Rhinoscleroma

Lenis, Armando; RUFF, TIBOR; DIAZ, JAIME A.; GHANDOUR, E G

doi:10.1097/00007611-198812000-00029

Cited by 37 publications

(15 citation statements)

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“…Antibiotic treatment is effective but must be prolonged [12,14]. Person-toperson transmission of KR probably occurs via airborne secretions [15]. However, healthy individuals in contact with a patient for many years do not necessarily develop infection [16].…”

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confidence: 99%

Rhinoscleroma: A French National Retrospective Study of Epidemiological and Clinical Features

et al. 2008

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confidence: 99%

Rhinoscleroma: A French National Retrospective Study of Epidemiological and Clinical Features

et al. 2008

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“…K. rhinoscleromatis (Klebsiella tribe III) is an opportunistic, gram‐negative diplobacillus of the family Enterobacteriaceae which, along with K. ozena, represents a biochemically inactive strain of K. pneumoniae . 10–12 Our observations show that, either in culture or in vivo, KR exhibits a complex capsule covered by fimbriae. Fimbriae are responsible for the microorganism's ability to adhere to host cells and, consequently, were scant in cultured Klebsiella and conspicuous in tissue bacteria.…”

Section: Discussionmentioning

confidence: 61%

“…12 With only one exception, the capsular polysaccharides of all Klebsiella serotype III have been found to be of a similar composition, 12–14 and in K. pneumoniae, they have been shown to enable the organism to resist phagocytosis and the bactericidal power of normal serum. 11,12 Because KR has a close biochemical relationship with this strain, it likely shares similar defensive and toxic properties which determine its resistance.…”

Section: Discussionmentioning

confidence: 99%

An Interpretation of the Structural Changes Responsible for the Chronicity of Rhinoscleroma

Canalis

Zamboni

2001

The Laryngoscope

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Several critical changes responsible for the chronicity of rhinoscleroma occur during the proliferative phase of the disease. The majority of these take place in the subepithelium and include: 1) factors leading to the transformation of histiocytes into Mikulicz cells, 2) the inability of these cells to consistently destroy the Klebsiella, 3) their rupture releasing viable Klebsiella, and 4) the intrinsic resistance of the pathogen.

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“…Lastly, the fibrotic or sclerotic stage represents the cicatrization of the lesions, leading to anatomic distortion and stenosis of the affected structures during the proliferative phase (15).…”

Section: Discussionmentioning

confidence: 99%

Rhinoscleroma in Three Siblings

Vozmediano

Armario-Hita

Cabrerizo

2004

Pediatric Dermatology

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Rhinoscleroma is a chronic, granulomatous infectious disease that responds poorly to treatment. In recent years an increasing number of cases have been reported in nonendemic areas, explained largely by major migratory movements. We describe rhinoscleroma in three siblings. They had ulcerated but painless lesions, which bled spontaneously, and hemorrhagic scabs or crusts in their noses. In one child, the lesions had destroyed the entire left nasal ala and alar cartilage and most of the right. Dermatopathologic study identified the Mikulicz macrophages that contained organisms. It is possible that disposing factors could have been the neutropenia common to the three children and their poor living conditions. They were treated with a combination of trimethoprim-sulfamethoxazole and cefalexin, for a period of 3 months. We present this unusual case history of three siblings affected by a process that is relatively infrequent in our area of practice and is not considered very contagious. It is important to recognize the clinical signs characteristic of this disease, the diagnosis of which is not easy. Improvements in living conditions, hygiene, and health standards are essential prerequisites for its control and prevention.

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Rhinoscleroma

Cited by 37 publications

References 0 publications

Rhinoscleroma: A French National Retrospective Study of Epidemiological and Clinical Features

Rhinoscleroma: A French National Retrospective Study of Epidemiological and Clinical Features

An Interpretation of the Structural Changes Responsible for the Chronicity of Rhinoscleroma

Rhinoscleroma in Three Siblings

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