Rhodiola rosea: A Therapeutic Candidate on Cardiovascular Diseases

Chen, Yingqing; Tang, Minli; Yuan, Shi‐Min; Fu, Shuang; Li, Yifei; Li, You; Wang, Qi; Cao, Yongguo; Liu, Jia-Chun; Zhang, Qinggao

doi:10.1155/2022/1348795

Cited by 22 publications

(19 citation statements)

References 71 publications

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“…Rhodiola rosea contains approximately 140 constituents, including salidroside, tyrosol, rosavin, gallic acid, and rosaline [ 16 , 78 ]. Uyeturk et al have reported that Rhodiola rosea extract has preventive effects on testicular ischemia-reperfusion injury [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats

Wei

Huang

Qin

2022

Oxidative Medicine and Cellular Longevity

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Testicular torsion-detorsion results in testicular ischemia-reperfusion injury, which is associated with overgeneration of reactive oxygen species. Salidroside, a major bioactive ingredient extracted from Rhodiola rosea, has strong antioxidant activity. The purpose of this study was to examine the effect of salidroside on testicular ischemia-reperfusion injury. Sixty rats were randomly separated into 3 experimental groups: group A = sham-operated control; group B = testicular ischemia-reperfusion; and group C = testicular ischemia-reperfusion treated with salidroside. The rats in the sham-operated control group received all surgical procedures except testicular torsion-detorsion. The testicular ischemia-reperfusion group underwent 2 hours of left testicular torsion followed by detorsion. The rats in the salidroside-treated group received the same surgical procedure as in testicular ischemia-reperfusion group, but salidroside was injected intraperitoneally at reperfusion. Testicular malondialdehyde content (a reliable index of reactive oxygen species) and protein expression of superoxide dismutase and catalase which are primary antioxidant enzymes in testes were measured at 4 hours after reperfusion. Testicular spermatogenesis was evaluated at 3 months after reperfusion. The malondialdehyde content increased significantly, while superoxide dismutase and catalase protein expression and testicular spermatogenesis reduced significantly in ipsilateral testes of testicular ischemia-reperfusion group, as compared with sham-operated control group. Therapy with salidroside significantly reduced malondialdehyde content and significantly enhanced superoxide dismutase and catalase protein expression and spermatogenesis in ipsilateral testes, as compared with testicular ischemia-reperfusion group. The present findings indicate that treatment with salidroside ameliorates testicular ischemia-reperfusion injury by reducing reactive oxygen species level by upregulating superoxide dismutase and catalase protein expression.

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Section: Discussionmentioning

confidence: 99%

Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats

Wei

Huang

Qin

2022

Oxidative Medicine and Cellular Longevity

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“…Thus, other treatments with improved safety must be identi ed. Prior studies have demonstrated that Chinese herbal medicines have great advantages in the treatment of diabetes [40][41][42], in ammation [43], nervous system diseases [19,[44][45], cancer [46-48], COVID-19 [46], and cardiovascular diseases [50]. Therefore, we turned our attention to Chinese herbal medicines and their prescriptions.…”

Section: Discussionmentioning

confidence: 99%

“…It participates in the hydrolysis of lipid peroxide by scavenging free radicals to protect cells from lipid peroxide accumulation [16]. Prior studies [17][18][19][20] have also reported that traditional Chinese medicine has obvious advantages in the treatment of cardiovascular disease, which can improve the prognosis of patients, reduce the incidence of complications, and improve the safety of the medication. The representative compound preparation for the clinical treatment of CS in China is Shenfu injection (SFI).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Ginsenoside Rg5 on Hypoxia/Reoxygenation- Induced H9c2 Cardiomyocytes by Correcting Free Fatty Acids β- oxidation

Jiang

Fang

Zhang

et al. 2023

Preprint

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Clinically, the in-hospital mortality rate of cardiogenic shock (CS) is approximately 50%. In CS, metabolic pathways in the body undergo “embryonal transformation,” in which metabolic processes transform free fatty acids (FFAs) to glucose. Shenfu injection (SFI) treatment has exhibited a positive effect on cardiogenic shock, and ginsenoside Rg5 (G-Rg5) is the anticardiogenic shock component of SFI. In this study, we aimed to investigate the myocardial protective effect and mechanism of G-Rg5 in myocardial energy metabolism, especially from the perspective of FFA β-oxidation, one of the most crucial lipid metabolism pathways. Cardiomyocytes were exposed to hypoxia-reoxygenation (H/R) and treated with G-Rg5. MTT analysis was used to determine the viability of H9c2 cardiomyocytes under different interventions with G-Rg5. The levels of lactate dehydrogenase (LDH) and FFA were detected using ELISA, and adenosine triphosphate (ATP) was determined using high-performance liquid chromatography (HPLC). Furthermore, the expression of NR4A1 was determined by RT-qPCR, and the levels of AMPKα, p-AMPKα, and GPX4 were detected by western blotting to explore the underlying mechanism. We observed that G-Rg5-protected H9c2 cardiomyocytes exhibited better FFA β-oxidation regulation, thereby producing an increased abundance of ATP. G-Rg5 may correct FFA β-oxidation by regulating the levels of NR4A1, AMPKα, p-AMPKα, and GPX4. Therefore, G-Rg5 is a promising drug for CS treatment.

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“…should be treated as a synonym of R. rosea L., the most reputed species of the Rhodiola genus. Botanical description of the plant as well as information on its distribution, ethnobotany, and medicinal properties is easy to find in the literature [ 65 , 91 , 92 ]. In one study, the HRs of R. sachalinensis were obtained via the infection of leaf explants with R. rhizogenes strain A4.…”

Section: Phenolic and Polyphenolic Antioxidants In Hrsmentioning

confidence: 99%

Hairy Root Cultures as a Source of Phenolic Antioxidants: Simple Phenolics, Phenolic Acids, Phenylethanoids, and Hydroxycinnamates

Malarz

Yudina

Stojakowska

2023

IJMS

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Plant-derived antioxidants are intrinsic components of human diet and factors implicated in tolerance mechanisms against environmental stresses in both plants and humans. They are being used as food preservatives and additives or ingredients of cosmetics. For nearly forty years, Rhizobium rhizogenes-transformed roots (hairy roots) have been studied in respect to their usability as producers of plant specialized metabolites of different, primarily medical applications. Moreover, the hairy root cultures have proven their value as a tool in crop plant improvement and in plant secondary metabolism investigations. Though cultivated plants remain a major source of plant polyphenolics of economic importance, the decline in biodiversity caused by climate changes and overexploitation of natural resources may increase the interest in hairy roots as a productive and renewable source of biologically active compounds. The present review examines hairy roots as efficient producers of simple phenolics, phenylethanoids, and hydroxycinnamates of plant origin and summarizes efforts to maximize the product yield. Attempts to use Rhizobium rhizogenes-mediated genetic transformation for inducing enhanced production of the plant phenolics/polyphenolics in crop plants are also mentioned.

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Rhodiola rosea: A Therapeutic Candidate on Cardiovascular Diseases

Cited by 22 publications

References 71 publications

Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats

Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats

Protective Effect of Ginsenoside Rg5 on Hypoxia/Reoxygenation- Induced H9c2 Cardiomyocytes by Correcting Free Fatty Acids β- oxidation

Hairy Root Cultures as a Source of Phenolic Antioxidants: Simple Phenolics, Phenolic Acids, Phenylethanoids, and Hydroxycinnamates

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