Risk and prognosis of second corpus uteri cancer after radiation therapy for pelvic cancer: A population-based analysis

Yu, Guanhua; Wei, Ran; Li, Shuofeng; Wang, Yongjiao; Liu, Hengchang; Chen, Tianli; Guan, Xu; Wang, Xishan; Jiang, Zheng

doi:10.3389/fonc.2022.957608

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…The high incidence of endometrial cancer and mortality among cancer survivors may be attributable to genetic mutations and systemic treatments, including chemotherapy and radiotherapy for prior cancers. 24–26 Patients with FPC who have received systemic treatments such as radiotherapy and chemotherapy may result in SPECs that are less sensitive and tolerant to radiotherapy and chemotherapy. As shown in our study, surgical treatment for endometrial cancer was associated with a reduced risk of ECSM and non-ECSM, but radiotherapy and chemotherapy were associated with an increased risk of ECSM.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors for Secondary Endometrial Cancer-Related Death: A SEER-Based Study

Miao,

Feng,

Ding

et al. 2024

IJWH

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Purpose The aim of this study was to analyze the survival of patients with endometrial cancer diagnosed after a prior cancer and identify risk factors of endometrial cancer death in this population. Methods Totally 1371 women diagnosed with second primary endometrial cancer (SPEC) between 2004 and 2015 were identified using the SEER database. Clinicopathological characteristics were collected, and Fine and Gray regression model was employed to assess the impact of treatment for the first primary cancer (FPC) and SPEC on the mortality of endometrial cancer patients. After propensity score matching (PSM), patients diagnosed with single primary endometrial cancer and SPEC between 2004 and 2015 were included as the second cohort. Kaplan-Meier and Cox survival risk models were used to assess the influence of previous cancer history on survival. Results Patients previously diagnosed as lung cancer exhibited the lowest overall survival (OS). A diagnostic interval of ≥3 years was significantly associated with higher mortality from SPEC compared with that <3 years. Surgical treatment for SPEC was linked to a reduced risk of endometrial cancer-specific mortality (ECSM) and non-ECSM. Conversely, radiotherapy and chemotherapy were associated with an increased risk of ECSM. The 1-, 3-, and 5-year OS rates of patients with SPEC were significantly lower than those with single primary endometrial cancer whether before or after PSM. Univariate and multivariate analyses further demonstrated that endometrial cancer, either as FPC or SPEC, was independently associated with an increased risk for endometrial cancer-specific survival (ECSS) and OS. Conclusion Chemotherapy and radiotherapy for SPEC can elevate the risk of ECSM. Whether as FPC or SPEC, endometrial cancer is demonstrated to be a significant independent risk factor for ECSS and OS.

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Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors for Secondary Endometrial Cancer-Related Death: A SEER-Based Study

Miao,

Feng,

Ding

et al. 2024

IJWH

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“…Current studies have shown that in the abdominopelvic site, radiotherapy for in situ cancers leads to increased secondary cancers, [9][10][11] and even radiotherapy affects the risk of cardiac death in patients with tumors, 12 but there are no relevant studies in the chest. During RT for cancer of one of the thoracic organs, the lung is usually within the field of irradiation.…”

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confidence: 99%

Risk and prognosis of secondary lung cancer after radiation therapy for thoracic malignancies

Chen,

Liu,

et al. 2024

Clinical Respiratory J

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ObjectiveRadiation therapy (RT) may increase the risk of second cancer. This study aimed to determine the association between exposure to radiotherapy for the treatment of thoracic cancer (TC) and subsequent secondary lung cancer (SLC).Materials and MethodsThe Surveillance, Epidemiology, and End Results (SEER) database (from 1975 to 2015) was queried for TC. Univariate Cox regression analyses and multiple primary standardized incidence ratios (SIRs) were used to assess the risk of SLC. Subgroup analyses of patients stratified by latency time since TC diagnosis, age at TC diagnosis, and calendar year of TC diagnosis stage were also performed. Overall survival and SLC‐related death were compared among the RT and no radiation therapy (NRT) groups by using Kaplan–Meier analysis and competitive risk analysis.ResultsIn a total of 329 129 observations, 147 847 of whom had been treated with RT. And 6799 patients developed SLC. Receiving radiotherapy was related to a higher risk of developing SLC for TC patients (adjusted HR, 1.25; 95% CI, 1.19–1.32; P < 0.001). The cumulative incidence of developing SLC in TC patients with RT (3.8%) was higher than the cumulative incidence (2.9%) in TC patients with NRT(P). The incidence risk of SLC in TC patients who received radiotherapy was significantly higher than the US general population (SIR, 1.19; 95% CI, 1.14–1.23; P < 0.050).ConclusionsRadiotherapy for TC was associated with higher risks of developing SLC compared with patients unexposed to radiotherapy.

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Risk prediction of second primary malignancies after gynecological malignant neoplasms resection with and without radiation therapy: a population-based surveillance, epidemiology, and end results (SEER) analysis

Wang

Zhang

Xiang

et al. 2023

J Cancer Res Clin Oncol

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Purpose The association between post-resection radiotherapy for primary gynecological malignant neoplasms (GMNs) and the development of secondary primary malignancies (SPMs) remains a subject of debate. This study represents the first population-based analysis employing a multivariate competitive risk model to assess risk factors for this relationship and to develop a comprehensive competing-risk nomogram for quantitatively predicting SPM probabilities. Materials and methods In our study, data on patients with primary GMNs were retrospectively collected from the Epidemiology, Surveillance and End Results (SEER) database from 1973 to 2015. The incidence of secondary malignant tumors diagnosed at least six months after GMN diagnosis was compared to determine potential risk factors for SPMs in GMN patients using the Fine and Gray proportional sub-distribution hazard model. A competing-risk nomogram was constructed to quantify SPM probabilities. Results A total of 109,537 patients with GMNs were included in the study, with 76,675 and 32,862 GMN patients in the training and verification sets, respectively. The competing-risk model analysis identified age, primary tumor location, tumor grade, disease stage, chemotherapy, and radiation as risk factors for SPMs in GMN patients. Calibration curves and ROC curves in both training and verification cohorts demonstrated the predictive accuracy of the established nomogram, which exhibited a good ability to predict SPM occurrence. Conclusions This study presents the nomogram developed for quantitatively predicting SPM probabilities in GMN patients for the first time. The constructed nomogram can assist clinicians in designing personalized treatment strategies and facilitate clinical decision-making processes.

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Risk and prognosis of second corpus uteri cancer after radiation therapy for pelvic cancer: A population-based analysis

Cited by 4 publications

References 30 publications

Analysis of Risk Factors for Secondary Endometrial Cancer-Related Death: A SEER-Based Study

Analysis of Risk Factors for Secondary Endometrial Cancer-Related Death: A SEER-Based Study

Risk and prognosis of secondary lung cancer after radiation therapy for thoracic malignancies

Risk prediction of second primary malignancies after gynecological malignant neoplasms resection with and without radiation therapy: a population-based surveillance, epidemiology, and end results (SEER) analysis

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