Rift Valley fever in West Africa: A zoonotic disease with multiple socio-economic consequences

Tinto, Bachirou; Quellec, Jordan; Cêtre-Sossah, Catherine; Dicko, Amadou; Salinas, Sara; Simonin, Yannick

doi:10.1016/j.onehlt.2023.100583

Cited by 9 publications

(3 citation statements)

References 112 publications

(237 reference statements)

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“…Capripoxvirus infections are very common in large parts of Africa, Asia and the Middle East, and they affect both cattle and small ruminants [ 47 , 53 ]. These same animal populations are challenged by RVFV infection [ 54 ]. To address this possible interference, this study was conducted to evaluate the safety and potency of a combined LSD/CBPP and monovalent RVF freeze-dried vaccines to be injected separately and simultaneously into the same animals.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the LSD/CBPP+RVF vaccine was tested at the laboratory level for safety in young and pregnant females, antibody response to vaccination and efficacy through the challenge of the vaccinated animals with virulent pathogens. In addition, the vaccine was tested on a large number of animals in an area where these disease pathogens are enzootic [ 54 , 57 ]. The vaccine was completely safe, and vaccinated calves remained healthy with no excessive local swelling at the injection sites.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of a Combined Live Attenuated Vaccine against Lumpy Skin Disease, Contagious Bovine Pleuropneumonia and Rift Valley Fever

Bamouh,

Elarkam,

Elmejdoub

et al. 2024

Vaccines

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The use of effective vaccines is among the most important strategies for the prevention and progressive control of transboundary infectious animal diseases. However, the use of vaccine is often impeded by the cost, a lack of cold chains and other factors. In resource-limited countries in Africa, one approach to improve coverage and reduce cost is to vaccinate against multiple diseases using combined vaccines. Therefore, the objective of this study was to evaluate a combined vaccine for the prevention and control of Lumpy Skin Disease (LSD), Contagious Bovine Pleuropneumonia (CBPP) and Rift Valley fever (RVF). The LSD and CBPP were formulated as a combined vaccine, and the RVF was formulated separately as live attenuated vaccines. These consisted of a Mycoplasma MmmSC T1/44 strain that was propagated in Hayflick-modified medium, RVF virus vaccine, C13T strain prepared in African green monkey cells (Vero), and the LSDV Neethling vaccine strain prepared in primary testis cells. The vaccines were tested for safety via the subcutaneous route in both young calves and pregnant heifers with no side effect, abortion or teratogenicity. The vaccination of calves induced seroconversions for all three vaccines starting from day 7 post-vaccination (PV), with rates of 50% for LSD, 70% for CBPP and 100% for RVF, or rates similar to those obtained with monovalent vaccines. The challenge of cattle vaccinated with the LSD/CBPP and the RVF vaccine afforded full protection against virulent strains of LSDV and RVFV. A satisfactory level of protection against a CBPP challenge was observed, with 50% of protection at 6 months and 81% at 13 months PV. A mass vaccination trial was performed in four regions of Burkina Faso that confirmed safety and specific antibody responses induced by the vaccines. The multivalent LSD/CBPP+RVF vaccine provides a novel and beneficial approach to the control of the three diseases through one intervention and, therefore, reduces the cost and improves vaccination coverage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of a Combined Live Attenuated Vaccine against Lumpy Skin Disease, Contagious Bovine Pleuropneumonia and Rift Valley Fever

Bamouh,

Elarkam,

Elmejdoub

et al. 2024

Vaccines

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“…In Senegal, RVFV was highly detected in 1987 and, since then, recurrent epidemics, interspersed with inter-epidemic periods, have occurred [8,18]. Mauritania has also been affected by several RVFV outbreaks.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of two Rift Valley fever virus field strains circulating in Mauritania in 2010 and 2013 reveals the high virulence of the MRU25010-30 strain isolated from camel

Chabert,

Lacôte,

Marianneau

et al. 2024

Preprint

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Rift Valley fever (RVF) is one of the major viral arthropod-borne diseases in Africa. In recent decades, RVF virus (RVFV), the causative agent of RVF, has been responsible for multiple outbreaks in West Africa with important consequences on human and animal health. In particular, an outbreak occurred in 2010 after heavy rainfalls in the desertic region of Adrar, Mauritania. It was characterized by the appearance of severe clinical signs among dromedary camels. Another one occurred in 2013-2014 across Senegal and the southern part of Mauritania. In this study, we characterized two RVFV field strains isolated during these two outbreaks. The first strain, MRU25010-30, has been isolated in camel (2010) while the second, MRU2687-3, was isolated in goat (2013). By deep-sequencing and rapid amplification of cDNA-ends by polymerase chain reaction (RACE-PCR), we successfully sequenced the complete genome of these two RVFV strains as well as the reference laboratory strain ZH548. Phylogenetic analysis shows that the two field viruses belong to two different RVFV genetic lineages. Moreover, we show that MRU25010-30 replicates more efficiently in various in vitro cell culture models than MRU2687-3 and ZH548. In vivo, MRU25010-30 caused rapid death of BALB/c mice and proved to be more virulent than MRU2687-3, regardless of the route of inoculation (subcutaneous or intranasal). The virulence of MRU25010-30 is associated with a high viral load in the liver and serum of infected mice, while the death of mice infected with MRU2687-3 and ZH548 correlates with a high viral load in the brain. Altogether, the data presented in this study provide new avenues to unveil the molecular viral determinants that modulate RVFV virulence and replication capacity

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Human Riboviruses: A Comprehensive Study

Mohan,

Choudhury,

Bhat

et al. 2024

J Mol Evol

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Rift Valley fever in West Africa: A zoonotic disease with multiple socio-economic consequences

Cited by 9 publications

References 112 publications

Evaluation of a Combined Live Attenuated Vaccine against Lumpy Skin Disease, Contagious Bovine Pleuropneumonia and Rift Valley Fever

Evaluation of a Combined Live Attenuated Vaccine against Lumpy Skin Disease, Contagious Bovine Pleuropneumonia and Rift Valley Fever

Comparative study of two Rift Valley fever virus field strains circulating in Mauritania in 2010 and 2013 reveals the high virulence of the MRU25010-30 strain isolated from camel

Human Riboviruses: A Comprehensive Study

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