Rhodomyrtus tomentosa (Aiton.): A review of phytochemistry, pharmacology and industrial applications research progress

Abstract

Rhodomyrtus tomentosa (Aiton) is a flowering plant native to southern and southeastern Asia.Up to date, 106 chemical constituents have been isolated and identified from R. tomentosa. Among these compounds, triterpenoids, flavonoids, phenols and meroterpenoids are the major constituents. Investigations of pharmacological activities of R. tomentosa revealed that this edible medicinal herb exhibits a wide range of therapeutic potential including antibacterial, antitumor, anti-inflammatory and antioxidant activities both in vivo and in vitro. The purpose of this review is to provide an overview of R. tomentosa studies until 2019. This article also intends to review advances in the botanical, phytochemical, pharmacological studies and industrial applications of R. tomentosa, which will provide a useful bibliography for further investigations and applications of R. tomentosa in medicines and foods.

Anti-Inflammatory and Anti-Remodelling Potential of Ethanol Extract Rhodomyrtus Tomentosa in Combination of Asthma and Coal Dust Models

“…According to the results of previous studies showed IL-1β and TNF-α can be inhibited by R. tomentosa, thereby decreasing the recruitment of eosinophils and neutrophils (27). The main compounds in R. tomentose include flavonoids, saponins, terpenoids (28). Flavonoid compounds have been shown to inhibit eosinophils by decreasing the production of IL-4 and IL-5 through the NF-κβ pathway (29).…”

Potential of karamunting (Rhodomyrtus tomentosa) fraction against kidney damage in diabetic rats

“…This condition causes a lot of misfolded insulin protein which will lead to the accumulation of misfolded insulin protein in the endoplasmic reticulum. This condition causes cell stress which leads to a cascade of oxidative stress [7,11]. Oxidative stress on pancreatic β cells will cause the activation of the inflammatory cascade, which will lead to the activation of death receptors and cause the death of pancreatic β cells [12][13].…”

Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

“…The novel skeletons of heteroterpenes, such as Rhodomyrtusials derived from terpenoid biosynthesis, have shown great potential in studies of antibacterial activities. Due to their novel and diverse structural skeletons, they are widely distributed in microorganisms, including fungi and actinomycetes, sponges, Myrtaceae, Ericaceae, Lamiaceae, and some large fungi such as Ganoderma lucidum (Matsuda and Abe, 2016;Peng and Qiu, 2018;Zhao et al, 2020).…”