Rice bran extract supplement improves sleep efficiency and sleep onset in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study

Um, Min Young; Yang, Hyejin; Han, Jae Hyeon; Kim, Jin Young; Kang, Seung Wan; Yoon, Minseok; Kwon, Sang-Oh; Cho, Suengmok

doi:10.1038/s41598-019-48743-8

Cited by 14 publications

(7 citation statements)

References 41 publications

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“…The RBS (Lot No. SD-RB-002) standardized with 0.45% γ-oryzanol was obtained from S&D Co., Ltd. (Cheongju, Korea) as previously described [ 19 20 21 ]. Briefly, rice bran ( O. sativa L.) was extracted in an ethanol/water solution at 40°C for 8 h. The ethanol extract was filtered, concentrated, and spray-dried for storage.…”

Section: Methodsmentioning

confidence: 99%

Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats

et al. 2020

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BACKGROUD/OBJECTIVES: Hepatic steatosis is the most common liver disorder, particularly in postmenopausal women. This study investigated the protective effects of standardized rice bran extract (RBS) on ovariectomized (OVX)-induced hepatic steatosis in rats. MATERIALS/METHODS: HepG2 cells were incubated with 200 µM oleic acid to induce lipid accumulation with or without RBS and γ-oryzanol. OVX rats were separated into three groups and fed a normal diet (ND) or the ND containing 17β-estradiol (E2; 10 µg/kg) and RBS (500 mg/kg) for 16 weeks. RESULTS: RBS supplementation improved serum triglyceride and free fatty acid levels in OVX rats. Histological analysis showed that RBS significantly attenuated hepatic fat accumulation and decreased hepatic lipid, total cholesterol, and triglyceride levels. Additionally, RBS suppressed the estrogen deficiency-induced upregulation of lipogenic genes, such as sterol regulatory element-binding protein 1 (SREBP1), acetyl-CoA carboxylase 1, fatty acid synthase, glycerol-3-phosphate acyltransferase, and stearoyl-CoA desaturase 1. CONCLUSIONS: RBS and γ-oryzanol effectively reduced lipid accumulation in a HepG2 cell hepatic steatosis model. RBS improves OVX-induced hepatic steatosis by regulating the SREBP1-mediated activation of lipogenic genes, suggesting the benefits of RBS in preventing fatty liver in postmenopausal women.

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Section: Methodsmentioning

confidence: 99%

Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats

et al. 2020

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“…Nevertheless, once anxiety symptoms occur from sleep deprivation, this kind of vicious sleep disruption will hamper the therapeutic efficacy in anxiety patients. Therefore, proper and safe supplementary nutrients are needed for anxiety relief while improving sleep patterns in anxious patients [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo

Lee

et al. 2021

BMC Complement Med Ther

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Background Sleep disruption is a major public health issue and may increase the risk of mortality by ten-folds if an individual is sleeping less than 6 h per night. Sleep has changed dramatically during to the COVID-19 pandemic because COVID symptoms can lead to psychological distress including anxiety. Hericium erinaceus mycelium has been widely investigated in both the in vivo studies and clinical trials for its neuroprotective functions because the mycelium contains hericenones and erinacines, which synthesize the nerve growth factor and brain-derived neurotrophic factor (BDNF). Recent in vivo reports have shown showed that erinacine A-enriched Hericium erinaceus mycelium can modulate BDNF/TrkB/PI3K/Akt/GSK-3β pathways to induce an antidepressant-like effect. A large body of evidence indicates that erinacine can pass the blood-brain barrier and suggests its neuroprotective function in both peripheral and central nervous systems. Thus, Hericium erinaceus mycelium may be a dual-function supplement for sleep disruption improvement while sustaining anxiolytic effects. Method To simulate the condition of sleep disruption, the mice were subjected to the tail suspension test (TST) for 15 min every day during the same period for nine consecutive days. Two different doses (75 and 150 mg/kg) of Hericium erinaceus mycelium were administered orally 20 min prior to the TSTs before entering the light period of 12:12 h L:D cycle. All sleep-wake recording was recorded for 24 h using electroencephalogram and electromyogram. The elevated-plus-maze and open-field tests were conducted to record the behavior activities. Results Consecutive TSTs prior to the light period could cause significant sleep disturbance and anxiety behavior in the elevated-plus-maze experiments. Results showed that administration with Hericium erinaceus mycelium at 150 mg/kg ameliorated the rodent anxiety (p < 0.05) and reversed the TST-induced NREM sleep disturbance in the dark period. Conclusion This is the first in vivo study suggesting that Hericium erinaceus mycelium has a dual potential role for anxiety relief through improving sleep disruptions.

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“…Tart cherry juice consumption for 7 days has shown to significantly increase total sleep time and sleep efficiency ( 40 ). In another study, significant improvement in sleep efficiency was reported when a rice bran extract was supplemented for 14 days at 1000 mg/day ( 41 ). These studies justify our protocol involving 7 days’ supplementation to investigate the influence of BCO-5 on sleep.…”

Section: Discussionmentioning

confidence: 99%

Exploring the short-term influence of a proprietary oil extract of black cumin (Nigella sativa) on non-restorative sleep: a randomized, double-blinded, placebo-controlled actigraphy study

Mohan,

Prabhakaran

et al. 2024

Front. Nutr.

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BackgroundNigella sativa (black cumin, or black seed) is popularly known as the seed of blessings in the Arab system of medicine. Though not widely recommended for sleep, a unique proprietary black cumin extract (BlaQmax®/ThymoDream™; BCO-5) has been shown to be helpful in the management of stress and sleep issues.MethodsThis randomized, double-blind, placebo-controlled trial aimed to investigate the efficacy of BCO-5 on the sleep quality of volunteers characterized with a self-reported non-restorative sleep disorder. Healthy male and female participants (n = 70), aged 18-65 years (BMI 22-28 Kg/m2) were randomized to either placebo or BCO-5 (n = 35/group). Both interventions were supplemented at 200 mg/day for seven days. Actigraphy and a validated restorative sleep questionnaire (RSQ-W) were used to monitor the influence of BCO-5 on sleep.ResultsCompared to placebo, BCO-5 significantly improved sleep quality, as evidenced by both intra-group and inter-group analyses of the actigraphy data. The relative improvements observed were sleep efficiency (7.8%, p < 0.001), total sleep time (19.1%, p < 0.001), sleep onset latency (35.4%; p < 0.001), and wake-after-sleep-onset (22.5%; p < 0.001) compared with placebo. BCO-5 also improved sleep by 75.3% compared to baseline (p < 0.001) and by 68.9% compared to placebo (p < 0.001), when monitored by RSQ-W. BCO-5 was well-tolerated with no reports of side effects or toxicity.ConclusionBCO-5 significantly improved non-restorative sleep in seven days, indicating its potential role as a natural sleep aid.

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Rice bran extract supplement improves sleep efficiency and sleep onset in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study

Cited by 14 publications

References 41 publications

Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats

Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats

Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo

Exploring the short-term influence of a proprietary oil extract of black cumin (Nigella sativa) on non-restorative sleep: a randomized, double-blinded, placebo-controlled actigraphy study

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