Rhythms of metabolism in adipose tissue and mitochondria

Onder, Yasemin; Green, Carla B.

doi:10.1016/j.nbscr.2018.01.001

Cited by 20 publications

(13 citation statements)

References 89 publications

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“…Since the sympathetic nervous system is a stimulator of BAT [72], the higher BAT activity in SW nurses may be caused by a sympathetic stimulation. (4) Since BAT activity has a circadian rhythm [73,74], our finding may be related to a phase misalignment of a circadian cycle of BAT activity in SW compared to DT nurses. (5) Since the activity of BAT produces heat, its increased activity may be the cause of the higher peripheral skin temperature previously demonstrated in a similar sample of SW nurses [75].…”

Section: Discussionmentioning

confidence: 89%

Exosomal miR-92a Concentration in the Serum of Shift Workers

et al. 2020

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Shift work is associated with alterations in the human biological clock and metabolism. Serum exosomal miR-92a concentration was inversely correlated with brown adipose tissue activity playing a pivotal role in energy balance. In this study, miR-92a was measured in serum exosomes of 30 workers engaged in shift and daytime work. No significant metabolic alterations were shown between daytime and shift workers while a difference in serum exosomal miR-92a levels was found between the two groups. The lower levels of miR-92a in shift workers were suggestive of a higher brown adipose tissue activity compared with daytime workers. However, the possibility that other physiological and pathological processes may influence miR-92a cannot be ruled out. Our results suggest further investigations on brown adipose tissue activity and on miR-92a regulatory mechanisms, such as those related to the estrogen pathway, in shift workers.

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Section: Discussionmentioning

confidence: 89%

Exosomal miR-92a Concentration in the Serum of Shift Workers

et al. 2020

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“…Although identical clock machineries are found in most cells, the circadian expression pattern of CCGs are highly tissue-specific or even cell-type-specific [ 14 ]. Post-translational modifications also contribute to the regulation of circadian clock gene expression [ 14 , 97 ].…”

Section: Clock Componentsmentioning

confidence: 99%

Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

Man

Xia

2021

IJMS

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Every organism has an intrinsic biological rhythm that orchestrates biological processes in adjusting to daily environmental changes. Circadian rhythms are maintained by networks of molecular clocks throughout the core and peripheral tissues, including immune cells, blood vessels, and perivascular adipose tissues. Recent findings have suggested strong correlations between the circadian clock and cardiovascular diseases. Desynchronization between the circadian rhythm and body metabolism contributes to the development of cardiovascular diseases including arteriosclerosis and thrombosis. Circadian rhythms are involved in controlling inflammatory processes and metabolisms, which can influence the pathology of arteriosclerosis and thrombosis. Circadian clock genes are critical in maintaining the robust relationship between diurnal variation and the cardiovascular system. The circadian machinery in the vascular system may be a novel therapeutic target for the prevention and treatment of cardiovascular diseases. The research on circadian rhythms in cardiovascular diseases is still progressing. In this review, we briefly summarize recent studies on circadian rhythms and cardiovascular homeostasis, focusing on the circadian control of inflammatory processes and metabolisms. Based on the recent findings, we discuss the potential target molecules for future therapeutic strategies against cardiovascular diseases by targeting the circadian clock.

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“…In human adipose tissue, the expression of BMAL1 and CLOCK peaks in the late evening, while the expression of PERs, CRY2, and REV-ERBα peak around late morning [ 85 ]. In addition, post-translational modifications also contribute to the regulation of the circadian clock [ 70 , 94 ].…”

Section: Circadian Rhythm In Adipose Tissuementioning

confidence: 99%

Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases

Man¹,

Xia²,

Li³

2020

Antioxidants

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Obesity is a major risk factor for most metabolic and cardiovascular disorders. Adipose tissue is an important endocrine organ that modulates metabolic and cardiovascular health by secreting signaling molecules. Oxidative stress is a common mechanism associated with metabolic and cardiovascular complications including obesity, type 2 diabetes, and hypertension. Oxidative stress can cause adipose tissue dysfunction. Accumulating data from both humans and experimental animal models suggest that adipose tissue function and oxidative stress have an innate connection with the intrinsic biological clock. Circadian clock orchestrates biological processes in adjusting to daily environmental changes according to internal or external cues. Recent studies have identified the genes and molecular pathways exhibiting circadian expression patterns in adipose tissue. Disruption of the circadian rhythmicity has been suggested to augment oxidative stress and aberrate adipose tissue function and metabolism. Therefore, circadian machinery in the adipose tissue may be a novel therapeutic target for the prevention and treatment of metabolic and cardiovascular diseases. In this review, we summarize recent findings on circadian rhythm and oxidative stress in adipose tissue, dissect the key components that play a role in regulating the clock rhythm, oxidative stress and adipose tissue function, and discuss the potential use of antioxidant treatment on metabolic and cardiovascular diseases by targeting the adipose clock.

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Rhythms of metabolism in adipose tissue and mitochondria

Cited by 20 publications

References 89 publications

Exosomal miR-92a Concentration in the Serum of Shift Workers

Exosomal miR-92a Concentration in the Serum of Shift Workers

Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases

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