Rifampicin Nanoprecipitation using Flow Focusing Microfluidic Device

Schianti, Juliana N.

doi:10.4172/2157-7439.1000172

Cited by 15 publications

(13 citation statements)

References 34 publications

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“…The optimal formulation consisted of PVP in content of 89.02 mg and solid content of 900 mg was prepared by application of 120 W power input and acid addition with time interval of 15 s. Nearly spherical shape of optimized nanoparticles has been reported for other nanosuspensions. 9,25 Moreover, thermal analysis confirmed partial crystalline state of these particles. Difference in the morphology and crystalline structure of unprocessed cefixime and nanoparticles can affect both pharmaceutical and biopharmaceutical properties such as solubility and dissolution profile of the drug.…”

Section: Discussionmentioning

confidence: 68%

Optimization of Cefixime Nanosuspension to Improve Drug Dissolution

Ghasemian¹,

Rezaeian²,

Alaei³

et al. 2015

Pharm Sci

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Section: Discussionmentioning

confidence: 68%

Optimization of Cefixime Nanosuspension to Improve Drug Dissolution

Ghasemian¹,

Rezaeian²,

Alaei³

et al. 2015

Pharm Sci

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“…The size of the nanoparticles was significantly smaller and more uniform than that of the respective raw counterparts. The morphology of the particles suggests that the precipitation process inside our microfluidic device was fast, allowing the effective trapping of the drug nanoparticles in a less stable amorphous state [ 9 , 95 , 98 , 101 ]. These results further emphasize the advantage of the use of flow focusing techniques for the synthesis of additive-free nano-drugs of uniform size with enhanced saturation solubility and dissolution rates.…”

Section: Resultsmentioning

confidence: 99%

Excipient-Free Pure Drug Nanoparticles Fabricated by Microfluidic Hydrodynamic Focusing

et al. 2021

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Nanoprecipitation is one of the most versatile methods to produce pure drug nanoparticles (PDNPs) owing to the ability to optimize the properties of the product. Nevertheless, nanoprecipitation may result in broad particle size distribution, low physical stability, and batch-to-batch variability. Microfluidics has emerged as a powerful tool to produce PDNPs in a simple, reproducible, and cost-effective manner with excellent control over the nanoparticle size. In this work, we designed and fabricated T- and Y-shaped Si-made microfluidic devices and used them to produce PDNPs of three kinase inhibitors of different lipophilicity and water-solubility, namely imatinib, dasatinib and tofacitinib, without the use of colloidal stabilizers. PDNPs display hydrodynamic diameter in the 90–350 nm range as measured by dynamic light scattering and a rounded shape as visualized by high-resolution scanning electron microscopy. Powder X-ray diffraction and differential scanning calorimetry confirmed that this method results in highly amorphous nanoparticles. In addition, we show that the flow rate of solvent, the anti-solvent, and the channel geometry of the device play a key role governing the nanoparticle size.

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“…This 3D device is operated in the coaxial flow regimen in order to carry out the nanoprecipitation process [38,39].…”

Section: Fabrication Of Ltcc 3d Microfluidic Reactorsmentioning

confidence: 99%

LTCC-3D Coaxial Flow Focusing Microfluidic Reactor for Micro and Nanoparticle Fabrication and Production Scale-Out

Gongora-Rubio¹,

Schianti²,

Gomez³

et al. 2013

Journal of Microelectronics and Electronic Packaging

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AbstractÀMiniaturization of chemical processes is becoming a must for green chemistry and sustainable industry processes, so technological research in this direction is well received. Continuous microreactor systems hold many potential benefits over batch reactors, in that they allow: high surface-to-volume ratio, fine adjustment of chemical reaction residence times, small thermal inertia, and fast changes in temperature. Advantages of multilayer green ceramics for microprocess applications include: that the LTCC substrate is chemically inert to most solvents, that it has a high contact angle, that it presents low thermal coefficient of expansion, and that it can withstand high operational temperatures and high internal pressures. For these reasons, LTCC-based microsystem technologies allow the implementation of different unitary operations for chemical processes, making it an enabling technology for the miniaturization of chemical processes. In fact, recently, LTCC microfluidic reactors have been used to produce microparticles and nanoparticles with excellent control of size distribution and morphology. The present work provides a report on the performance of a 3D LTCC coaxial flow focusing microfluidic reactor designed to fabricate microparticles and nanoparticles using nanoprecipitation through an antisolvent; with electric potential size tuning. We also implement an approach to particle production scale-out.

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Rifampicin Nanoprecipitation using Flow Focusing Microfluidic Device

Cited by 15 publications

References 34 publications

Optimization of Cefixime Nanosuspension to Improve Drug Dissolution

Optimization of Cefixime Nanosuspension to Improve Drug Dissolution

Excipient-Free Pure Drug Nanoparticles Fabricated by Microfluidic Hydrodynamic Focusing

LTCC-3D Coaxial Flow Focusing Microfluidic Reactor for Micro and Nanoparticle Fabrication and Production Scale-Out

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