Ring-substituted quinolines as potential anti-tuberculosis agents

Vangapandu, Suryanarayana; Jain, M.; Jain, Rahul; Kaur, Sukhraj; Singh, Prati Pal

doi:10.1016/j.bmc.2004.03.045

Cited by 104 publications

(39 citation statements)

References 14 publications

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“…A number of them have been clinically used as antifungal, antibacterial and antiprotozoic drugs [1,2] as well as antituberculotic agents [3,4]. Some quinoline based compounds showed also antineoplastics, antiasthmatic and antiplatelet activity [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

RP-HPLC determination of lipophilicity in series of quinoline derivatives

et al. 2009

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Abstract:In the present paper we describe results on the synthesis and lipophilicity determination of a series of biologically active compounds based on their heterocyclic structure. For synthesis of styrylquinoline-based compounds we applied microwave irradiation and solid phase techniques. The correlation between RP-HPLC retention parameter log k (the logarithm of retention factor k) and log P data calculated in various ways is discussed, as well as, the relationships between the lipophilicity and the chemical structure of the studied compounds.© Versita Warsaw and Springer-Verlag Berlin Heidelberg.

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Section: Introductionmentioning

confidence: 99%

RP-HPLC determination of lipophilicity in series of quinoline derivatives

et al. 2009

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“…A number of them was clinically used as antifungal, antibacterial and antiprotozoic drugs [1,2] as well as antituberculotic agents [3,4]. Some quinoline based compounds showed also antineoplastics activity [5].…”

Section: Introductionmentioning

confidence: 99%

The reaction between [RuCl2(PPh3)3] and hydroxyquinoline carboxylic acid

et al. 2008

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The reactions of [RuCl 2 (PPh 3 ) 3 ] with 8-hydroxy-2-methyl-quinoline-7-carboxylic acid was examined, and a novel ruthenium(II) complex-[Ru(PPh 3 ) 2 (C 5 H 8 NO) 2 ]-was obtained. The compound was studied by IR, UV-vis spectroscopy, and X-ray crystallography. The molecular orbital diagram of the complex was calculated with the density functional theory (DFT) method. The spin-allowed singletsinglet electronic transitions of the compound were calculated using the time-dependent DFT method, and the UV-vis spectrum of the compound was discussed, on this basis. The luminescence property of the [Ru(PPh 3 ) 2 (C 5 H 8 NO) 2 ]was examined.

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“…It is commonly known that Mycobacterium tuberculosis has developed resistance to the majority of the existing drugs. Ring substituted quinolines have been reported as new structural class of anti-TB agents which can act by their mechanism and these are different from those of currently used drugs against a panel of drug sensitive and drug resistant strains (Vangapandu et al, 2004). Cancer is another major cause of the death in the world.…”

Section: Introductionmentioning

confidence: 99%