Fahr's disease refers to rare syndrome characterised by symmetrical and bilateral intracranial calcification. This disease refers to a sporadic or familial idiopathic calcification of the basal ganglia that may lead to neurological, psychiatric, and cognitive abnormalities. The origin and pathomechanism of this disorder are unknown, and is the reason why other cases with basal ganglia calcification remain asymptomatic.

Pulmonary amyloidosis is a rare disease, characterized by extracellular deposition of fibrillary protein in the lungs. Primary pulmonary amyloidosis is rare disease, that present focal or systemic characteristics. The secondary system form is generally related to neoplastic, infectious, or chronic inflammatory processes, chronic kidney disease, syphilis, leprosy, inflammatory bowel disease, osteomyelitis, parasitic infections, rheumatoid arthritis. We present the case of patient with diffuse pulmonary amyloidosis Key words: pulmonary amyloidosis, pathology myloidosis is not a single disease but a term for diseases that share a common feature: the extracellular deposition of pathologic insoluble fibrillar proteins in organs and tissues. In the mid-19 th century, Virchow adopted the botanical term "amyloid", meaning starch or cellulose, to describe abnormal extracellular material seen in the liver at autopsy [36]. Subsequently, amyloid was found to stain with Congo red, appearing red microscopically in normal light but apple green when viewed in polarized light [1,8]. In major development was the recognition that amyloid fibrils in primary amyloidosis are fragments of immunoglobin light chains [15]. Subsequently, it was determined that different proteins made up the amyloid fibrils in reactive [secondary] amyloidosis and familial amyloidosis [2], opening the way to specific therapies designed to target the source of fibrilprecursor production [9]. Amyloidosis is characterized by deposition of abnormal protein, fibrillary proteins material in extracellular tissue, in a variety of organs [9, 13, 31, 32]. It is a generic term for a heterogeneous group of diseases, including Alzheimer's disease and type II diabetes mellitus [28]. It can be hereditary or acquired potentially fatal or a merely accidental finding [13]. In a simplified way, the disease can be subdivided into localized or systemic form. It can also be classified as primary or secondary [23]. The respiratory system is frequently involved in patients with amyloidosis [6, 9, 17, 21, 35]. Amyloidosis of the respiratory tract was first described in 1877 by Lesser [31].

No abstract

Primary cardiac neoplasms are very rare as compared to metastatic tumors. Myxomas are the most common of the primary cardiac tumors. Myxomas represent almost 50% of cardiac masses with an incidence reported at one in 10000 autopsies. A greater percentage (75%) are located in the left atrium, of these, 90% originate from an area in the atrial septum near the fossa ovalis. Right atrial myxoma are un common beign three to four time less frequent that those located in the left atrium. The incidence of those arising in the left and right ventricles is 2.5-4%. We report on case of right ventricular cardiac myxoma, confirmation with histopathological examination, what is first case in forensic medicine practice.

Background: Spontaneous rupture of the esophagus (Boerhaave's syndrome) is a rare, well defined clinical syndrome caused by a longitudinal perforation of the esophagus. This syndrome was first described by Boerhaave in 1724. This severe disease causes high mortality rates and it is difficult to diagnose it not only because it is rare but also because it is frequently confused with other severe clinical conditions. Case presentation: In this report we present a unique case of Boerhaave's syndrome in a 49-year-old male patient. In the period October 16-21 2009 he was hospitalized with the diagnosis: septic shock, rupture of esophagus, ARDS. The patient died on October 21, 2009 by cardiac arrest. Conclusion: The rupture of the esophagus is a serious condition and its diagnosis is usually neglected during the initial assessment.