Rising rates of colorectal cancer in younger adults

Potter, John D.

doi:10.1136/bmj.l4280

Cited by 16 publications

(9 citation statements)

References 19 publications

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“…The reasons underlying the marked increase in incidence in those aged under 50 years are not clear, but may relate to lifestyle factors, particularly around diet, body weight and physical activity, all of which are associated with increased risk of CRC. 20 Rising rates of obesity in younger life (which are indicators of diet and physical activity) are of particular interest, because excess adiposity is now experienced by more people at earlier life stages and a recent study has demonstrated a relationship between body mass index in childhood and risk of adult CRC. 21 We cannot necessarily screen our way out of this problem.…”

Section: Open Accessmentioning

confidence: 99%

Variation in changes in the incidence of colorectal cancer by age and association with screening uptake: an observational study

et al. 2020

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ObjectivesIn developed countries, the incidence of colorectal cancer (CRC) has declined in the over 50 years age group but increased in younger people. We studied CRC incidence by age and the influence of screening uptake.DesignAge-standardised and sex-standardised incidences for CRC from 1997 to 2017 were obtained from the Scottish Cancer Registry (SCR). In addition, linkage between the Scottish Bowel Screening Database and the SCR allowed investigation of any association between screening participation and CRC incidence.SettingScotland and the Scottish Bowel Screening Programme, in which guaiac faecal occult blood test screening was piloted from March 2000 and fully rolled by December 2009.ParticipantsFrom the introduction of screening in 2000 through to 2017, 2 395 172 were invited to participate, of whom 1 487 999 participated at least once.Main outcome measuresIncidence of CRC.ResultsIn the screening age range (50–74 years), CRC incidence peaked at 156.5 cases per 100 000 in 2010 after full roll-out of screening across Scotland but fell to 123.9 per 100 000 in 2017. However, under 50 years, there was a rise from 5.3 cases per 100 000 in 2000 to 6.8 per 100 000 in 2017. When CRC incidence was examined in those who had been offered screening, incidence fell in the participant group more than in the non-participant group after roll-out of screening was complete. Analysis of cumulative incidence demonstrated that CRC incidence in the participant group remained consistently below that of the non-participant from around 7 years of follow-up.ConclusionsThe incidence of CRC in Scotland has declined in the over 50 years age group but increased in younger people. It is likely that population screening has contributed to the reduction in CRC incidence in the over 50 years age group.

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Section: Open Accessmentioning

confidence: 99%

Variation in changes in the incidence of colorectal cancer by age and association with screening uptake: an observational study

et al. 2020

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“…According to the 2020 Global Cancer Statistics Report Interpretation [1], colorectal cancer (CRC) is expected to be the 3rd in the global incidence spectrum and the 2nd in the cause of death spectrum among new cancers worldwide in 2020, and the rate of death continues to increase. Potter John D (2020) [2] found that the standardized incidence and mortality rates of CRC are higher in men than in women, and the number of colorectal cancers has increased among young people. And recurrence and metastasis of colorectal cancer after surgery are the main causes of death of patients.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Pathogenesis of Pulmonary Metastasis of Colorectal Cancer based on “the Lung and the Large Intestine are in Close Proximity”

2023

JCMP

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Lung is the second major metastatic site of colorectal cancer, and it is of great significance to discuss the pathogenesis of lung metastasis of colorectal cancer for its prevention and prognosis. In this paper, we explain the TCM pathogenesis of lung metastasis of colorectal cancer based on the theory of "lung and large intestine are in phase with each other" and the research of TCM, and believe that qi elevation is the driving force of transmission, fluid metabolism is the pathological basis, meridians and channels are the basic pathways, and the theory of yin and yang five elements is the philosophical basis. The aim is to enrich its theoretical basis and then guide clinical treatment.Keywords: The lungs and the large intestine are in close proximity to each other, Lung metastasis from colorectal cancer, TCM pathogenesis.

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“…In the Netherlands, colorectal cancer (CRC) is one of the most commonly diagnosed cancers with around 11,700 new cases in 2020 [1]. Increased incidence of CRC among young adults (50 years of age and younger) has recently been reported [2,3]. In women, the lifetime risk of developing CRC (4.1%) is slightly lower than for men (4.4%) [4].…”

Section: Introductionmentioning

confidence: 99%

Ovarian metastases in young women with colorectal cancer: a retrospective multicenter cohort study

Meer

Bakkers

Wegdam

et al. 2022

Int J Colorectal Dis

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Rising rates of colorectal cancer in younger adults

Abstract: Worsening diet, obesity, and lack of exercise are probable major contributors

Cited by 16 publications

References 19 publications

Variation in changes in the incidence of colorectal cancer by age and association with screening uptake: an observational study

Variation in changes in the incidence of colorectal cancer by age and association with screening uptake: an observational study

Exploring the Pathogenesis of Pulmonary Metastasis of Colorectal Cancer based on “the Lung and the Large Intestine are in Close Proximity”

Ovarian metastases in young women with colorectal cancer: a retrospective multicenter cohort study

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