ZusammenfassungAn der Veterinärmedizinischen Universität Wien wurden zwei Pferde aufgrund ähnlicher Symptomatik vorgestellt. Es handelte sich zum einen um eine 7-jährige Warmblutstute, die seit 2 Wochen eine unilateraler Ptosis und ipsilateralen Schweißausbruch an Kopf, Hals und Vordergliedmaße zeigte. Bei dem zweiten Patienten handelte es sich um einen 15-jährigen Paint-Wallach, der ebenfalls seit zwei Wochen beidseitigen Schweißausbruch an Kopf und Hals, sowie einseitige Ptosis zeigte. Mittels Ultraschalluntersuchung konnte bei beiden Tieren ein thorakaler Erguss festgestellt werden, der daraufhin punktiert wurde. This case series describes two horses with a diagnosis of Horner's syndrome as sequelae of thoracic neoplasia. The first case was a seven year old pregnant Warmblood mare presented at the Equine Clinic of the University of Veterinary Medicine in Vienna with a history of unilateral ptosis and sweating on the left side of the head, neck and thoracic limb of two weeks duration. Clinical examination revealed ptosis of the left eye; this was reversed after administration of 0.5 % phenylephrine. During rectal examination a mass at the mesenteric root was reached with the finger tips. The second case was a 15-year old Paint-gelding presented with bilateral sweating on head and neck as well as unilateral ptosis and an enlargement of the right Ln. cervicalis superficialis since two weeks. In both cases, no further neurological abnormalities were detected during a neurological examination. Fluid accumulation was detected by ultrasonography; thoracocentesis was performed and yielded grossly abnormal fluid. Cytological evaluation of the fluid samples revealed neoplastic cells indicating a carcinoma in the Warmblood mare and a lymphoma in the Paint gelding. In both cases, a hopeless prognosis was given, and the Warmblood mare was subjected to euthanasia at the clinic, while the owners of the Paint gelding elected euthanasia at home. In the Warmblood mare, gross pathology and histology were performed confirming an adenocarcinoma originating from the intestine metastasizing into other abdominal organs and into the thoracic cavity. A metastatic mass was detected adjacent to and infiltrating the left ganglion stellatum. Therefore the clinical signs in this case were attributed to the neoplasia within the thoracic cavity with subsequent Horner s syndrome. In the Gelding an immature lymphoid cell population in the effusion and an enlarged lymph-node had to suffice as a final diagnosis as the owner declined further diagnostic workup.Horner s syndrome is a collection of symptoms associated with pathology of the sympathetic nerve supply to the head. Lesions leading to a Horner s syndrom can be found in the brain (hypothalamus, ventrolateral medulla, ventral mid-brain, pons), the cervical spinal cord, the thoracic cavity, the vagosympathetic trunk or the guttural pouch. Equine dysautonomia is another entity typically leading to bilateral Horner s syndrome. The classical combination of the three symptoms ptosis, miosis and ...