Rigid helical-like assemblies from a self-aggregating tripeptide

Bera, Santu; Mondal, Sudipta; Xue, Bin; Shimon, Linda J. W.; Cao, Yi; Gazit, Ehud

doi:10.1038/s41563-019-0343-2

Cited by 160 publications

(170 citation statements)

References 33 publications

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“…Before actuating properties of TS crystals can be explored as a platform for conversion of thermal energy to mechanical work, the range of their basic performance capabilities must be established based on commonly accepted performance indices. With exception of several special cases of organic materials with unusually high Young's moduli, organic crystals are generally known to be soft in nature, particularly when compared to metals and alloys. A large contribution to the mechanical properties of organic crystals is governed by intermolecular interactions, which are considerably weaker than the intramolecular (covalent) or metallic bonds.…”

Section: Discussionmentioning

confidence: 99%

Global Performance Indices for Dynamic Crystals as Organic Thermal Actuators

Karothu

Halabi

et al. 2020

Advanced Materials

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same basic thermodynamic principles of energy transduction and are collectively referred to as actuators. [1][2][3][4][5][6][7][8][9][10] While complex natural biomechanical systems have evolved to aid functions such as dispersal and survival, the artificially manufactured actuators are specifically designed for integration in mechatronic or adaptronic systems that range from miniature devices such as navigation and positioning systems in flying machines, to complex systems that can perform tasks in specific environments, such as humanoid robots and spacecraft. The current applications of actuators are many and diverse; they include sensors, [11,12] artificial muscles, [13] soft robotics, [14] and energy-harvesting materials. [15] Simple or complex actuating motions can be induced by heat, light, electricity, pressure, and moisture, among other stimuli, and can be realized with shape-memory polymers, [16] conductive fibers, [17] liquid crystal elastomers, [18] piezoelectric, [19] magnetostrictive, [20] and electromagnetic materials. [21] The energy supplied to the artificial actuators can vary from fluid pressure or flow in the pneumatics, to current, charge or voltage in the electromagnetic, piezoelectric and magnetostrictive actuators, to heat in shape memory and thermal expansion actuators.The active media in actuators include fluids, hard solids such as metals, and even complex soft matter such as tissuesensembles of cells with similar structure that act together to perform a specific function. While molecular crystals do not immediately appeal as working actuating medium, their dynamic properties have recently transpired as an alternative to other materials and they are thought to hold an untapped potential for miniature, soft actuating devices, quickly shaping up into a new research field, crystal adaptronics. [22,23] Smallscale demonstrations of the usefulness of molecular crystals as microscale devices, including cantilevers, [24,25] ratchets, [26] optical waveguides, [27][28][29][30][31][32][33][34][35][36] and other "crystal gears" [37] that can move or reshape are occasionally reported for dynamic crystals. Although being very illustrative, these demonstrations have thus far remained limited to a laboratory scale and have not been implemented in actual, functional devices. Some of the obstacles toward wider applications are difficulties with reproducible growth of crystals of predictable size without the use Crystal adaptronics is an emergent materials science discipline at the intersection of solid-state chemistry and mechanical engineering that explores the dynamic nature of mechanically reconfigurable, motile, and explosive crystals. Adaptive molecular crystals bring to materials science a qualitatively new set of properties that associate long-range structural order with softness and mechanical compliance. However, the full potential of this class of materials remains underexplored and they have not been considered as materials of choice in an engineer's toolbox. A set of general performance metric...

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Section: Discussionmentioning

confidence: 99%

Global Performance Indices for Dynamic Crystals as Organic Thermal Actuators

Karothu

Halabi

et al. 2020

Advanced Materials

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“…These features led to the application of self-assembling peptides in biology as well as nanotechnology. [9][10][11][12][13][14][15][16] Hydrogels are one typical outcome of the self-assembly process, where the formed fibers entangle to generate a 3D network. [17,18] Due to their potent hydrogelation, peptides have been extensively studied as supramolecular hydrogelators for various potential biotechnological and biomedical applications.…”

Section: Doi: 101002/adma201906043mentioning

confidence: 99%

Unusual Two‐Step Assembly of a Minimalistic Dipeptide‐Based Functional Hypergelator

et al. 2020

Self Cite

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Self‐assembled peptide hydrogels represent the realization of peptide nanotechnology into biomedical products. There is a continuous quest to identify the simplest building blocks and optimize their critical gelation concentration (CGC). Herein, a minimalistic, de novo dipeptide, Fmoc‐Lys(Fmoc)‐Asp, as an hydrogelator with the lowest CGC ever reported, almost fourfold lower as compared to that of a large hexadecapeptide previously described, is reported. The dipeptide self‐assembles through an unusual and unprecedented two‐step process as elucidated by solid‐state NMR and molecular dynamics simulation. The hydrogel is cytocompatible and supports 2D/3D cell growth. Conductive composite gels composed of Fmoc‐Lys(Fmoc)‐Asp and a conductive polymer exhibit excellent DNA binding. Fmoc‐Lys(Fmoc)‐Asp exhibits the lowest CGC and highest mechanical properties when compared to a library of dipeptide analogues, thus validating the uniqueness of the molecular design which confers useful properties for various potential applications.

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“…Furthermore, these techniques cannot discriminate chemical species in multicomponent systems. Recently, confocal laser scanning microscopy (CLSM) has emerged as a powerful tool for structural analysis of multicomponent supramolecular hydrogel systems (Figure ) . CLSM not only allows observation of supramolecular nanofibers and hydrogels without the need for a drying process but can also distinguish between chemical species through the use of appropriately designed fluorescent probes.…”

Section: Introductionmentioning

confidence: 99%

The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry: In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels

et al. 2020

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Multicomponent supramolecular hydrogels are promising scaffolds for applications in biosensors and controlled drug release due to their designer stimulus responsiveness. To achieve rational construction of multicomponent supramolecular hydrogel systems, their in‐depth structural analysis is essential but still challenging. Confocal laser scanning microscopy (CLSM) has emerged as a powerful tool for structural analysis of multicomponent supramolecular hydrogels. CLSM imaging enables real‐time observation of the hydrogels without the need of drying and/or freezing to elucidate their static and dynamic properties. Through multiple, selective fluorescent staining of materials of interest, multiple domains formed in supramolecular hydrogels (e. g. inorganic materials and self‐sorting nanofibers) can also be visualized. CLSM and the related microscopic techniques will be indispensable to investigate complex life‐inspired supramolecular chemical systems.

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Rigid helical-like assemblies from a self-aggregating tripeptide

Cited by 160 publications

References 33 publications

Global Performance Indices for Dynamic Crystals as Organic Thermal Actuators

Global Performance Indices for Dynamic Crystals as Organic Thermal Actuators

Unusual Two‐Step Assembly of a Minimalistic Dipeptide‐Based Functional Hypergelator

The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry: In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels

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