Rifabutin-loaded Floating Gellan Gum Beads: Effect of Calcium and Polymer Concentration on Incorporation Efficiency and Drug Release

Verma, Anurag; Pandit, J. K.

doi:10.4314/tjpr.v10i1.66542

Cited by 16 publications

(10 citation statements)

References 15 publications

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“…8). Verma et al [14] investigated the effect of gellan gum concentration (1, 3, 5 %, w/v) on the quality of rifabutin-loaded floating gellan gum beads and obtained similar results about the in vitro release of drug. In this experiment, beads were prepared by dropwise adding of the gellan gum solution into the cross-linking solution through a needle.…”

Section: The Effect Of Calcium Chloride Concentrationmentioning

confidence: 89%

“…Gellan gum was dispersed in deionized water and then heated to 90°C with agitation for about 5 min until total dissolution. Core material BSA (50 % of the dry mass of gellan gum) was then dispersed in the gellan gum solution at around 40°C with continuous stirring until a uniform dispersion was obtained [14]. Chitosan solution was prepared by dissolving it with stirring in 3 % (v/v) acetic acid and mixed with calcium chloride.…”

Section: Preparation Of the Chitosan-calcium-gellan Gum Beadsmentioning

confidence: 99%

“…In aqueous solution, the gelation of gellan was accompanied by a two-step process, namely formation of double helices from random coil chains and an aggregation of pairs of double helices to form a three-dimensional network [14]. However, the carboxyl side chains of gellan gum molecules repelled each other due to electrostatic interactions, which impeded the aggregation of double helices.…”

Section: The Effect Of Calcium Chloride Concentrationmentioning

confidence: 99%

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Preparation and evaluation of chitosan-calcium-gellan gum beads for controlled release of protein

Yang

Xia

Tan

et al. 2013

Eur Food Res Technol

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The bead system composed of chitosan and calcium-gellan gum was prepared through a combination of ionotropic gelation and polyelectrolyte complexation for oral protein delivery. The characteristics of beads were investigated by scanning electron microscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, release studies, and swelling measurements. It was found that chitosan endowed the calcium-gellan gum beads a dense surface and the crystal structure of polymers was disrupted after being combined together. The encapsulation efficiency of protein was in the range of 65-85 %. Higher gellan gum concentration combined with vacuum dryness significantly retarded protein fast release at pH 1.2 and achieved sustained release at pH 6.8, whereas providing efficient release at pH 7.4. The protein release was mainly attributed to Fickian diffusion mechanism in the process of swelling. The chitosan-calcium-gellan gum beads have the potential to act as a new carrier for controlled release of protein-based functional ingredients.

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Section: The Effect Of Calcium Chloride Concentrationmentioning

confidence: 89%

Section: Preparation Of the Chitosan-calcium-gellan Gum Beadsmentioning

confidence: 99%

Section: The Effect Of Calcium Chloride Concentrationmentioning

confidence: 99%

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Preparation and evaluation of chitosan-calcium-gellan gum beads for controlled release of protein

Yang

Xia

Tan

et al. 2013

Eur Food Res Technol

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“…Its good biological properties, along with its bioadhesive nature, have drawn enormous attention from nanotechnologists for several bionano applications, such as microparticles, nanoparticles, hydrogels, stabilizing agents, thickeners, emulsifiers, and coating agents [ 192 ]. Gellan gum beads in the form of micro- and nanoparticles have been widely used for drug delivery, and their effectiveness has been studied both in vitro and in vivo [ 193 , 194 , 195 ]. Similarly, the negative charge of the polymer facilitates the binding of heavy metals, and hence it has been successfully used as a sorbent [ 196 ].…”

Section: Polysaccharidesmentioning

confidence: 99%

Smart Carriers and Nanohealers: A Nanomedical Insight on Natural Polymers

et al. 2017

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Biodegradable polymers are popularly being used in an increasing number of fields in the past few decades. The popularity and favorability of these materials are due to their remarkable properties, enabling a wide range of applications and market requirements to be met. Polymer biodegradable systems are a promising arena of research for targeted and site-specific controlled drug delivery, for developing artificial limbs, 3D porous scaffolds for cellular regeneration or tissue engineering and biosensing applications. Several natural polymers have been identified, blended, functionalized and applied for designing nanoscaffolds and drug carriers as a prerequisite for enumerable bionano technological applications. Apart from these, natural polymers have been well studied and are widely used in material science and industrial fields. The present review explains the prominent features of commonly used natural polymers (polysaccharides and proteins) in various nanomedical applications and reveals the current status of the polymer research in bionanotechnology and science sectors.

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“…They suggested that the reason for this phenomenon is that gellan solutions formed rigid gels at acidic pH which brought about marked release retardation on which increased polymer concentration did not show significant effect. In another study, Verma and Pandit found insignificant effect of gellan concentration on drug release which they associated with inadequate availability of cross-linking agents for the higher polymer concentration 32 . This reason could also apply in our study where fixed amount of crosslinking agent (CaCO 3 ) was used at different levels of SA.…”

Section: Fig4: Effect Of Caco 3 Concentration On Release Of Salbutammentioning

confidence: 99%

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2016

IJPSR

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Salbutamol is a selective β2-adreno-receptor stimulant and is given four times daily in a dose of 2.4 mg orally to maintain therapeutic blood level. It is known to be absorbed in proximal parts of the small intestine. Prolonging gastric residence time is, therefore, beneficial to improve its bioavailability. Hence, seven in situ gelling liquid formulations were prepared using sodium alginate (SA) as gel forming agent and HPMC as viscosity enhancer. CaCO 3 was incorporated as crosslinker and floating agent. Gelling capacity was evaluated based on a graded response which indicates rapidity of gelation and time taken by the gel to dissolve. All the formulations showed instant gelation but with regard to integrity, all formulations except the one with lowest SA level formed stiff gels maintaining integrity for at least 12 hr. With respect to floating behavior, all formulations except the one with the lowest SA level floated for more than 12 hr irrespective of their composition. Most of the formulations took less than 1 min to float but those with the lowest SA and CaCO 3 levels floated after about 2 min. Drug release study revealed release retarding behavior of the formulations and noticeable burst release. This effect was reduced at higher concentration of SA and CaCO 3 . Release retarding effect of SA was only marginal at higher concentrations. CaCO 3 showed a similar effect but at higher levels insignificant change in release was observed. The drug release process, in all cases, best fits first order kinetics (R2 ranged between 0.932 and 0.991) and in most cases it seemed to occur by non-Fickian mechanisms (0.43 < n < 0.85). In formulations with lowest levels of SA and CaCO 3 , quasi-Fickian diffusion (n < 0.43) process prevailed. The study demonstrated that the in situ gelling formulations can be used as novel formulations with sustained drug release, improved bioavailability and thereby improve patient compliance.

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Rifabutin-loaded Floating Gellan Gum Beads: Effect of Calcium and Polymer Concentration on Incorporation Efficiency and Drug Release

Cited by 16 publications

References 15 publications

Preparation and evaluation of chitosan-calcium-gellan gum beads for controlled release of protein

Preparation and evaluation of chitosan-calcium-gellan gum beads for controlled release of protein

Smart Carriers and Nanohealers: A Nanomedical Insight on Natural Polymers

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