Rifampicin-induced upper gastrointestinal bleeding

Zargar, Showkat Ali; Thapa, Babu Ram; Sahni, Ankita; Mehta, Sahil

doi:10.1136/pgmj.66.774.310

Cited by 11 publications

(8 citation statements)

References 6 publications

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“…In contrast, TAA induced a variety of modest vascular leak changes in a variety of tissues; however, the predominant AMT-750 changes were seen in the liver and spleen once the signal was corrected for a nonspecific vascular leak. Most of our findings, here using a single dose of chemical agent, are supported by previously published studies performed after repeated dosing of RMP (Poole et al, 1971; Bykova et al, 1977; Roszkowski et al, 1984; Katz and Lor, 1986; Zargar et al, 1990; Sodhi et al, 1997; Tassaduq et al, 2011; Chiba et al, 2013) or TAA (al-Bader et al, 2000; Wang et al, 2004). …”

Section: Resultssupporting

confidence: 89%

“…It is interesting to note that the four other sets of tissues in which we expected to see some level of tissue change—spleen (TAA), kidney (RMP), stomach (RMP), and fat (TAA and RMP)—showed no overt signs of injury. This supports the expectation that biologic changes would likely precede overt signs of tissue injury, when one considers additional published data with repeated dosing in animals and human patients (Poole et al, 1971; Roszkowski et al, 1984; Katz and Lor, 1986; Zargar et al, 1990; al-Bader et al, 2000; Wang et al, 2004; Tassaduq et al, 2011; Kadir et al, 2013). …”

Section: Resultssupporting

confidence: 60%

“…To assess the potential benefit of combined screening for cell death, MMP activity, and transferrin receptor expression on the detection of DILI, we used fluorescent imaging probes specific for these biomarkers (AV-750, MMP-645, and TfV-750, respectively) to image the livers of animals receiving four different liver injury–inducing chemical compounds. Two of these compounds (TAA and APAP) are known to induce hepatocellular injury (McGill et al, 2012; Ackerman et al, 2015), a third drug (RMP) predominantly induces liver cholestasis (Zítková et al, 1982; Katz and Lor, 1986; Zargar et al, 1990), and a fourth drug (CPZ) induces mixed hepatocellular/cholestasis injury (Mullock et al, 1983). Serum ALT/ALP ratios can provide a rough mechanistic assessment, with hepatocellular injury defined as a ratio > 5, cholestasis as a ratio < 2, and mixed hepatocellular/cholestasis with a ratio between 2 and 5.…”

Section: Resultsmentioning

confidence: 99%

“…RMP is a widely used antimicrobial agent that is a crucial component in treatment regimens for tuberculosis. This drug causes hepato- and nephrotoxicity as well as abdominal cramps and stomach distension (Zítková et al, 1982; Katz and Lor, 1986; Zargar et al, 1990; Tassaduq et al, 2011). CPZ is widely used as a sedative or antiemetic and is also one of the primary antipsychotic medications used to treat schizophrenia.…”

Section: Methodsmentioning

confidence: 99%

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Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging

Vasquez

Peterson

2017

The Journal of Pharmacology and Experimental Therapeutics

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Hepatocellular and cholestatic forms of drug-induced liver injury (DILI) are major reasons for late-stage termination of small-molecule drug discovery research projects. Biochemical serum markers are limited in their ability to sensitively and specifically detect both of these common DILI forms in preclinical models, and tissue-specific approaches to assessing this are labor intensive, requiring extensive animal dosing, tissue preparation, and pathology assessment. In vivo fluorescent imaging offers noninvasive detection of biologic changes detected directly in the livers of living animals. Three different near-infrared fluorescent imaging probes, specific for cell death (Annexin-Vivo 750), matrix metalloproteases (MMPSense 750 FAST), and transferrin receptor (Transferrin-Vivo 750) were used to measure the effects of single bolus intraperitoneal doses of four different chemical agents known to induce liver injury. Hepatocellular injury–inducing agents, thioacetamide and acetaminophen, showed optimal injury detection with probe injection at 18–24 hours, the liver cholestasis-inducing drug rifampicin required early probe injection (2 hours), and chlorpromazine, which induces mixed hepatocellular/cholestatic injury, showed injury with both early and late injection. Different patterns of liver responses were seen among these different imaging probes, and no one probe detected injury by all four compounds. By using a cocktail of these three near-infrared fluorescent imaging probes, all labeled with 750-nm fluorophores, each of the four different DILI agents induced comparable tissue injury within the liver region, as assessed by epifluorescence imaging. A strategy of probe cocktail injection in separate cohorts at 2 hours and at 20–24 hours allowed the effective detection of drugs with either early- or late-onset injury.

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Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging

Vasquez

Peterson

2017

The Journal of Pharmacology and Experimental Therapeutics

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“…7 Terdapat sebuah laporan kasus yang melaporkan bahwa konsumsi rifampisin tanpa dibarengi konsumsi antipiretik atau analgesik dapat menyebabkan perdarahan saluran cerna bagian atas. 8 Gangguan saluran cerna pada pasien TB akan meningkatkan risiko terjadinya komplikasi malnutrisi. Sedangkan malnutrisi juga akan memperburuk manifestasi klinis dari tuberkulosis.…”

Section: Pendahuluanunclassified

Potensi Ekstrak Curcuma Xanthorrhiza Sebagai Terapi Pendamping Tuberkulosis

Hardi¹,

Setiawan²,

sadewa³

2021

Preprint

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Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Most of it attacks the lungs and is still a world health problem. Therapy with a combination of drugs called Anti-Tuberculosis Drugs (OAT) has become a standard and effective cure for TB sufferers as long as it is regular and complete. However, the drawback of OAT is that it has several side effects that allow temporary drug interruption and worsening of clinical manifestations. For that we need companion therapy to overcome this. The purpose of this paper is to search and analyze literature regarding the potential of Curcuma xanthorrhizol extract as a companion therapy for tuberculosis. The method used is by searching the pubmed and google scholar databases with the keywords curcuma xanthorrhiza, curcumin, xanthorrhizol, flavonoids, Mycobacterium tuberculosis, anti-inflammatory, anti-oxidant, gastroprotective and anti-bacterial. Then the literature is selected based on inclusion and exclusion criteria. The results and discussion obtained were that curcuma xanthorrhiza has various active compounds that are useful for preventing side effects of OAT such as curcumin, xanthorrhizol, and flavonoids. Curcuma xanthorrhiza can be used as anti-inflammatory, anti-oxidant, gastroprotective so that side effects such as skin rashes, nausea, vomiting, abdominal pain and others can be prevented. Besides that, curcumin content in Curcuma xanthorrhiza has anti-tuberculosis activity. The conclusion is that curcuma xanthorrhiza extract can be considered as a companion drug for TB patients. It can be done further research on the potential of ginger

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Rifamycins

2006

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions

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Rifampicin-induced upper gastrointestinal bleeding

Cited by 11 publications

References 6 publications

Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging

Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging

Potensi Ekstrak Curcuma Xanthorrhiza Sebagai Terapi Pendamping Tuberkulosis

Rifamycins

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