Regional inequality has attracted considerable interest among academics and policy makers. However, few studies have focused on regional inequality in comprehensive development. This study quantitatively estimated the regional inequalities and imbalances in China at multiple scales using gross domestic product (GDP), population, and the inter‐calibrated Defense Meteorological Satellite Program’s Operational Line‐Scan System (DMSP/OLS) nighttime stable light (NSL) data for 1992–2013. The results are as follows. First, the GDP‐derived inequalities exhibited an inverted U‐shaped pattern, while the NSL‐derived continued to decline. Second, for both GDP and NSL data, the inequality within the western region contributed most to the within‐region inequalities, while the eastern region contributed least. Third, the highest inter‐provincial inequality was observed in the developed area, while disparity within the underdeveloped area was the lowest. Finally, at the provincial level, the imbalances in comprehensive development generally decreased from 1992 to 2013. Moreover, a correlation analysis between the GDP‐ and NSL‐derived inequalities showed that there were some similarities in inequalities during 1992–2013, especially in the eastern region. These findings highlight that the regional inequalities in economic development and comprehensive development exhibit different tendencies, and hence it is crucial for both scholars and government to focus on this issue.