2018
DOI: 10.1186/s13068-018-1132-x
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Rich biotin content in lignocellulose biomass plays the key role in determining cellulosic glutamic acid accumulation by Corynebacterium glutamicum

Abstract: BackgroundLignocellulose is one of the most promising alternative feedstocks for glutamic acid production as commodity building block chemical, but the efforts by the dominant industrial fermentation strain Corynebacterium glutamicum failed for accumulating glutamic acid using lignocellulose feedstock.ResultsWe identified the existence of surprisingly high biotin concentration in corn stover hydrolysate as the determining factor for the failure of glutamic acid accumulation by Corynebacterium glutamicum. Under… Show more

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Cited by 16 publications
(34 citation statements)
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“…Lignocellulose biomass is the most promising alternative feedstock for the production of glutamic acid that can be used as building block chemical [1]. However, no essential glutamic acid had been successfully produced from lignocellulose biomass until recently the rich biotin content in lignocellulose biomass was identified [2]. The rich biotin in lignocellulose biomass maintains stability during the biorefinery processing and creates an excessive condition for glutamic acid secretion [2].…”
Section: Introductionmentioning
confidence: 99%
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“…Lignocellulose biomass is the most promising alternative feedstock for the production of glutamic acid that can be used as building block chemical [1]. However, no essential glutamic acid had been successfully produced from lignocellulose biomass until recently the rich biotin content in lignocellulose biomass was identified [2]. The rich biotin in lignocellulose biomass maintains stability during the biorefinery processing and creates an excessive condition for glutamic acid secretion [2].…”
Section: Introductionmentioning
confidence: 99%
“…However, no essential glutamic acid had been successfully produced from lignocellulose biomass until recently the rich biotin content in lignocellulose biomass was identified [2]. The rich biotin in lignocellulose biomass maintains stability during the biorefinery processing and creates an excessive condition for glutamic acid secretion [2]. Excessive biotin resulted in reduced carbon flux for glutamic acid biosynthesis [3] but strengthened cell wall barrier for glutamic acid secretion [2, 4, 5].…”
Section: Introductionmentioning
confidence: 99%
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“…A kerosene fungus Amorphotheca resinae ZN1 was isolated for complete removal of inhibitors from acid pretreated lignocellulose biomass in our previous studies (Zhang et al 2010). The biodetoxified biomass has been applied to produce ethanol (Liu et al 2018), chiral lactic acid (Qiu et al 2017(Qiu et al , 2018, glutamic acid (Wen et al 2018), citric acid (Zhou et al 2017), and gluconic acid (Zhang et al 2016).…”
Section: Introductionmentioning
confidence: 99%