Riboflavin injection into the corneal channel for combined collagen crosslinking and intrastromal corneal ring segment implantation

Abstract

No author has a financial or proprietary interest in any material or method mentioned.

Long-term outcomes of intrastromal corneal ring segment implantation for post-LASIK ectasia

“…Currently, ICRS is mostly used in patients with keratoconus [2] and is becoming a popular alternative for the treatment of post-LASIK ectasia. ICRS can be used alone or in combination with other techniques, such as corneal collagen cross-linking (CXL) to improve vision [3][4][5][6].…”

Corneal Cross-linking in Combination with Intracorneal Ring Segments

“…7 Kılıç et al proposed a technique for riboflavin application without epithelial removal. 26 In this technique, patients underwent combined CXL and ICRS and simultaneous transepithelial CXL with riboflavin injection into the corneal channel (Figs 2 and 3). …”

Corneal Collagen Crosslinking with Riboflavin and Ultraviolet - A Irradiation in the Management of Progressive Ectatic Corneal Disorders. Review Article

“…This may be related to the unpredictable refractive outcomes when excimer ablation is performed on cross-linked tissues. However, performing both procedures concurrently on the same day may cause an irregular healing process with the formation of persistent stromal haze, probably related to keratocyte activation, which permanently affects visual performance 95,96 .…”

“…Moreover, it was reported that after one or both ring explantations, the refractive effects may be stable or reversible while the topographic changes seem to be maintained [96][97][98][99] . Therefore, while collagen crosslinking can be performed before, in conjunction with, or after ICRS implantation, the ideal method for combining these two treatments is still undefined.…”