“…This can be a serious complication resulting in leakage of food, fluid or saliva around the prosthesis into the airway, reported in 7%–42% of patients with TEP 8,9 . There is controversy regarding the factors that could influence the development of this type of leakage 8,10–13 . Apart from individual predisposition, various factors have been discussed in the literature including local inflammatory responses in the region of the fistula, atrophy of the tracheoesophageal wall as a late effect of preoperative or postoperative radiotherapy or chemoradiotherapy, the VP diameter or weight, the timing of VP puncture, the VP insertion, the patient's nutritional status, the patient's length of follow‐up, a continuing history of tobacco exposure, the gastroesophageal reflux, a microbial colonisation the gastroesophageal reflux, a microbial colonisation, an extensive laryngopharyngeal resection and postoperative stricture, or the presence of conditions that have previously been proposed in the literature as predisposing factors that could affect the duration of VP (e.g., diabetes, hypertension, lymph node metastases, thyroid dysfunction, or tumour recurrence).…”