Rhodococcus equi Infections of Humans

Verville, Thomas D.; Huycke, Mark M.; Greenfield, Ronald A.; Fine, Douglas P.; Kuhls, Thomas L.; Slater, Leonard N.

doi:10.1097/00005792-199405000-00001

Cited by 154 publications

(27 citation statements)

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“…Rhodococcus equi, conocido previamente como Corynebacterium equi, es un bacilo grampositivo pleomórfico, intracelular facultativo, débilmente ácido-alcohol resistente, no fastidioso, cuyo nombre actual se debe a su característica cocobacilar: "rod or coccus" Causa principalmente infecciones zoonóticas 4,5 , siendo más frecuentes en animales rumiantes. Fue aislado por primera vez en 1923 por Magnusson en potros 6 ; el primer caso de infección en humanos fue descrito por Golub en 1967 7 .…”

Section: Discussionunclassified

Neumonía cavitada por Rhodococcus equi en paciente inmunocomprometido no infectado por virus de inmunodeficiencia humana: Caso clínico y revisión

et al. 2005

Rev. chil. infectol.

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Rev Chil Infect 2005; 22 (2): 155-160 CASO CLÍNICONeumonía cavitada por Rhodococcus equi en paciente inmunocomprometido no infectado por virus de inmunodeficiencia humana. Caso clínico y revisión RICARDO RABAGLIATI B., ARTURO MORALES S., RENÉ BAUDRAND B., JORGE JORQUERA A., DAVID ODDÓ B., PATRICIA GARCÍA C., M. CECILIA CARMONA P., MARCELA CISTERNAS M. y ÁLVARO HUETE G. Necrotizing pneumonia due to Rhodococcus equi in non HIV immunocompromised host. Case report and reviewRhodococcus equi, is a grampositive intracellular bacillus, that causes infection mainly in immunocompromised hosts. We report the case of a 52 years old woman, with a systemic lupus erythematosus and a progressive 10 months evolution with cough, dyspnea, mucous-purulent sputum, occasionally hemoptysis, intermittent fever, and weight loss of 10%. With partial response to antibiotic treatment, radiological evolution of thoracic scanners evidenced the development of multiple bilateral areas of consolidation, some of them nodular. Percutaneous thoracic biopsy showed characteristic histology and microbiological analysis yielded the identification of Rhodococcus equi in both bronchoalveolar lavage and pulmonary biopsy. She received prolonged bi-associated antibiotic treatment with good clinical and radiological response. This agent must be considered in the study of immunocompromised patients that present with a prolonged evolution of pneumonia.

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Section: Discussionunclassified

Neumonía cavitada por Rhodococcus equi en paciente inmunocomprometido no infectado por virus de inmunodeficiencia humana: Caso clínico y revisión

et al. 2005

Rev. chil. infectol.

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“…Su confirmación requiere la realización de pruebas moleculares como la secuenciación genética. De esta manera, podemos afirmar que, al igual que en series de casos publicadas por otros autores, el cultivo de esputo ha sido para nosotros una herramienta diagnóstica sumamente válida 1,3,6 . El LBA y los hemocultivos son también materiales úti-les para la identificación del microorganismo, y por cierto, se contaminan con menos frecuencia.…”

Section: Discussionunclassified

“…Desarrolla en los medios de cultivo dando colonias pigmentadas de un color rosa salmón característico 1 . Fue identificado por primera vez en 1923 por Magnusson en equinos 2 y el primer caso de enfermedad en humanos fue descrito por Golub en 1967 3 .…”

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Infección por Rhodococcus equi en pacientes con SIDA: Análisis retrospectivo de 13 pacientes en Argentina

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Carolis

et al. 2014

Rev. chil. infectol.

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“…equi infections have a wide range, varying from localized infection secondary to trauma to fatal systemic infection (1,5,7,16,17,23,26,28). The mortality rate for R. equi infection among immunocompetent patients is ϳ11%, compared with rates of 20 to 55% among immunocompromised patients, especially those with AIDS.…”

Section: Case Reportmentioning

confidence: 99%

Pyogenic Liver Abscess Due to Rhodococcus equi in an Immunocompetent Host

et al. 2005

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A case of pyogenic liver abscess (PLA) due to Rhodococcus equi in an immunocompetent individual was successfully treated by combining surgery and antibiotics. The R. equi-targeted antimicrobial agents erythromycin and rifampin were used only after surgical resection of the lesion and identification of the infective organism. CASE REPORTA 46-year-old man residing in the suburbs of the city of Rio de Janeiro, Brazil, was admitted to the university hospital with fever (39 to 40°C), right upper quadrant pain, nausea, vomiting, coluria, and weight loss (4 kg in 2 weeks). Abdominal ultrasound was done 2 months before hospitalization and revealed cholelithiasis. He had a history of hospitalization and blood transfusions due to gastric ulcers and melena episodes. He reported a smoking habit and sporadic alcohol ingestion. He denied having used illicit drugs and traveling to rural areas. He also denied hypertension, allergy, diabetes, tuberculosis, or other states of immunodeficiency. Clinical diagnosis revealed jaundice (1ϩ/4ϩ), paleness (2ϩ/4ϩ), tender hepatomegaly, and signs of dental infection. Abdominal ultrasonographic scanning procedures revealed the presence of two gallstones in the gall bladder and a 6-cm-diameter liver abscess with involvement of the upper and middle segments of the right lobe. There were no clinical or radiological evidences of brain, bone, or lung infection or pleural effusion. Blood samples were collected for bacteriological cultures, and empirical antimicrobial therapy was initiated with intravenous ampicillin, gentamicin, and metronidazole. In view of the clinical signs of purulent gingivitis and periodontitis, ampicillin was changed to penicillin G. Laboratory findings revealed anemia, leucocytosis (35,200 cells/l), and high levels of liver transaminases and phosphatase alkaline enzymes. The results of screening tests for human immunodeficiency virus and viral hepatitis were negative. On the fifth day after admission, there were still no significant clinical or radiological responses to antibiotics. Until day 25 of hospitalization, the patient remained afebrile with persistent abdominal pain. On day 26, the patient was found to be toxemic and feverish (38.4°C) and started vomiting green vomitus. The patient underwent percutaneous catheter drainage with ultrasound guidance, and 120 ml of chestnut-colored purulent secretion was collected from the abscess. Bacteriological cultures of the liver aspirate were negative. Penicillin G and gentamicin were changed to ceftriaxone and ampicillin. Follow-up of radiological and ultrasonographic scans of the liver indicated persistence of the abscess. Subsequent abdominal computed tomography confirmed the location of the abscess. Fifty days after admission, the patient underwent laparoscopy with drainage of the abscess and cholecystectomy. After surgical drainage and bacteriological identification of the infective organism, the patient was given R. equi-targeted antimicrobial therapy (erythromycin and rifampin) for 4 weeks. The patient was discharged fr...

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Rhodococcus equi Infections of Humans

Cited by 154 publications

References 0 publications

Neumonía cavitada por Rhodococcus equi en paciente inmunocomprometido no infectado por virus de inmunodeficiencia humana: Caso clínico y revisión

Neumonía cavitada por Rhodococcus equi en paciente inmunocomprometido no infectado por virus de inmunodeficiencia humana: Caso clínico y revisión

Infección por Rhodococcus equi en pacientes con SIDA: Análisis retrospectivo de 13 pacientes en Argentina

Pyogenic Liver Abscess Due to Rhodococcus equi in an Immunocompetent Host

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