Rifampin in dermatology

Tsankov, Nikolaï; Angelova, Irena

doi:10.1016/j.disamonth.2004.05.008

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Rifampicin is highly soluble and effective for the treatment of abscesses and granulomas with a broad‐spectrum activity against gram positive and negative bacteria (especially Staphylococcus aureus and coagulase‐negative staphylococci) and also on bacterial biofilms 15 . On the other hand, clindamycin is active against gram‐positive cocci and most anaerobic‐bacteria, 16 with good topical formulation results in inflammatory HS nodules 17 .…”

Section: Discussionmentioning

confidence: 99%

Systemic antibiotics in hidradenitis suppurativa: efficacy and effects of body mass index and smoking pack‐year on the response to therapy

Iannone

Janowska

Bartolomei

et al. 2021

Dermatologic Therapy

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The combination of oral clindamycin with rifampicin is recommended by European guidelines as a first‐line treatment in moderate‐to‐severe hidradenitis suppurativa (HS). Recent studies highlight that oral clindamycin in monotherapy (CM) may be a useful alternative treatment. We included 36 patients with a diagnosis of moderate‐to‐severe HS. A total of 19 patients were treated with combination oral clindamycin plus rifampicin (C + R) and 17 with oral CM for 12 weeks. The efficacy of CM vs C + R was analyzed by multilinear regression models which showed a higher reduction in mSartorius (Δ = −13.2, P = .058) and AISI (Δ = −4.91, P = .034) in the C + R group. In the C + R group, smoking pack‐year was positively correlated with AISI (Spearman's rho = 0.51, P = .036) and with DLQI (0.47, P = .061). In the CM group, a positive correlation was found between BMI and AISI (0.47, P = .041). The data on the efficacy of C + R combination therapy are in line with guidelines, evidence‐based approaches, and recommendations from the HS ALLIANCE working group. The rationale for combining these two drugs is to increase bactericidal action and to reduce rifampicin resistance, as rifampicin is highly mutagenic. Our results suggest that the antibiotic combination of C + R is still the treatment of choice in moderate‐to‐severe HS with abscesses, draining fistulae and ≥ 5 inflammatory nodules. High BMI and smoking habits seem to be predictive factors of a poor response to antibiotics. Further multicenter studies and prospective randomized controlled trials are needed to confirm these results. Potential alternative antibiotic therapies should also be investigated.

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Section: Discussionmentioning

confidence: 99%

Systemic antibiotics in hidradenitis suppurativa: efficacy and effects of body mass index and smoking pack‐year on the response to therapy

Iannone

Janowska

Bartolomei

et al. 2021

Dermatologic Therapy

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“…Suas principais reações adversas são: lesões cutâneas, prurido na região facial, lacrimejamento, desordens do TGI, púrpura trombocitopênica, insuficiência renal, distúrbios hepáticos e síndrome pseudogripal. 10 Observa-se que tais drogas podem apresentar efeitos adversos que prejudicam a adesão ao tratamento. Isso somado a falta de apoio médico-familiar, baixa escolaridade, precárias condições socioeconômicas, inaptidão profissional na identificação e orientação dos principais efeitos colaterais, torna a terapia ainda mais prejudicada.…”

Section: Introductionunclassified

Principais Alterações Clínicas Responsáveis Pela Substituição Da Poliquimioterapia Para Hanseníase: Um Levantamento De 11 Anos Em Uma Microrregião No Sul De Tocantins

