Rickets and soil strontium.

Özgür, Servet; Sümer, Haldun; Koçoğlu, Gülay

doi:10.1136/adc.75.6.524

Cited by 83 publications

(26 citation statements)

References 11 publications

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“…12 There is also a report that strontium in the soil can have a similar effect. 36 In contrast to an earlier report from Tanzania, 37 Thacher and colleagues 32 found no differences in the source of water between patients and controls living around Jos, but they did not report fluoride concentrations. There may be other sociocultural differences between our population and the South African one.…”

Section: Discussionmentioning

confidence: 72%

Radiological and biochemical resolution of nutritional rickets with calcium * COMMENTARY

Oginni

Sharp²,

Badru³

et al. 2003

Archives of Disease in Childhood

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Aims: To determine the response to oral calcium in Nigerian children with rickets. Methods: In a teaching hospital in Western Nigeria, 26 children (13 boys, 13 girls, aged 2-5 years) with confirmed rickets received calcium lactate (2.7 g/day). Results: Within one month of treatment leg pain was relieved and the children were more active. The mean x ray score improved from 3.3 at baseline to 1.7 at three months and 0.9 at six months (arbitrary scoring system, 0-6). Twelve cases were healed radiologically after six months, 11 others improved considerably, two showed no significant improvement, and a non-compliant patient was worse. There was progressive reversal of biochemical features. Median plasma alkaline phosphatase fell from 519 (range 178-1078) to 283 (209-443) IU/l (p = 0.04) in four months, while mean 1,25-dihydroxyvitamin D fell from 473 (251-1057) to 281 (155-481) pmol/l (p = 0.04), and mean plasma calcium increased from 2.26 (1.63-2.54) to 2.37 (2.06-2.54) mmol/l (p = 0.13). Parathyroid hormone fell from 5.3 (0.4-21.5) to 1.7 (0.45-7.4) pmol/l. Type I collagen carboxy terminal cross linked telopeptide was very high at baseline (20 (7.2-103) to 14 (11-24) µg/l) (p = 0.03) and fell promptly to normal. Conclusion: Calcium supplementation alone effected healing of rickets in most of these Nigerian children and may provide sufficient treatment in this environment.

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Section: Discussionmentioning

confidence: 72%

Radiological and biochemical resolution of nutritional rickets with calcium * COMMENTARY

Oginni

Sharp²,

Badru³

et al. 2003

Archives of Disease in Childhood

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“…Data in literature indicate that a high dietary intake of strontium may disturb bone mineralization and induce bone abnormalities [2][3][4][5][6][7][8][9]. In rats with intact renal function, the development of rickets was induced after adding the element to the animals' drinking water at a concentration of 4 g/L (± 400 mg/kg/day, as extrapolated from the weight and daily fluid intake of adult rats) [3,10].…”

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confidence: 99%

Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats

Oste

Bervoets

Behets

et al. 2005

Kidney International

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“…Ein gehäuftes Auftreten von Rachitis wurde weiters bei Kindern beobachtet, welche Trinkwasser mit hohen Strontiumkonzentrationen konsumierten und gleichzeitig einem alimentären Kalziummangel ausgesetzt waren [18]. Demgegenüber konnte in einer kürz-lich publizierten Langzeitstudie an gesunden Makaken, deren Knochenstoffwechsel demjenigen der humanen Spezies sehr ähnlich ist, auch in höherer Dosierung kein nachteiliger Effekt auf die Mineralisation und Parameter der Kristallstruktur des Hydroxylapatites nachgewiesen werden [19].…”

Section: Intestinale Aufnahme Von Strontium Und Strontiumranelatunclassified

Strontium ranelate: a novel concept for the treatment of osteoporosis

Dimai

2005

Wien Klin Wochenschr

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The di-strontium salt strontium ranelate, a novel orally active agent consisting of two atoms of stable strontium and the organic moiety ranelic acid, has been developed for the treatment of osteoporosis. It has been shown to enhance osteoblastic cell replication and increase collagen synthesis while decreasing pre-osteoclast differentiation and bone-resorbing activity of mature osteoclasts in vitro. Studies performed in healthy animals have shown that strontium ranelate not only increases bone mass at various skeletal sites but also improves mechanical properties of femoral, humeral and vertebral bones. In estrogen-deficient animals, strontium ranelate effectively inhibits increased bone resorption while maintaining bone formation. Similar results have been obtained from studies in hind limb-immobilized animals. Strontium ranelate has been investigated in a large phase III program which includes two extensive multinational, randomized, double-blind, placebo-controlled clinical trials for the treatment of severe postmenopausal osteoporosis. Before inclusion in these two studies, patients were subjected to a run-in study in order to initiate normalization of their calcium and vitamin D status. The SOTI study, aimed at assessing strontium ranelate's effect on the risk of vertebral fractures, revealed a significant reduction in the risk of new vertebral fractures in the group treated with strontium ranelate. The TROPOS study, which aimed at evaluating the effect of strontium ranelate on nonvertebral fractures, showed a significant reduction in the risk of new nonvertebral fractures and also, in a high-risk subgroup, a significant reduction in the risk of hip fractures. In both studies, the reduction in fracture risk was accompanied by an increase in bone mineral density. The increase remained significant also after correction of the bone mineral density for the higher atomic mass of strontium compared to calcium. Furthermore, an increase in serum levels of a bone formation marker and a decrease in serum levels of a bone resorption marker were observed. The spectrum of side effects comprised mild diarrhea, particularly within the first weeks of treatment, and also a slightly increased risk of venous thromboembolic events. Strontium ranelate thus appears to be a new, effective treatment to prevent fractures in postmenopausal osteoporosis with a novel mechanism of action. It can be expected for the near future that strontium ranelate will also be evaluated for other types of osteoporosis, such as male osteoporosis.

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Rickets and soil strontium.

Cited by 83 publications

References 11 publications

Radiological and biochemical resolution of nutritional rickets with calcium * COMMENTARY

Radiological and biochemical resolution of nutritional rickets with calcium * COMMENTARY

Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats

Strontium ranelate: a novel concept for the treatment of osteoporosis

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