In this paper the influence of a Ride-Control System (RCS) on the Response Amplitude Operator (RAO) of a full-scale high-speed catamaran was investigated using sea trials data. A T-foil and stern tabs were installed on a Wave-Piercing Catamaran (Incat Tasmania Hull 061) to improve ship motions and passenger comfort. More than 40 total effective hours of sea trials were conducted by the US Navy in 2004, encountering sea states 4–5 in the Atlantic Ocean near the United Kingdom. The reduction in Motion Sickness Incidence (MSI) was estimated in order to examine the effectiveness of the RCS in improving passenger comfort. By comparing the case of active RCS (T-foil plus stern tabs) with the case of active stern tabs only, it was found that the T-foil plays a vital role in the passenger comfort enhancement. Based on ISO recommended MSI calculation of a 2-h seaway, the percentage reduction in MSI was estimated, and hence the effectiveness of the T-foil deployment, along with the influence of speeds, headings, location on board and encountered wave height were analysed. A notable improvement in passenger comfort was observed in the real world bow quartering sea by deploying the RCS. An MSI reduction of 21% in high speeds (30–35 knots, [Formula: see text] 0.6) was observed, which was almost twice the MSI reduction (11%) in low speeds (15–20 knots, [Formula: see text] 0.3). However, in terms of MSI percentage reduction, the ability of T-foil in vessel motion control in oblique seas was found to be limited compared to the results in head seas.