Castro

Soares²,

Candido³

et al. 2019

Rev Pat Tocantins

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Objetivo: Avaliar as principais alterações clínicas responsáveis pela troca do esquema padrão anti-hansênico e traçar o perfil epidemiológico destes pacientes, em caráter regional. Métodos: Estudo transversal, retrospectivo utilizando prontuários dos pacientes com hanseníase de Janeiro de 2006 a Dezembro de 2016, na unidade de saúde Policlínica Luiz Santos Filho, Gurupi-Tocantins, com enfoque para os casos em uso de esquema alternativo. Resultados: Registrou-se 1.240 casos de hanseníase no município, destes, 86 (6,93%) foram intolerantes à poliquimioterapia inicial. A Dapsona foi a droga mais substituída, 88,37% dos casos. A síndrome anêmica foi a principal alteração encontrada (56,97%). Não houve correlação significativa entre o número de notificações e substituições (ρ = - 0,229) (α=0,05). Conclusões: Apesar da baixa taxa de substituições, é fundamental a capacitação das equipes de saúde no reconhecimento da intolerância medicamentosa no tratamento da hanseníase, fortalecendo adesão terapêutica e o combate a hanseníase enquanto problema de saúde pública. Palavras-chave: Hanseníase; Toxicidade de drogas; Quimioterapia combinada; Sintomas clínicos. ABSTRACT Objective: To evaluate the main clinical changes responsible for the substitution of the standard anti-leprosy treatment and identify the epidemiological profile of patients with leprosy on a regional basis. Methods: A cross-sectional retrospective study was conducted using records of patients with leprosy from January 2006 to December 2016 at the Luiz Santos Filho Polyclinic health unit, Gurupi-Tocantins, focusing on cases using an alternative treatment. Results: A total of 1,240 patients with leprosy were registered in the city, of which 86 (6.93%) were intolerant to initial polychemotherapy. Dapsone was the most commonly substituted drug in 88.37% of the cases. Anemic syndrome was the main change identified (56.97%). There was no significant correlation between the number of notifications and substitutions (ρ=-0.229) (α=.05). Conclusion: Despite the low substitution rates found, it is essential to train healthcare teams to recognize drug intolerance in the treatment of leprosy, improving therapeutic adherence and treating leprosy as a public health problem. Keywords: Leprosy; Drug toxicity; Drug combinations; Clinical symptoms.

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Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

Marcus

Mahmoud

Hamzavi³

2009

Arch Dermatol

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Background: Granuloma annulare (GA) is a benign, usually self-limiting, dermatosis, that typically presents as asymptomatic, flesh-colored or erythematous papules, frequently arranged in an annular or arciform pattern on the distal extremities. Although localized GA is most commonly observed, a generalized or disseminated form can occur. The etiology of GA is unknown; however, multiple inciting factors have been proposed. Histologically, GA is characterized by foci of degenerative collagen associated with palisading, sometimes infiltrating granulomatous inflammation. Observations: We report 6 cases with biopsy-proved GA, resistant to the standard modalities of treatment that resolved after 3 months with monthly rifampin (600 mg), ofloxacin (400 mg), and minocycline hydrochloride (100 mg) combination therapy. Rifampin, ofloxacin, and mi-nocycline combination therapy has been successfully used to treat patients with paucibacillary leprosy. Given reports that prolonged antibiotic agents are a useful treatment for GA, rifampin (600 mg), ofloxacin (400 mg), and minocycline hydrochloride (100 mg) combination therapy was initiated in these patients. Complete clearance of the plaques was achieved 3 to 5 months after the initiation of treatment. Some patients experienced postinflammatory hyperpigmentation. Conclusion: Although our treatment was effective, further studies may be needed to confirm the success of this therapeutic option for patients with recalcitrant lesions of GA.

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Rifampin in dermatology

Cited by 3 publications

References 40 publications

Systemic antibiotics in hidradenitis suppurativa: efficacy and effects of body mass index and smoking pack‐year on the response to therapy

Systemic antibiotics in hidradenitis suppurativa: efficacy and effects of body mass index and smoking pack‐year on the response to therapy

Principais Alterações Clínicas Responsáveis Pela Substituição Da Poliquimioterapia Para Hanseníase: Um Levantamento De 11 Anos Em Uma Microrregião No Sul De Tocantins

Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

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