Risk assessment of airborne fine particles and nanoparticles

Myojo, Toshihiko; Ogami, Akira; Oyabu, Takako; Morimoto, Yasuo; Hirohashi, Masami; Murakami, Masahirô; Nishi, Kenichiro; Kadoya, Chikara; Tanaka, Isamu

doi:10.1016/j.apt.2010.05.004

Cited by 15 publications

(5 citation statements)

References 15 publications

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“…The particle size distribution is an essential parameter that explains tendency of the deposition of nanomaterials in lung. A previous study reported by Ryman-Rasmussen et al [11] , Myojo et al [12] and Geraets et al [13] reveals the size dependent deposition of particles in the respiratory tract. The rats were exposed to MWCNTs for of 4 h continuously at an average actual aerosol concentration of 5 mg/m 3 , while the control rats were exposed to clean air.…”

Section: Resultsmentioning

confidence: 81%

One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats

et al. 2015

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We have investigated the time-dependent effect of multi-walled carbon nanotubes (MWCNTs) in rats upon single inhalation exposure followed by intermittent sacrifice. The effects were monitored by analyzing the bronchoalveolar lavage fluid (BALF) and histopathological analysis. Cell count, neutrophils, lymphocytes, lactate dehydrogenase, alkaline phosphatase, protein and cytokines (tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)) were significantly increased, while cell viability and alveolar macrophage count significantly decreased in the BALF of MWCNT-treated rats on day 1, day 7 and day 14 post-exposure, when compared to control rats. Histopathological analysis revealed inflammation, fibrosis and granuloma in the lungs of MWCNTs-treated rats on day 7 and day 14 post-exposure. We interpret that MWCNT induces inflammation, fibrosis and granuloma characterized by progressive elevation of TNF-α and IL-4. Histopathological studies further support our view and reveal the distribution of MWCNT in lungs and tracheobronchial lymph nodes (TBLN). We conclude that MWCNT-induced pulmonary toxicity is considerable even on single exposure.

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Section: Resultsmentioning

confidence: 81%

One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats

et al. 2015

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“…Myojo et al [48] indicated that physicochemical characterization study could evaluate particle size distribution and their solubility. In vitro study on cultured cells, intratracheal instillation study on animals, and short and long term exposure study on animals, can estimate hazardous effect of particles by multifaceted and cross-comparative examinations of each result.…”

Section: Discussionmentioning

confidence: 99%

Risk management strategy to increase the safety of workers in the nanomaterials industry

Ling

Lin

Liu

et al. 2012

Journal of Hazardous Materials

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“…combustion and mechanical wear) have received a lot of attention during recent advances in nano-, energy-environmental, biomedical, and information technologies because health effects (e.g. cardiovascular diseases and cancer) of inhaled fine particles are well-known (Nazarenko et al 2012;Myojo et al 2010). Pulmonary deposition of inhalable particles provides a direct route to the blood circulation through the single-cell layered alveolar-capillary barrier of the lungs (Oberd€ orster and Utell 2002; Fr€ ohlich and Salar-Behzadi 2014).…”

Section: Introductionmentioning

confidence: 99%

Direct fluorescent labeling for efficient biological assessment of inhalable particles

et al. 2017

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Labeling of aerosol particles with a radioactive, magnetic, or optical tracer has been employed to confirm particle localization in cell compartments, which has provided useful evidence for correlating toxic effects of inhaled particles. However, labeling requires several physicochemical steps to identify functionalities of the inner or outer surfaces of particles, and moreover, these steps can cause changes in size, surface charge, and bioactivity of the particles, resulting in misinterpretations regarding their toxic effects. This study addresses this challenging issue with a goal of introducing an efficient strategy for constantly supplying labeled aerosol particles in a single-pass configuration without any pre-or post-physicochemical batch treatments of aerosol particles. Carbon black (CB, simulating combustion-generated soot) or calcium carbonate (CC, simulating brake-wear fragments) particles were constantly produced via spark ablation or bubble bursting, respectively. These minute particles were incorporated with fluorescein isothiocyanate-poly(ethylene glycol) 2-aminoethyl ether acetic acid solution at the orifice of a collison atomizer to fabricate hybrid droplets. The droplets successively entered a diffusion dryer containing 254-nm UV irradiation; therefore, the droplets were dynamically stiffened by UV to form fluorescent probes on particles during solvent extraction in the dryer. Particle size distributions, morphologies, and surface charges before and after labeling were measured to confirm fluorescence labeling without significant changes in the properties. In vitro assays, including confocal imaging, were conducted to confirm the feasibility of the labeling approach without inducing significant differences in bioactivity compared with untreated CB or CC particles. ARTICLE HISTORY

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Risk assessment of airborne fine particles and nanoparticles

Cited by 15 publications

References 15 publications

One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats

One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats

Risk management strategy to increase the safety of workers in the nanomaterials industry

Direct fluorescent labeling for efficient biological assessment of inhalable particles

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