Land use and land cover (LULC) form a baseline thematic map for monitoring, resource management, and planning activities and facilitate the development of strategies to balance conservation, conflicting uses, and development pressures. In this study, changes in LULC in North Sumatra, Indonesia, are simulated and predicted using an artificial-neural-network-based cellular automaton (ANN-CA) model. Five criteria (altitude, slope, aspect, distance from the road, and soil type) are used as exploratory data in the learning process of the ANN-CA model to determine their impacts on LULC changes between 1990 and 2000; among the criteria, altitude and distance from the road have strong impacts. Comparison between the predicted and the real LULC maps for 2010 illustrates high agreement, with a Kappa index of 0.83 and a percentage of correctness of 87.28%. Then, the ANN-CA model is applied to predict LULC changes in 2050 and 2070. The LULC predictions for 2050 and 2070 demonstrate high increases in plantation area of more than 4%. Meanwhile, forest and crop area are projected to decrease by approximately 1.2% and 1.6%, respectively, by 2050. By 2070, forest and crop areas will decrease by 1.2% and 1.7%, respectively, indicating human influences on LULC changes from forest and cropland to plantations. This study illustrates that the simulation of LULC changes using the ANN-CA model can produce reliable predictions for future LULC.Simulation of LULC changes provides the baseline scenario for use when predicting future scenarios and patterns in future development. Simulation of LULC changes can indicate anthropogenic impact, identify land use problems, such as the degradation and deforestation, and be used in land use planning [2]. Land use changes have been important aspects for regional and urban planning for centuries. Most of the research predicts land use changes using the independent variable with the highest correlation to those changes. Verburg et al. [3] illustrated that the multiscale characteristics of land use systems require new techniques to quantify neighborhood effects. Furthermore, Verburg et al.[3] also explicitly dealt with temporal dynamics and achieved a higher level of integration among disciplinary approaches and between models studying urban and rural land use changes. Multivariate spatial models [4], Markov analysis [5], cellular automata (CA) [3,6-9], neural-network-based CA [2], empirical-statistical models [10,11], optimization models [12], and agent-based models [13,14] have all been used in the simulation of land use change. More details on each method can be found in [15].The CA is a common method for simulating the LULC change spatial evolution by estimating the state of a pixel according to its initial state, surrounding neighborhood effects and transition rules. A CA model can generate rich patterns and effectively represent nonlinear spatially stochastic LULC change processes [16,17]. The applications of CA models have been growing in urban development studies, with strong capabilities for si...