Rhinovirus-induced wheezing in infancy—the first sign of childhood asthma?

Kotaniemi‐Syrjänen, Anne; Vainionpää, Raija; Reijonen, Tiina M.; Waris, Matti; Korhonen, Kaj; Korppi, Matti

doi:10.1067/mai.2003.33

Cited by 372 publications

(461 citation statements)

References 35 publications

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“…Similar to RSV, RV-related respiratory illness during early life has also been associated with a high risk of suboptimal lung health and function later in life [100–102]. Insight on the association between RV-related respiratory illnesses and the risk of future asthma originated from the Childhood Origins of Asthma Study, a prospective birth cohort of term-born infants at high risk of asthma and atopy [103].…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

“…Hospitalisation with RV-related respiratory illness has been associated with a more than 3-fold increase in the rate of recurrent wheeze among healthy term-born infants during the following year [105]. Similarly, hospital presentation and/or admission with an RV-related wheezing illness in childhood is associated with a 3-fold increased risk of subsequent hospitalisation for another respiratory illnesses [106] as well as a more than 4-fold increased risk of subsequent asthma [100]. …”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

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The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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“…Moreover HRVs cause upper respiratory tract infections at all ages and are the main cause of LRTIs leading to hospitalisation in infants and young children outside of the winter RSV bronchiolitis season (Montalbano and Lemanske, 2002;Kotaniemi-Syrjänen et al, 2003;;Hayden, 2004;Korppi et al, 2004;Miller et al, 2007;Wiehler and Proud, 2007;Peltola et al, 2008;Lachowicz-Scroggins et al, 2010;Jartti and Korppi, 2011;Rollinger and Schmidtke,2011;Skevaki et al, 2012;Aya Takeyama et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Ficus religiosa L. bark extracts inhibit human rhinovirus and respiratory syncytial virus infection in vitro

Cagno

Civra

Kumar

et al. 2015

Journal of Ethnopharmacology

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ETHNOPHARMACOLOGICAL RELEVANCE:Ficus religiosa L. is one of the most relevant members of the family of Moraceae. It is the most sacred tree of South Asia, and it is used in traditional Ayurvedic and Unani medicine to cure respiratory disorders like cough, wheezing and asthma. Some studies were performed to investigate the anti-asthmatic potential of F. religiosa bark, leaves and fruit extracts but none of them tested their antiviral activity against viruses responsible for the exacerbation of wheezing and asthma. AIM OF THE STUDY:The present study was undertaken to investigate the antiviral activity of F. religiosa L.extracts against respiratory viruses such as human respiratory syncytial virus (RSV) and human rhinovirus (HRV). MATERIALS AND METHODS:The antiviral activity of F. religiosa L. was tested in vitro by plaque reduction and virus yield assays and the major mechanism of action was investigated by virus inactivation and time-ofaddition assays. RESULTS:F. religiosa L. methanol bark extract was the most active against HRV with an EC 50 of5.52 µg/mL. This extract likely inhibited late steps of replicative cycle. Water bark extract was the most active against RSV with an EC 50 between 2.23 and 4.37 µg/mL. Partial virus inactivation and interference with virus attachment were both found to contribute to the anti-RSV activity. Replication of both viruses was inhibited in viral yield reduction assays. CONCLUSIONS: 3The results of the present study demonstrate that F. religiosa L. is endowed with antiviral activity against RSV and HRV in vitro. Further work remains to be done to identify the active components and to assess the therapeutic potential in vivo. 1.

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“…Since viral illnesses contribute significantly to wheezing in early life, it has been of interest to determine which viruses had the greatest potential of not only producing early life wheezing, but possibly to be associated with the subsequent development of asthma as well. In this regard, a number of evaluations in hospitalized infants indicated that respiratory syncytial virus (RSV) infections had this potential (2,3). However, with the advent of advances in molecular viral technology, it has now been possible to evaluate the contribution of other viruses to asthma development as well.…”

Section: Who Is the Right Patient?mentioning

confidence: 99%

Asthma Therapies Revisited: What Have We Learned?

Lemanske

2009

Proceedings of the American Thoracic Society

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Asthma is a heterogenous disorder related to numerous biologic, immunologic, and physiologic components that generate multiple clinical phenotypes. Further, genetic and environmental factors interact in ways that produce variability in both disease onset and severity and differential expression based on both the age and sex of the patient. Thus, the natural history of asthma is complex in terms of disease expression, remission, relapse, and progression. As such, therapy for asthma is complicated and has been approached from the standpoints of primary, secondary, and tertiary prevention. Presently, asthma cannot be cured but can be controlled in most patients, an indication that most of the success clinical research strategies have realized has been in the area of tertiary prevention. Since for many adult patients with asthma their disease had its roots in early life, much recent research has focused on events during early childhood that can be linked to subsequent asthma development with the hopes of creating appropriate interventions to alter its natural history of expression. These research approaches can be categorized into three questions. Who is the right patient to treat? When is the right time to begin treatment? And finally, what is the appropriate treatment to prescribe?

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Rhinovirus-induced wheezing in infancy—the first sign of childhood asthma?

Abstract: Our results present rhinoviruses as important inducers of wheezing even in infancy. The association with atopy and subsequent asthma calls for reevaluation of the role of rhinoviruses in the development of asthma.

Cited by 372 publications

References 35 publications

The impact of respiratory viruses on lung health after preterm birth

The impact of respiratory viruses on lung health after preterm birth

Ficus religiosa L. bark extracts inhibit human rhinovirus and respiratory syncytial virus infection in vitro

Asthma Therapies Revisited: What Have We Learned?

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