Right- / left-circular orientation of biological macromolecules under magnetic field gradient

Hirai, Mitsuhiro; Koizumi, Masaharu; Han, Ruqi; Hayakawa, Tomohiro; Sano, You

doi:10.1107/s002188980300058x

Cited by 6 publications

(11 citation statements)

References 19 publications

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“…Furthermore, based on the anisotropic nature of the filamentous viruses, external stimuli such as electric and magnetic fields can be applied to tune the ordering, therefore allowing alignment of the whole sample. 13, 520, 521 …”

Section: Applications Of Virus-based Particlesmentioning

confidence: 99%

Design of virus-based nanomaterials for medicine, biotechnology, and energy

2016

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Virus-based nanomaterials are versatile materials that naturally self-assemble and have relevance for a broad range of applications including medicine, biotechnology, and energy. This review provides an overview of recent developments in “chemical virology.” Viruses, as materials, provide unique nanoscale scaffolds that have relevance in chemical biology and nanotechnology, with diverse areas of applications. Some fundamental advantages of viruses, compared to synthetically programmed materials, include the highly precise spatial arrangement of their subunits into a diverse array of shapes and sizes and many available avenues for easy and reproducible modification. Here, we will first survey the broad distribution of viruses and various methods for producing virus-based nanoparticles, as well as engineering principles used to impart new functionalities. We will then examine the broad range of applications and implications of virus-based materials, focusing on the medical, biotechnology, and energy sectors. We anticipate that this field will continue to evolve and grow, with exciting new possibilities stemming from advancements in the rational design of virus-based nanomaterials.

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Section: Applications Of Virus-based Particlesmentioning

confidence: 99%

Design of virus-based nanomaterials for medicine, biotechnology, and energy

2016

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“…In the magnetic circuit (Figure 5a,b), the ferromagnetic, ferrimagnetic, paramagnetic, and antiferromagnetic particles at sample position numbers 3–5 move toward 4 25,26 . Conversely, the diamagnetic particles at sample position numbers 4–6 move toward 5.…”

Section: Resultsmentioning

confidence: 99%

“…The magnetic response analyses of clISCA1 by SAXS measurements with a periodic Nd–Fe–B permanent magnetic circuit were conducted at BL‐10C at PF (Figure 5a). 25,26 In the magnetic circuit, the magnetic flux B and its gradient Δ B along the x ‐axis are proportional to

\sin x

and

\cos x

, respectively (Figure 5b). 25,26 Here, x is the sample position on the x‐axis described in radians.…”

Section: Methodsmentioning

confidence: 99%

“…However, effect of the magnetic field on the structure and molecular behavior of clISCA1 has not been elucidated, making it challenging to discern the magnetic orientation mechanism of the clCRY4/clISCA1 oligomer and the function of clISCA1 on biomagnetoreception 20–24 . In this article, we report the magnetic field effects on the structure and molecular behavior of clISCA1 clarified by small‐angle X‐ray scattering (SAXS) analyses coupled with the SEC‐SAXS and an Nd–Fe–B permanent magnetic circuit device 25,26 . Here, a strong magnetic field (~1 T) was utilized to clearly detect the magnetic field effects on clISCA1 in the same manner as the magnetic orientation studies of some other biomacromolecules 17–19,25,26 …”

Section: Introductionmentioning

confidence: 99%

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Magnetic field effects on the structure and molecular behavior of pigeon iron–sulfur protein

et al. 2022

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Pigeon iron–sulfur (Fe–S) cluster assembly 1 homolog (clISCA1) is a target protein for research into the biomagnetoreception mechanism, as the clCRY4/clISCA1 oligomer, a complex composed of the columnar clISCA1 oligomer and the magnetosensor candidate protein cryptochrome‐4 (clCRY4) oligomer, tends to orient itself along weak magnetic fields, such as geomagnetic fields, under blue light. To obtain insight into the magnetic orientation mechanism of the clCRY4/clISCA1 oligomer, we inspected magnetic field effects on the structure and molecular behavior of clISCA1 by small angle X‐ray scattering analysis. The results indicated that the clISCA1 protomer took the Fe–S cluster‐bound globular form and unbound rod‐like form. The globular clISCA1 protomer assembled to form columnar oligomers, which allowed for the binding of many Fe–S clusters at the interface between clISCA1 protomers. Moreover, the translational diffusion and the columnar oligomerization of clISCA1 were controlled by the external static magnetic field and Fe–S clusters bound to clISCA1. However, the columnar clISCA1 oligomer was not oriented along the external static magnetic field (~1 T) when clCRY4 was not bound to clISCA1. This result indicated that clCRY4 has a function to enhance the magnetic orientational property of clCRY4/clISCA1 oligomer.

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“…This can be induced and controlled through functionalization of the viral scaffold with solvatochromic dyes (Johnson et al 2007) to orient the rods at liquid–liquid interfaces (solvent–water mixtures). Alignment can also be triggered through external control, such as with electric or magnetic fields (Ermolina et al 2006; Hirai et al 2003; Lee et al 2002). One can thus control the nematic direction of the ordered phase and enforce the whole sample to remain in a single domain, which would not occur if allowed to order spontaneously without the symmetry-breaking external field.…”

Section: Hierarchical Virus-based Assemblies—toward Metamaterialsmentioning

confidence: 99%

Photonics and plasmonics go viral: self-assembly of hierarchical metamaterials

Wen

Podgornik

Strangi

et al. 2015

Rend. Fis. Acc. Lincei

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Sizing and shaping of mesoscale architectures with nanoscale features is a key opportunity to produce the next generation of higher-performing products and at the same time unveil completely new phenomena. This review article discusses recent advances in the design of novel photonic and plasmonic structures using a biology-inspired design. The proteinaceous capsids from viruses have long been discovered as platform technologies enabling unique applications in nanotechnology, materials, bioengineering, and medicine. In the context of materials applications, the highly organized structures formed by viral capsid proteins provide a 3D scaffold for the precise placement of plasmon and gain materials. Based on their highly symmetrical structures, virus-based nanoparticles have a high propensity to self-assemble into higher-order crystalline structures, yielding hierarchical hybrid materials. Recent advances in the field have led to the development of virus-based light harvesting systems, plasmonic structures for application in high-performance metamaterials, binary nanoparticle lattices, and liquid crystalline arrays for sensing or display technologies. There is still much that could be explored in this area, and we foresee that this is only the beginning of great technological advances in virus-based materials for plasmonics and photonics applications.

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Right- / left-circular orientation of biological macromolecules under magnetic field gradient

Cited by 6 publications

References 19 publications

Design of virus-based nanomaterials for medicine, biotechnology, and energy

Design of virus-based nanomaterials for medicine, biotechnology, and energy

Magnetic field effects on the structure and molecular behavior of pigeon iron–sulfur protein

Photonics and plasmonics go viral: self-assembly of hierarchical metamaterials

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