Rhodium Chloride Catalyzed Facile Synthesis of α‐Aminonitriles.

Abstract

The facile synthesis of a series of α-aminonitriles by a one-pot three-component condensation of carbonyl compounds, amines and TMSCN in MeCN in presence of a catalytic amount of rhodium chloride at ambient temperature in high yields is described.

Suzuki–Miyaura Cross‐Coupling Reactions in Aqueous Media: Green and Sustainable Syntheses of Biaryls

“…[30] The same reaction was also studied by Pasha and Jayashankara, who replaced potassium carbonate by tertabutylammonium bromide (TBAB). [31] Although the reaction rates and product yields were similar, their process required extraction with ethyl acetate to isolate the product and expensive TBAB instead of potassium carbonate. Thus, when comparing these two protocols one can designate Kidwai et al's protocol as a real green.…”

The chemical reactivity of naphthols and their derivatives toward α-cyanocinnamonitriles and ethyl α-cyanocinnamates: A review of synthesis, reactions and applications of naphthopyrano

“…Scheme 8 b) Naphtho[2,1-b]pyran derivatives, 5, have been synthesized involving a one pot three-component reaction of an aldehyde, malononitrile and 2-naphthol (4) using catalytic amounts tetra-butyl ammonium bromide (TBABr) under aqueous conditions (Scheme 9) [17]. (5) via a one-pot three-component reaction of aromatic aldehydes, 2-naphthol (4), and malononitrile at room temperature [18].…”

Boric Acid Catalysed Synthesis of α-Aminonitriles by a Three-Component Reaction at Room Temperature

“…The efficiency of the reaction has been increased by the use of various catalysts. [7][8][9][10][11][12][13][14][15][16][17][18][19] However, these methodologies show varying degrees of success as well as limitations due to the use of toxic organic solvents, expensive catalysts, prolonged reaction times, and the requirement for special apparatus, or harsh reaction conditions. Thus, there is a need for an alternative route for the production of α-aminonitriles, which overcomes these limitations.…”