Right Brodmann area 18 predicts tremor arrest after Vim radiosurgery: a voxel-based morphometry study

Tuleasca, Constantin; Witjas, Tatiana; Ville, Dimitri Van De; Najdenovska, Elena; Verger, Antoine; Girard, Nadine; Champoudry, J.; Thiran, Jean‐Philippe; Cuadra, Meritxell Bach; Levivier, Marc; Guedj, Éric; Régis, Jean

doi:10.1007/s00701-017-3391-x

Cited by 27 publications

(22 citation statements)

References 44 publications

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“…Moreover, using the same methodology (i.e., seed-based approach) and in a second study, we coined the term cerebello-thalamo-visuo-motor network to describe the fact that pretherapeutic VLV FC with right visual association area (Brodmann area, BA19) predicted 1-year activities of daily living (ADL; Bain et al, 1993) decrease. This revelation of visual areas implicated in ET followed other publications from our group, on the same topic, on both functional (please see below) and structural aspects Tuleasca, Witjas, van de Ville, et al, 2017).…”

Section: Dear Editorsupporting

confidence: 79%

Graph theory analysis of resting‐state functional magnetic resonance imaging in essential tremor

Tuleasca

Bolton

Régis³

et al. 2019

Human Brain Mapping

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Section: Dear Editorsupporting

confidence: 79%

Graph theory analysis of resting‐state functional magnetic resonance imaging in essential tremor

Tuleasca

Bolton

Régis³

et al. 2019

Human Brain Mapping

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“…The importance of brain visual areas in tremor pathogenesis has been recently investigated by using a visual task of increasing difficulty to illustrate the impact of visuospatial network in tremor augmentation (Archer et al, 2018). Furthermore, recent series of investigations suggested that structural and functional changes of the visual cortex could be a preoperative predictor of optimum tremor outcome after ablative radiosurgery (Tuleasca et al, 2017(Tuleasca et al, , 2018b(Tuleasca et al, , 2018c.…”

Section: The Tremor Network and Pattern Of Beneficial Dbs Connectivitymentioning

confidence: 99%

Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor

Al‐Fatly

Ewert

Kübler

et al. 2019

Preprint

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Essential tremor is the most prevalent movement disorder and is often refractory to medical treatment. Deep brain stimulation offers a therapeutic approach that can efficiently control tremor symptoms. Several deep brain stimulation targets (ventral intermediate nucleus, zona incerta, posterior subthalamic area) have been discussed for tremor treatment. Effective deep brain stimulation therapy for tremor critically involves optimal targeting to modulate the tremor network. This could potentially become more robust and precise by using state-of-the-art brain connectivity measurements. In the current study, we utilized two normative brain connectomes (structural and functional) to show the pattern of effective deep brain stimulation electrode connectivity in 36 essential tremor patients. Our structural and functional connectivity models were significantly predictive of post-operative tremor improvement in out-of-sample data (p < 0.001 for both structural and functional leave-one-out cross-validation). Additionally, we segregated the somatotopic brain network based on head and hand tremor scores. These resulted in segregations that mapped onto the well-known somatotopic maps of both motor cortex and cerebellum. Crucially, this shows that slightly distinct networks need to be modulated to ameliorate head vs. hand tremor and that those networks could be identified based on somatotopic zones in motor cortex and cerebellum.Finally, we propose a multi-modal connectomic deep brain stimulation sweet spot that may serve as a reference to enhance clinical care, in the future. This spot resided in the posterior subthalamic area, encroaching on the inferior borders of ventral intermediate nucleus and sensory thalamus.Our results underscore the importance of integrating brain connectivity in optimizing deep brain stimulation targeting for essential tremor.

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“…Neuroimaging, including multimodal MRI and PET, could provide additional insights into ET physiopathology. In this vein, recent MRI studies have reported the involvement of the visuo-motor network in ET in VBM studies 12,13 and fMRI studies 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Metabolic Positron Emission Tomography Response to Gamma Knife of the Ventral Intermediate Nucleus in Essential Tremor

et al. 2018

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Right Brodmann area 18 predicts tremor arrest after Vim radiosurgery: a voxel-based morphometry study

Abstract: Routine baseline structural neuroimaging predicts TSTH improvement 1 year after Vim RS. The relevant anatomical area is the right visual association cortex (BA 18, V2). The question whether visual areas should be included in the targeting remains open.

Cited by 27 publications

References 44 publications

Graph theory analysis of resting‐state functional magnetic resonance imaging in essential tremor

Graph theory analysis of resting‐state functional magnetic resonance imaging in essential tremor

Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor

Metabolic Positron Emission Tomography Response to Gamma Knife of the Ventral Intermediate Nucleus in Essential Tremor

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