Rising risk of type 2 diabetes among inhabitants of Jamnagar, Gujarat: A cross-sectional survey

Sharma, Rohit; Prajapati, PK

doi:10.4103/0974-8520.169014

Cited by 14 publications

(9 citation statements)

References 14 publications

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“…It is closely related to unhealthy lifestyles, overweight and physical inactivity. Unhealthy diet, lack of exercise, and other unhealthy lifestyle habits are associated with the development of diabetes [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Gut microbiome analysis of type 2 diabetic patients from the Chinese minority ethnic groups the Uygurs and Kazaks

et al. 2017

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The gut microbiome may have an important influence on the development of diabetes mellitus type 2 (DM2). To better understand the DM2 pandemic in ethnic minority groups in China, we investigated and compared the composition and richness of the gut microbiota of healthy, normal glucose tolerant (NGT) individuals and DM2 patients from two ethnic minority groups in Xinjiang, northwest China, the Uygurs and Kazaks. The conserved V6 region of the 16S rRNA gene was amplified by PCR from the isolated DNA. The amplified DNA was sequenced and analyzed. An average of 4047 high quality reads of unique tag sequences were obtained from the 40 Uygurs and Kazaks. The 3 most dominant bacterial families among all participants, both healthy and DM2 patients, were the Ruminococcaceae, Lachnospiraceae, and Enterobacteriaceae. Significant differences in intestinal microbiota were found between the NGT individuals and DM2 patients, as well as between the two ethnic groups. Our findings shed new light on the gut microbiome in relation to DM2. The differentiated microbiota data may be used for potential biomarkers for DM2 diagnosis and prevention.

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Section: Introductionmentioning

confidence: 99%

Gut microbiome analysis of type 2 diabetic patients from the Chinese minority ethnic groups the Uygurs and Kazaks

et al. 2017

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“…Type II diabetes (TIID) represents about 90% of all diabetes cases worldwide. It is associated with an unhealthy lifestyle and diet, obesity, lack of exercise and physical activity, in addition to other poor dietary habits [9]. The third class is known as MODY (Maturity onset diabetes of the young).…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the gut microbiome in Egyptian patients with Type I and Type II diabetes

et al. 2020

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Introduction Diabetes remains a growing public health concern in Egypt, as prevalence of Type II diabetes (TIID) has nearly tripled there in the last two decades. Egypt was ranked ninth worldwide in number of diabetes cases, with prevalence of 15.56% among adults. Recent studies have proposed that disturbance of gut microbiota could influence TIID development and indicated associations between a reduced diversity in microbiomes and Type I diabetes (TID). In the present study, we investigated the composition and abundance of the bacterial microbiome in disease state (TID and TIID) of Egyptian patients. Our goal in this study was to characterize features of the gut microbiota and possible differences associated with TID and TIID in this population. Methods DNA was extracted from fecal samples taken from 22 TID and 18 TIID outpatients of Al-Hussein hospital, Cairo, Egypt. 16S rRNA amplicon sequencing was used to characterize the bacterial taxa and these reads were processed using the software mothur with analysis utilizing packages vegan, phyloseq and metagenomSeq in R. Results and conclusions Our results highlighted a significant increase in abundance of Gram negative, potentially opportunistic pathogenic taxa (Pseudomonas, Prevotella) in all diabetic groups, compared to the control. Lipopolysccharide (LPS), a component of the gram-negative bacterial wall, can activate local immune response and may result in low-grade systemic inflammation contributing to insulin resistance. The gram-positive Gemella, which is associated with increased risk to diabetes, also had a significant increase in abundance in all diabetic groups, compared to the control. In contrast, the commensal bacterial taxa Turicibacter, Terrisporobacter and Clostridium were found to be more abundant in the control group than

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“…Diabetes mellitus is a worldwide menace and exponentially growing metabolic disease in India, 52 affecting the lipid and carbohydrate metabolism and affecting the person physically as well as mentally. 53,54 The knowledge on the heterogeneity of this order is advanced, the need for more appropriate therapy increases.…”

Section: Anti-diabetic Claims Of Herbsmentioning

confidence: 99%

Nutraceuticals in the management of diabetes mellitus

Nimesh¹,

Ashwlayan²

2018

PPIJ

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Recent years witnessed an upsurge in the use of nutraceuticals, nutritionals and naturals in therapeutics at global level. Conventional treatment options available as synthetic drugs does not meet properly the therapeutic needs for treating diabetes and the herbal drugs provide a better therapeutic hope with lesser side effects. Nutraceuticals are non-specific biological therapies including botanicals, vitamins, antioxidants, minerals, amino acids and fatty acids, which are used to promote wellness, prevent malignant processes and control symptoms. Nutraceutical agents have multidimensional therapeutic benefits and have been claimed to have effective disease preventing, curative and health promotive virtues. Several nutraceuticals used in clinical practice have been shown to target the pathogenesis of diabetes mellitus, metabolic syndrome and their complications and to favourably modulate a number of biochemical and clinical endpoints. Hypoglycaemic drugs are widely used in several traditional systems of medicine to prevent diabetes mellitus. This review attempts to display and remark some of the most popular nutraceuticals being use as anti-diabetic.

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Rising risk of type 2 diabetes among inhabitants of Jamnagar, Gujarat: A cross-sectional survey

Cited by 14 publications

References 14 publications

Gut microbiome analysis of type 2 diabetic patients from the Chinese minority ethnic groups the Uygurs and Kazaks

Gut microbiome analysis of type 2 diabetic patients from the Chinese minority ethnic groups the Uygurs and Kazaks

A comparative study of the gut microbiome in Egyptian patients with Type I and Type II diabetes

Nutraceuticals in the management of diabetes mellitus

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