Ribosome biogenesis and resistance training volume in human skeletal muscle

Solsona, Robert; Sanchez, Anthony M. J.

doi:10.1113/jp279490

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…[257]. An important factor implicated in the mitigated response to resistance training is ribosome content [59,61,62,258]. For example, blunted ribosome biogenesis was observed in the elderly with a lower hypertrophic response [59,[259][260][261].…”

Section: Impact Of Exercise Training and Practical Recommendationsmentioning

confidence: 99%

“…However, while exercise intensity does not appear to be a key factor in adaptations to resistance training in the elderly, manipulating training volume appears most relevant. With a contralateral protocol, a study highlighted a dose-dependent relationship between muscle adaptations and training volume [62,258]. Moderate training volume induced more pronounced gains in muscle strength and mass, as well as a greater ribosome biogenesis and type II fiber transition compared to low training volume [62,258].…”

Section: Impact Of Exercise Training and Practical Recommendationsmentioning

confidence: 99%

“…With a contralateral protocol, a study highlighted a dose-dependent relationship between muscle adaptations and training volume [62,258]. Moderate training volume induced more pronounced gains in muscle strength and mass, as well as a greater ribosome biogenesis and type II fiber transition compared to low training volume [62,258]. A previous study underlined that resistance exercise conducted at low-load and high-volume was more effective than highload and low-volume to stimulate myofibrillar protein synthesis in young men [212].…”

Section: Impact Of Exercise Training and Practical Recommendationsmentioning

confidence: 99%

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Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training

Solsona

Pavlin

Bernardi

et al. 2021

IJMS

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The regulation of skeletal muscle mass and organelle homeostasis is dependent on the capacity of cells to produce proteins and to recycle cytosolic portions. In this investigation, the mechanisms involved in skeletal muscle mass regulation—especially those associated with proteosynthesis and with the production of new organelles—are presented. Thus, the critical roles of mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway and its regulators are reviewed. In addition, the importance of ribosome biogenesis, satellite cells involvement, myonuclear accretion, and some major epigenetic modifications related to protein synthesis are discussed. Furthermore, several studies conducted on the topic of exercise training have recognized the central role of both endurance and resistance exercise to reorganize sarcomeric proteins and to improve the capacity of cells to build efficient organelles. The molecular mechanisms underlying these adaptations to exercise training are presented throughout this review and practical recommendations for exercise prescription are provided. A better understanding of the aforementioned cellular pathways is essential for both healthy and sick people to avoid inefficient prescriptions and to improve muscle function with emergent strategies (e.g., hypoxic training). Finally, current limitations in the literature and further perspectives, notably on epigenetic mechanisms, are provided to encourage additional investigations on this topic.

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Section: Impact Of Exercise Training and Practical Recommendationsmentioning

confidence: 99%

Section: Impact Of Exercise Training and Practical Recommendationsmentioning

confidence: 99%

Section: Impact Of Exercise Training and Practical Recommendationsmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training

Solsona

Pavlin

Bernardi

et al. 2021

IJMS

Self Cite

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“…Fatigue promotes a decrease in the total volume performed (i. e., repetitions number) by everyone engaged in the resistance training [2,3]. The lower amount performed in each training session could harm the muscular adaptation targeted by the specific training program (i. e., the positive adaptations would be lower than expected) [4,5]. Hence, strategies to keep or improve the training volume are targeted by resistance training programs.…”

Section: Introductionmentioning

confidence: 99%

Caffeine Supplementation or Carbohydrate Mouth Rinse Improves Performance

Pereira

Azevedo

Azevedo³

et al. 2020

Int J Sports Med

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Training volume is one of the critical variables required to promote resistance training benefits (e. g., hypertrophy, muscular strength). Thus, strategies to improve training volume are required. We tested the hypothesis that there is an increase in performance and reduction in the rate of perceived exertion in strength training with caffeine supplementation, carbohydrate mouth rinse, and a synergistic effect of caffeine supplementation plus carbohydrate mouth rinse. We recruited 29 physically active women: 24±4 years, 60.0±7.9 kg, 161.0±6.0 cm. This study was a double-blind, randomized, placebo-controlled, and crossover one. The subjects performed all sessions of strength training under different conditions: caffeine (6.5 mg·kg−1 body mass); carbohydrate (6 g of maltodextrin rinsed for 10 s); caffeine plus carbohydrate; or placebo. We applied the ANOVA for repeated measures through the null-hypothesis statistical test, and the Bayes factors analyses approach. The subjects showed significant improvement in the total repetitions (P<0.01; BF10 ~99%) for both lower and upper limb exercises in all conditions compared to placebo without difference among interventions. The rate of perceived exertion (P>0.05) did not differ among interventions. However, BF10 analyses showed a higher probability of lower RPE for CAF intervention. We conclude that either caffeine supplementation or carbohydrate mouth rinse can improve performance in resistance training. There is no additional effect of caffeine plus carbohydrate.

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“…The process of tumor initiation and progression is closely intertwined with the contribution of the tumor microenvironment (TME) (7,12). The TME constitutes a complex biological system surrounding tumor cells, including non-tumor cells such as immune cells, fibroblasts, endothelial cells, extracellular matrix (ECM), blood vessels, lymphatic vessels, signaling molecules, and metabolites, among others (7,12). Among these components, lysosomes play an indispensable role in regulating immune functions, antigen presentation, and immune evasion (13).…”

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confidence: 99%

The significance of targeting lysosomes in cancer immunotherapy

Xu,

Shao,

Zhang

2024

Front. Immunol.

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Lysosomes are intracellular digestive organelles that participate in various physiological and pathological processes, including the regulation of immune checkpoint molecules, immune cell function in the tumor microenvironment, antigen presentation, metabolism, and autophagy. Abnormalities or dysfunction of lysosomes are associated with the occurrence, development, and drug resistance of tumors. Lysosomes play a crucial role and have potential applications in tumor immunotherapy. Targeting lysosomes or harnessing their properties is an effective strategy for tumor immunotherapy. However, the mechanisms and approaches related to lysosomes in tumor immunotherapy are not fully understood at present, and further basic and clinical research is needed to provide better treatment options for cancer patients. This review focuses on the research progress related to lysosomes and tumor immunotherapy in these

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Ribosome biogenesis and resistance training volume in human skeletal muscle

Cited by 7 publications

References 6 publications

Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training

Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training

Caffeine Supplementation or Carbohydrate Mouth Rinse Improves Performance

The significance of targeting lysosomes in cancer immunotherapy

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