with a tendency to significance for myometrial invasion (P = 0.065) by univariate analysis (v 2 ) ( Table 1). Patients with a negative MTA3 immunohistochemical staining reaction showed better progression-free (P = 0.008), cause-specific (P < 0.001) and overall (P = 0.012) survival by univariate survival analysis ( Figure 3). Cox regression resulted in just one independent term that was predictive of progression-free survival, namely FIGO stage (P < 0.001). Independent prognostic factors for cause-specific survival were FIGO stage (P = 0.004), LVSI (P = 0.025), and MTA3 positivity (P = 0.001). Overall survival was also influenced only by FIGO stage (P < 0.001) ( Table 2).The data obtained revealed that MTA3 can be upregulated in human cancer cells and might contribute to a more aggressive phenotype. However, as only a few target genes of MTA3 have been identified, the consequence of MTA3 overexpression in human cancer cells is far from being understood. We here demonstrate for the first time that MTA3 is upregulated in advanced stages of uterine non-endometrial cancer, and is associated with FIGO surgical stage, lymph node involvement, and LVSI. In addition, MTA3 staining was associated with progression-free, cause-specific and overall survival of patients with non-endometrioid carcinomas. Overall, immunolabelling of MTA3 represents an independent prognostic factor for causespecific survival, suggesting that this antigen could be used as a simple and efficient parameter with which to identify high-risk patients.

Summary Ingestion of food contaminated with slaframine, an alkaloid produced by Rhizoctonia leguminicola, causes a mycotoxicosis, characterised by excessive salivation. Twenty‐eight horses demonstrated this clinical sign after the consumption of alfalfa hay which on inspection showed dark patches on many of the stems. The presence of slaframine (1.5 ppm) in this hay was confirmed by gas chromatography and mass spectroscopy. This is the first equine slaframine toxicosis case reported in Brazil.

Summary This study describes right laryngeal hemiplegia (LH) and right‐sided Horner's syndrome (HS) in a horse. The average temperature of the face was 3.5°C higher on the right compared with the left side, as determined by thermographic imaging. The syndrome occurred following an episode of right mid‐cervical cellulitis due to inadvertent perijugular deposition of gentamicin.

A 13-year-old female German Shepherd dog was euthanised and submitted to necropsy after a 7-month history of prolonged recumbency and vocalisation. Gross anatomical changes consisted of a well-demarcated, 3.5×1.5 cm, soft red mass that effaced the right lateral ventricle and compressed the adjacent neuroparenchyma. Histologically, elongate neoplastic cells with astrocytic morphology were arranged in short bundles and streams supported by a neuropil-like stroma. Neoplastic cells were immunopositive for glial fibrillar acidic protein (GFAP) and oligodendrocyte transcription factor 2 (Olig2), and immunonegative for e-cadherin and pancytokeratin. Histological and immunohistochemical features were consistent with a high-grade astrocytoma with ventricular invasion, a rare feature of astrocytic tumours in dogs.

ResumoO presente trabalho teve como objetivo fazer um levantamento da casuística de doenças dermatológicas auto-imunes e atualizar os dados referentes à ocorrência de lupus eritematoso discóide na população canina e felina atendida pelo Serviço de Dermatologia Veterinária da FMVZ-UNESP, campus de Botucatu, incluindo a espécie, sexo, raça, idade, localização e caracterização das lesões. Com a análise dos resultados, concluiu-se que a ordem de ocorrência de acordo com o número de casos de doenças dermatológicas auto-imunes nos animais atendidos pelo setor de dermatologia no período de 1988 a 2007 é: lupus eritematoso discóide, pênfigo foliáceo, síndrome úveo-dermatológica, pênfigo vulgar, lupus eritematoso sistêmico, eritema necrolítico migratório, eritema multiforme e pododermatite plasmocitária. Dos animais com lupus eritematoso discóide, todos eram da espécie canina, sendo a maioria fêmea e sem definição racial. As raças mais acometidas por lupus eritematoso discóide foram: Pastor Alemão e Akita e a média das idades foi de 56 meses. Notou-se que a maioria das lesões era localizada em plano nasal, narinas e região periocular. As lesões mais comumente observadas foram: crosta, despigmentação e eritema. Palavras-chave: Doenças de pele auto-imunes, lupus eritematoso discóide, cães, gatos AbstractThe objectives of this study were to do a survey of the autoimmune skin diseases and update the records regarding the occurrence of discoid lupus erythematosus in canine and feline populations attended