RIPK3‐Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation

Chen, Yun; Li, Xinshuai; Hua, Yuyun; Ding, Yue; Zhang, Wei

doi:10.1155/2021/6617816

Cited by 19 publications

(24 citation statements)

References 46 publications

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“…The inhibitor of necroptosis necrostatin-1 (nec-1) reduced visceral fat deposition and restored cognitive function and brain damage, but it did not result in any improvement on insulin sensitivity in prediabetic HFD rats ( Jinawong et al, 2020 ). RIPK3 deficiency alleviated myocardial injury, improved cardiac function, and attenuated necroptosis in mice with STZ-induced diabetic cardiomyopathy ( Chen et al, 2021 ). Our results suggest that necroptosis could be another pathway involved in kidney damage in diabetes to be explored.…”

Section: Discussionmentioning

confidence: 99%

Kidney microRNA Expression Pattern in Type 2 Diabetic Nephropathy in BTBR Ob/Ob Mice

et al. 2022

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Diabetic nephropathy (DN) is the main leading cause of chronic kidney disease worldwide. Although remarkable therapeutic advances have been made during the last few years, there still exists a high residual risk of disease progression to end-stage renal failure. To further understand the pathogenesis of tissue injury in this disease, by means of the Next-Generation Sequencing, we have studied the microRNA (miRNA) differential expression pattern in kidneys of Black and Tan Brachyury (BTBR) ob/ob (leptin deficiency mutation) mouse. This experimental model of type 2 diabetes and obesity recapitulates the key histopathological features described in advanced human DN and therefore can provide potential useful translational information. The miRNA-seq analysis, performed in the renal cortex of 22-week-old BTBR ob/ob mice, pointed out a set of 99 miRNAs significantly increased compared to non-diabetic, non-obese control mice of the same age, whereas no miRNAs were significantly decreased. Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys. The in silico prediction of potential targets for the 99 miRNAs highlighted inflammatory and immune processes, as the most relevant pathways, emphasizing the importance of inflammation in the pathogenesis of kidney damage associated to diabetes. Other identified top canonical pathways were adipogenesis (related with ectopic fatty accumulation), necroptosis (an inflammatory and regulated form of cell death), and epithelial-to-mesenchymal transition, the latter supporting the importance of tubular cell phenotype changes in the pathogenesis of DN. These findings could facilitate a better understanding of this complex disease and potentially open new avenues for the design of novel therapeutic approaches to DN.

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Section: Discussionmentioning

confidence: 99%

Kidney microRNA Expression Pattern in Type 2 Diabetic Nephropathy in BTBR Ob/Ob Mice

et al. 2022

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“…Some studies confirmed that myocardial cell necroptosis is observed in the hearts of diabetic patients and animal models ( 90 , 104 ). Recent studies described that activation of Ca2 + /calmodulin-dependent protein kinase (CaMKII) via a RIPK3-dependent manner or deficiency of sirtuin-3 (SIRT3) can exacerbate DCM through necroptosis enhancement in diabetic rats ( 105 , 106 ). Even so, direct evidence for the exact mechanism of necroptosis in DCM is not very clear and more in depth investigations are merited.…”

Section: Advance In Diabetic Cardiomyopathymentioning

confidence: 99%

Perspectives for Forkhead box transcription factors in diabetic cardiomyopathy: Their therapeutic potential and possible effects of salvianolic acids

Han

Huang

Xia

et al. 2022

Front. Cardiovasc. Med.

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Diabetic cardiomyopathy (DCM) is the primary cause of morbidity and mortality in diabetic cardiovascular complications, which initially manifests as cardiac hypertrophy, myocardial fibrosis, dysfunctional remodeling, and diastolic dysfunction, followed by systolic dysfunction, and eventually end with acute heart failure. Molecular mechanisms underlying these pathological changes in diabetic hearts are complicated and multifactorial, including but not limited to insulin resistance, oxidative stress, lipotoxicity, cardiomyocytes apoptosis or autophagy, inflammatory response, and myocardial metabolic dysfunction. With the development of molecular biology technology, accumulating evidence illustrates that members of the class O of Forkhead box (FoxO) transcription factors are vital for maintaining cardiomyocyte metabolism and cell survival, and the functions of the FoxO family proteins can be modulated by a wide variety of post-translational modifications including phosphorylation, acetylation, ubiquitination, arginine methylation, and O-glycosylation. In this review, we highlight and summarize the most recent advances in two members of the FoxO family (predominately FoxO1 and FoxO3a) that are abundantly expressed in cardiac tissue and whose levels of gene and protein expressions change as DCM progresses, with the goal of providing valuable insights into the pathogenesis of diabetic cardiovascular complications and discussing their therapeutic potential and possible effects of salvianolic acids, a natural product.

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“…These findings may open novel avenues for therapeutic strategies against diabetic cardiomyopathy. 78 …”

Section: Necroptosis In Human Diseases and Animal Modelsmentioning

confidence: 99%

The role of necroptosis in disease and treatment

Liu

Xie

Ren

et al. 2021

MedComm

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Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis, triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1), TNFR2, and Fas. In case that apoptosis process is blocked, necroptosis pathway is initiated with the activation of three key downstream mediators which are receptor‐interacting serine/threonine protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain‐like protein (MLKL). The whole process eventually leads to destruction of the cell membrane integrity, swelling of organelles, and severe inflammation. Over the past decade, necroptosis has been found widely involved in life process of human beings and animals. In this review, we attempt to explore the therapeutic prospects of necroptosis regulators by describing its molecular mechanism and the role it played in pathological condition and tissue homeostasis, and to summarize the research and clinical applications of corresponding regulators including small molecule inhibitors, chemicals, Chinese herbal extracts, and biological agents in the treatment of various diseases.

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RIPK3‐Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation

Cited by 19 publications

References 46 publications

Kidney microRNA Expression Pattern in Type 2 Diabetic Nephropathy in BTBR Ob/Ob Mice

Kidney microRNA Expression Pattern in Type 2 Diabetic Nephropathy in BTBR Ob/Ob Mice

Perspectives for Forkhead box transcription factors in diabetic cardiomyopathy: Their therapeutic potential and possible effects of salvianolic acids

The role of necroptosis in disease and treatment

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