Ripple-like intraocular lens damage from a neodymium:YAG laser

Js, Lee; Li, Chia-Yun; Lin, Yen–Chun; Chang, Shih-Yen; Lin, Ken‐Kuo

doi:10.1016/s0886-3350(02)01523-7

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…The conventional and currently only effective treatment of PCO is Nd:YAG‐laser capsulotomy, during which a high‐energy laser beam disrupts the opacified capsule. However, this treatment sometimes leads to serious complications, including alterations of the intraocular lens (IOL) optic,2, 3 increased intraocular pressure,4, 5 and even damage to the retina is discussed controversially 6, 7…”

Section: Introductionmentioning

confidence: 99%

A Polymeric Drug Depot Based on 7‐(2′‐Methacryloyloxyethoxy)‐4‐methylcoumarin Copolymers for Photoinduced Release of 5‐Fluorouracil Designed for the Treatment of Secondary Cataracts

Sinkel¹,

Greiner²,

Agarwal³

2010

Macro Chemistry & Physics

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The synthesis of a polymeric, photoresponsive drug‐delivery system on the basis of 4‐methylcoumarin‐side‐chain‐functionalized methacrylic copolymers with different degrees of functionalization is reported. Drug‐release experiments in solution indicated a maximum release of 22 µg of 5‐fluorouracil per 1 mg of polymer. Polymer analogous photochemical drug immobilization does not lead to observable intermolecular cross‐linking. Miscibility experiments with PMMA suggest that the bulk polymerization of homogeneous, transparent polymer sheets for intraocular lens fabrication, using MMA as the matrix monomer and incorporating the polymer‐drug conjugates as a functional component, is possible.

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Section: Introductionmentioning

confidence: 99%

A Polymeric Drug Depot Based on 7‐(2′‐Methacryloyloxyethoxy)‐4‐methylcoumarin Copolymers for Photoinduced Release of 5‐Fluorouracil Designed for the Treatment of Secondary Cataracts

Sinkel¹,

Greiner²,

Agarwal³

2010

Macro Chemistry & Physics

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“…16,17 Specific damage reports mandating explantation surgery include large cracks that cover greater than one third of the IOL surface, multiple holes occupying the majority of the central visual axis, and a severe ripple effect created by melted concentric rings. 28,29 The largest defect created in this study in either IOL type at highest energy did not exceed 0.2 mm. Moderate damage (less than 0.5 mm) to the lens most commonly leads to mild glare or decreased visual acuity that does not require surgery to remove the IOL.…”

Section: Discussionmentioning

confidence: 59%

“…While damage to the IOL is frequently reported, many of the damage sites are small pits or scratches with negligible effect on vision 16,17 . Specific damage reports mandating explantation surgery include large cracks that cover greater than one third of the IOL surface, multiple holes occupying the majority of the central visual axis, and a severe ripple effect created by melted concentric rings 28,29 . The largest defect created in this study in either IOL type at highest energy did not exceed 0.2 mm.…”

Section: Discussionmentioning

confidence: 65%

“…The largest defect created in this study in either IOL type at highest energy did not exceed 0.2 mm. Moderate damage (less than 0.5 mm) to the lens most commonly leads to mild glare or decreased visual acuity that does not require surgery to remove the IOL 29 . In our canine patients, such subtle visual deficits would be difficult to evaluate and may not be of great clinical relevance.…”

Section: Discussionmentioning

confidence: 89%

“…Moderate damage (less than 0.5 mm) to the lens most commonly leads to mild glare or decreased visual acuity that does not require surgery to remove the IOL. 29 In our canine patients, such subtle visual deficits would be difficult to evaluate and may not be of great clinical relevance. Clinically significant canine PCO, resulting in severely compromised vision, would probably have reached an advanced stage characterized by marked thickening and wrinkling of the lens capsule.…”

Section: Discussionmentioning

confidence: 90%

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Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in normal dog eyes

Beale

Salmon

Michau

et al. 2006

Veterinary Ophthalmology

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Both posterior lens capsules and IOLs were disrupted in an energy-dependent manner with minimal difference in number of capsulotomy sites or damage to the IOL between acrylic and PMMA IOLs. A therapeutic margin between capsulotomy threshold (2.6-2.7 mJ) and IOL damage threshold (4.9-5.7 mJ) was determined to reliably achieve capsulotomies with minimal IOL damage for both acrylic and PMMA IOLs in normal canine cadaver eyes.

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Photodisruption of a thin membrane near a solid boundary: an in vitro study of laser capsulotomy

et al. 2016

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A Nd:YAG laser photodisruption is a well-established tool for intraocular surgery, such as treatment of posterior capsule opacification that affects the visual function. During the intraocular procedure, called laser capsulotomy, the excitation pulse is focused several times just behind the posterior capsule and intraocular lens to create the central opening in the opacified capsule. We built an in-vitro experiment to (i) clarify the influence of the distance between the intraocular lens and the posterior capsule on the total-pulse energy required for the capsulotomy; and to (ii) investigate the main mechanisms responsible for the posterior-capsule opening. In our in-vitro model different distances between the solid boundary (imitating an intraocular lens) and the membrane (imitating the posterior capsule) simulate different types of posterior-capsule opacification. Our results show that procedure efficiency decreases by decreasing distance between the lens and the capsule. We also explain that for smaller distances between the pulse focus and the membrane, plasma and shock wave are responsible for the capsule disruption. Here, a risk for collateral damage significantly increases. On contrary, the membrane and the bubble jet disrupt the membrane, when pulse focus is moved away and the risk for intraocular-lens damage decreases. However, the membrane disruption is not very effective, if it is placed near the solid boundary that inhibits the membrane jet.

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Ripple-like intraocular lens damage from a neodymium:YAG laser

Cited by 7 publications

References 10 publications

A Polymeric Drug Depot Based on 7‐(2′‐Methacryloyloxyethoxy)‐4‐methylcoumarin Copolymers for Photoinduced Release of 5‐Fluorouracil Designed for the Treatment of Secondary Cataracts

A Polymeric Drug Depot Based on 7‐(2′‐Methacryloyloxyethoxy)‐4‐methylcoumarin Copolymers for Photoinduced Release of 5‐Fluorouracil Designed for the Treatment of Secondary Cataracts

Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in normal dog eyes

Photodisruption of a thin membrane near a solid boundary: an in vitro study of laser capsulotomy

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