankylosis: A Case Series of Two Patients

Abstract

Temporomandibular joint ankylosis is caused by trauma, infection, autoimmune, inflammatory joint diseases, and several other minor causes. Mucormycosis causing temporomandibular joint ankylosis has not been reported. We report two cases of temporomandibular joint ankylosis caused by mucormycosis from 2018 to 2022. In both cases, the infection started in the maxilla, then progressed to orbit. After that, involvement of the mastoid process, styloid process, and base of the skull was observed in the first case, while in the second case, there was the involvement of the base of the skull and mandibular ramus. As the temporomandibular joint (TMJ) components are contiguous to the base of the skull, it got affected causing temporomandibular joint ankylosis. Mucormycosis was diagnosed by KOH mount. The smear examination showed aseptate hyphae at 90 0 . Histopathology examination further confirmed mucormycosis. Glycemic control was done by infusing Insulin (both Lantus and regular). The case was managed with aggressive debridement and interpositional arthroplasty with a buccal fat pad. Liposomal amphotericin infusion was also started pre-operatively and continued in the post-operative phase. After 4 years of follow-up, the patient is well and had adequate mouth opening.Mucormycosis infection affecting the TMJ has been reported in the literature. However, this is the first report of a mucormycosis infection resulting in TMJ ankylosis in the literature. The infection should be aggressively managed. Reversals of an immunocompromised state, aggressive surgical management, and antifungal medication are the key factors for the success of the deadly fungal infection.

The role of physiotherapy interventions in the management of temporomandibular joint ankylosis: a systematic review and meta-analysis

“…The etiology of TMJ ankylosis is multifactorial, encompassing various variables such as trauma, infection, inflammation, and congenital anomalies [ 5 ]. Injuries, such as fractures affecting the mandible or temporal bone, can disrupt the complex joint structure and trigger a reparative mechanism that results in abnormal adhesions [ 6 ].…”

“…Fig 5. Forest plot comparing the prevalence of bilateral and unilateral presentation of TMJ ankylosis[18, 20-22, 24-26, 28, 29, 31-33, 35, 37-41] …”