Rifampicin and Thrombocytopenia

Rifampin Augmentation in Hardware Infections: A Case Report of Thrombocytopenia

“…Although rifampin has been implicated as a cause of thrombocytopenia, this adverse effect has been described primarily in the setting of complex TB regimens. [3][4][5][6][7] While early reports described hematologic toxicities with ≥600 mg/ day, it should be noted that toxicities have also occurred with lower intermittent dosing regimens. [3][4][5][6][7] Therefore, the 300-to 450-mg twice-daily rifampin regimens recommended for PJIs may place patients at increased risk of developing hematologic toxicities.…”

“…[3][4][5][6][7] While early reports described hematologic toxicities with ≥600 mg/ day, it should be noted that toxicities have also occurred with lower intermittent dosing regimens. [3][4][5][6][7] Therefore, the 300-to 450-mg twice-daily rifampin regimens recommended for PJIs may place patients at increased risk of developing hematologic toxicities. 1,2 Utilization of the Naranjo adverse drug reaction probability score demonstrated a probable (score of 5) relationship between rifampin and thrombocytopenia.…”

“…1,2 Although rifampin toxicities, such as hepatotoxicity and hematologic toxicity, are well known in the management of TB, there is a paucity of data describing toxicities in the setting of hardware infections. 3-7…”