Right ventricular cardiac myxoma. Histopathology diagnosis in forensic autopsy case

Hecser, L; Siklodi, Katalin Palfi; Matei, Dumitru; Jung, Harald; Csiki, Gabor

doi:10.4323/rjlm.2011.79

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…The tumor typically projects from the endocardium into the cardiac chamber. It is believed that cardiac myxomas are derived from multipotential mesenchymal cells that persist as embryonal residues during septation of the heart [ 9 ]. They can be of variable size, shape, and mobility.…”

Section: ⧉ Discussionmentioning

confidence: 99%

The riddle of the right ventricle

Enache³

et al. 2021

Rom J Morphol Embryol

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Right ventricular (RV) myxoma is a very rare finding. Its differential diagnosis includes cardiac thrombus, and its risk of life-threatening complications mandates early diagnosis followed by surgical resection. We report the case of a patient with an incidental RV mass and a difficult differential diagnosis. A 66-year-old woman, first assessed in neurosurgery due to a lumbar herniated disc, was referred to cardiology for examination before proceeding to surgery. She complained of dyspnea on exertion present for the last few months and reported no fainting or syncope. Clinical examination showed intermittent pulmonary systolic murmur. Transthoracic echocardiography revealed an oval-shaped sessile mobile mass (42/18 mm) attached to the anterior RV wall. Computed tomography confirmed the presence of a RV mass with lower attenuation than the myocardium and extension towards the pulmonary trunk, without other abdominal or pulmonary masses that would suggest a thrombus. Cardiac magnetic resonance imaging described an ovoid mass (47/16 mm) in the right ventricle, “clinging” to the apical trabeculae, swinging during the cardiac cycle, causing partial obstruction of the pulmonary valve during systole. The patient underwent surgical resection of the tumor. Macroscopic specimen showed a translucent polypoid mass with hemorrhagic areas. Microscopy confirmed the diagnosis of RV myxoma. The case illustrates the difficulty of establishing the correct etiological diagnosis of a cardiac mass, especially when located in the right ventricle. Multimodality imaging remains the cornerstone of noninvasive tissue characterization of cardiac masses, still requiring histopathological confirmation, particularly in the setting of conflicting imaging results.

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Section: ⧉ Discussionmentioning

confidence: 99%

The riddle of the right ventricle

Enache³

et al. 2021

Rom J Morphol Embryol

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“…Myxoma can recur in about 1-5% so that annual surveillance echocardiography is required to detect any intracardiac tumour recurrence (8).Myxoma may cause damage to mitral valve necessitating mitral valve repair or replacement (9). Occasionally myxomas are infected, in this circumstances there is a great danger of systemic embolization (10). The diagnosis depend on laboratory tests, chest x-rays, echocardiography with a high sensivity and specifity (90% -95%) respectively.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Myxoma Single Center Experience

Dawood¹

2015

J. Fac. Med Baghdad

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Background: cardiac myxoma is the most frequent primary cardiac tumour comprising 30 to 50%, they are benign tumours. They are most often reported in women in the third to sixth decade of life. Objectives: is to evaluate the incidence of surgery of cardiac myxomas and their presentation and outcome in IbnAl-NafeesTeaching hospital over 10 years. Patient and Methods: This is a retrospective study that was conducted in Ibn Al-Nafees Hospital from January 2005 to December 2014 on patients with cardiac myxoma. Twenty-five patients diagnosed preoperatively as having cardiac myxoma, they were admitted to the hospital and underwent clinical evaluation, investigation, and surgical treatment. Result: Cardiac myxomas constituted 1% of the total cardiac operations at our institute, the twenty-five patients who were studied were operated upon, the mean age of patients was 49 years and male-female ratio was 1:3.Occurrence of myxoma was more common in the left atrium 88% followed by right atrium 8% while only 1 patient had myxoma in right ventricle. One recurrence was noticed after surgery, only one early death observed in this study. Conclusion: Early surgical intervention with complete resection of the tumour is essential for the cure of the disease and to prevent tumour recurrence with subsequent reoperation that expose the patient to more serious complications, Echocardiography is the ideal diagnostic tool and it is needed in the long term followup of the patients.

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Cardiac Tumors

Capotosto

Elena

Massoni

et al. 2016

Am J Forensic Med Pathol

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In the past, cardiac tumors were a just clinical curiosity and the prognosis was poor. Surgical management became possible after the advent of cardiopulmonary bypass, and more recently, preoperative diagnosis was greatly improved by the development of echocardiography, computed tomography, and magnetic resonance imaging. The value of echocardiography for diagnosing cardiac mass lesions has become well established. Numerous advances have occurred in the last 5 decades, and the evolution of echocardiography involves the development of its many modalities. This review is intended to help echocardiologists and forensic pathologists in providing good medical practice when faced with the challenge of investigating unexpected clinical signs, particularly in young people, or unexpected postmortem findings.

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Right ventricular cardiac myxoma. Histopathology diagnosis in forensic autopsy case

Cited by 3 publications

References 38 publications

The riddle of the right ventricle

The riddle of the right ventricle

Cardiac Myxoma Single Center Experience

Cardiac Tumors

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